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Aging, Biology of
Gordon Research Conference

Integrative Biology of Aging: New Insights from Molecules to Systems

Dates

July 9-14, 2017

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland Site Information

Organizers

Chairs:
Adam Antebi & Shin-Ichiro Imai

Vice Chairs:
Thomas Rando & Marcia C. Haigis

Application Deadline

Applications for this meeting must be submitted by June 11, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Gordon Research Conference (GRC) on the Biology of Aging will be held at the Les Diablerets Conference Center (Les Diablerets, Switzerland) on July 9-14, 2017, and the Gordon Research Seminar (GRS), which will be held at the same location on July 8-9, immediately prior to the GRC. The program has been developed around the theme of "Integrative Biology of Aging: New Insights from Molecules to Systems". Recent studies from diverse model organisms, such as worms, flies, and mice, have demonstrated that systemic interplay between multiple tissues and organs regulates aging and longevity. Additionally, subcellular systems such as organelles and stress pathways can often communicate intra- and intercellularly. To dissect such complex systemic regulation of aging and longevity, significant progress has been made in identifying control networks and basic architectures, but how communication is achieved at different levels of organization and assembled into larger architectures is only beginning to be explored. The dysfunction of critical components in these control networks contributes to the induction of the cellular and molecular hallmarks of aging, including mitochondrial dysfunction, epigenetic alterations, chronic inflammation, circadian rhythm dysfunction, genomic instability, loss of proteostasis, and others, and underlies diminished healthspan and lifespan. In the 2017 GRC, our major objective is to capture this new wave of the "integrative biology of aging", and further stimulate our thoughts and efforts to translate our knowledge into the development of effective interventions to achieve "productive aging", making the later years of our lives as healthy and productive as possible. The major objective of the GRS is to explore these themes in a supportive setting that particularly focuses on the needs of graduate students and postdoctoral trainees, and prepare them for a full and productive participation in the GRC to follow.

Related Meeting

This GRC will be held in conjunction with the "Aging, Biology of" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Perspective — Integrative Biology of Aging
Discussion Leader: Gerald Shadel (Yale School of Medicine, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:35 pmMichael Hall (Biozentrum, University of Basel, Switzerland)
"mTOR Signaling in Growth and Metabolism"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmShort Talk Selected from Poster Abstracts
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmLate-Breaking Topic
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFragility in Aging: Mitochondria and ER
Discussion Leader: Coleen Murphy (Princeton University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amGerald Shadel (Yale School of Medicine, USA)
"Mitochondrial Stress Signaling in Aging, Disease and Immunity"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amWilliam Mair (Harvard T. H. Chan School of Public Health, USA)
"Contextual Roles for Mitochondrial Network States in Longevity"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:05 amMeng Wang (Baylor College of Medicine, USA)
"Microbiome and Gut Mitochondria in Longevity Control in C. elegans"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amShort Talk Selected from Poster Abstracts
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:30 pmDiscussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Coleen Murphy (Princeton University, USA), Anne Bertolotti (MRC Laboratory of Molecular Biology, United Kingdom) and Akiko Satoh (National Center for Geriatrics and Gerontology, Japan)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmFragility in Aging: Epigenetics
Discussion Leader: Manuel Serrano (Centro Nacional de Investigaciones Oncológicas, Spain)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmAndrew Yoo (Washington University School of Medicine, USA)
"Modeling Aging of Human Neurons via Neuronal Reprogramming of Somatic Cells"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmMasashi Narita (University of Cambridge, United Kingdom)
"Cell-Cell Communication in Senescence"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmSteve Horvath (University of California, Los Angeles, USA)
"Anti-Aging Interventions Versus Epigenetic Aging"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPerturbation: Inflammation, Metabolism, and Aging
Discussion Leader: Vera Gorbunova (University of Rochester, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amColeen Murphy (Princeton University, USA)
"Integrative Cross-Species Network-Based Analysis Reveals Roles for BCAA and Cholinergic Signaling in Parkinson's Disease"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amDario Valenzano (Max Planck Institute for Biology of Aging, Germany)
"Life Span Modulation by Gut Microbiota Transfer in the Naturally Short-Lived African Turquoise Killifish"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:05 amSivan Henis-Korenblit (Bar-Ilan University, Israel)
"A Novel siRNA Signal Promotes Longevity and Heat Shock Response in C. elegans"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amShort Talk Selected from Poster Abstracts
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPerturbation: Biological Rhythm and Aging
Discussion Leader: Steve Horvath (University of California, Los Angeles, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmJadwiga Giebultowicz (Oregon State University, USA)
"Aging Around the Clock"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmAkiko Satoh (National Center for Geriatrics and Gerontology, Japan)
"Hypothalamic Sirtuins and mTOR Signaling Pathway: A Key Regulator of Sleep, Aging and Longevity"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:35 pmShort Talk Selected from Poster Abstracts
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmLate-Breaking Topic
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRobustness: Stress and Damage Responses
Discussion Leader: Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amEiji Hara (Research Institute for Microbial Diseases, Osaka University, Japan)
"The Roles and Mechanisms of Cellular Senescence in Aging-Associated Cancer"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amVera Gorbunova (University of Rochester, USA)
"SIRT6 Mediates Coevolution of DNA Repair and Longevity in Rodents"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:05 amManuel Serrano (Centro Nacional de Investigaciones Oncológicas, Spain)
"Links Between Cancer and Aging"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amShort Talk Selected from Poster Abstracts
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRobustness: Proteostasis and Autophagy
Discussion Leader: Tony Wyss-Coray (Stanford University School of Medicine, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmMalene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Autophagy and Aging: Lessons from Long-Lived Animals"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmAnne Bertolotti (MRC Laboratory of Molecular Biology, United Kingdom)
"Proteostasis and Age-Associated Neurodegeneration"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:35 pmShort Talk Selected from Poster Abstracts
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmLate-Breaking Topic
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmSystemic Regulation of Aging and Longevity
Discussion Leader: Valter Longo (University of Southern California, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amTony Wyss-Coray (Stanford University School of Medicine, USA)
"Systemic Regulation of Brain Aging and Neurodegeneration"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amFabio Demontis (St. Jude Children's Research Hospital, USA)
"Systemic Signaling via Myokines for Aging and Longevity Control"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:05 amPura Munoz-Canoves (ICREA / Universitat Pompeu Fabra, Spain)
"Understanding Muscle Stem Cell Regenerative Decline with Aging"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amEline Slagboom (Leiden University Medical Center, The Netherlands)
"Longevity, Healthy Ageing and Disease. The Metabolome as a Biomarker"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmLate-Breaking Topic
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmInterventions for Productive Aging
Discussion Leader: Anne Bertolotti (MRC Laboratory of Molecular Biology, United Kingdom)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmValter Longo (University of Southern California, USA)
"Fasting Mimicking Diets and Multi-System Regeneration"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmCarles Canto (Nestlé Institute of Health Sciences, Switzerland)
"Nicotinamide Riboside Metabolism: Roles in Health and Disease"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmDena Dubal (UCSF Medical Center, USA)
"Klotho and Brain Resilience"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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