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Biology of Aging
Gordon Research Conference

Integrative Biology of Aging: New Insights from Molecules to Systems

Dates

July 9-14, 2017

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland

Organizers

Chairs:
Adam Antebi & Shin-Ichiro Imai

Vice Chairs:
Thomas Rando & Marcia C. Haigis

Meeting Description

The 2017 Gordon Research Conference (GRC) on the Biology of Aging will be held at the Les Diablerets Conference Center (Les Diablerets, Switzerland) on July 9-14, 2017, and the Gordon Research Seminar (GRS), which will be held at the same location on July 8-9, immediately prior to the GRC. The program has been developed around the theme of "Integrative Biology of Aging: New Insights from Molecules to Systems". Recent studies from diverse model organisms, such as worms, flies, and mice, have demonstrated that systemic interplay between multiple tissues and organs regulates aging and longevity. Additionally, subcellular systems such as organelles and stress pathways can often communicate intra- and intercellularly. To dissect such complex systemic regulation of aging and longevity, significant progress has been made in identifying control networks and basic architectures, but how communication is achieved at different levels of organization and assembled into larger architectures is only beginning to be explored. The dysfunction of critical components in these control networks contributes to the induction of the cellular and molecular hallmarks of aging, including mitochondrial dysfunction, epigenetic alterations, chronic inflammation, circadian rhythm dysfunction, genomic instability, loss of proteostasis, and others, and underlies diminished healthspan and lifespan. In the 2017 GRC, our major objective is to capture this new wave of the "integrative biology of aging", and further stimulate our thoughts and efforts to translate our knowledge into the development of effective interventions to achieve "productive aging", making the later years of our lives as healthy and productive as possible. The major objective of the GRS is to explore these themes in a supportive setting that particularly focuses on the needs of graduate students and postdoctoral trainees, and prepare them for a full and productive participation in the GRC to follow.

Related Meeting

This GRC was held in conjunction with the "Biology of Aging" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Perspective — Integrative Biology of Aging
Discussion Leader: Gerald Shadel (Yale School of Medicine, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:35 pmMichael Hall (Biozentrum, University of Basel, Switzerland)
"mTOR Signaling in Growth and Metabolism"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmSelected from Poster Abstracts: David Glass (Novartis Institutes for Biomedical Research, USA)
"Short-Term mTORC1 Inhibition Regulates Key Components of the Aging Gene Expression Signature"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Nalle Pentinmikko (University of Helsinki, Finland)
"Age-Induced Expression of Notum in the Stem Cell Niche Attenuates Regenerative Potential of Intestinal Epithelium"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFragility in Aging: Mitochondria and ER
Discussion Leader: Daniel Promislow (University of Washington, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amGerald Shadel (Yale School of Medicine, USA)
"Mitochondrial Stress Signaling in Aging, Disease and Immunity"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amWilliam Mair (Harvard T. H. Chan School of Public Health, USA)
"Contextual Roles for Mitochondrial Network States in Longevity"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:05 amMeng Wang (Baylor College of Medicine, USA)
"Microbiome and Gut Mitochondria in Longevity Control in C. elegans"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amSelected from Poster Abstracts: Anil Rana (University of California, Los Angeles, USA)
"Promoting Drp1-Mediated Mitochondrial Fission in Midlife Facilitates Mitophagy and Increases Healthy Lifespan"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Vanina Romanello (University of Padova, Italy)
"Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation and Epithelial Senescence"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmSelected from Poster Abstracts: Richard Miller (University of Michigan, USA)
"mTOR-Dependent Translation Control Switches in Slow-Aging Mutant Mice"
12:20 pm - 12:30 pmDiscussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Akiko Satoh (National Center for Geriatrics and Gerontology, Japan), Pura Munoz-Canoves (Spanish National Cardiovascular Research Centre (CNIC), Spain) and Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmFragility in Aging: Epigenetics
Discussion Leader: Pura Munoz-Canoves (Spanish National Cardiovascular Research Centre (CNIC), Spain)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmAndrew Yoo (Washington University School of Medicine, USA)
"Modeling Aging of Human Neurons via Neuronal Reprogramming of Somatic Cells"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmMasashi Narita (University of Cambridge, United Kingdom)
"Cell-Cell Communication in Senescence"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmSteve Horvath (University of California, Los Angeles, USA)
"Anti-Aging Interventions Versus Epigenetic Aging"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPerturbation: Inflammation, Metabolism, and Aging
Discussion Leader: Vera Gorbunova (University of Rochester, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amDaniel Promislow (University of Washington, USA)
"The Metabolome as a Bridge Between Genotype and Phenotype"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amDario Valenzano (Max Planck Institute for Biology of Aging, Germany)
"Life Span Modulation by Gut Microbiota Transfer in the Naturally Short-Lived African Turquoise Killifish"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:05 amSivan Henis-Korenblit (Bar-Ilan University, Israel)
"A Novel siRNA Signal Promotes Longevity and Heat Shock Response in C. elegans"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amSelected from Poster Abstracts: Jonathan Lin (Washington University School of Medicine in St. Louis, USA)
"Upregulation of MicroRNA-150 in Aged Macrophages Promotes Age-Related Macular Degeneration"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Isabel Beerman (National Institutes of Health, USA)
"Age-Associated Clonal Dominance of Myeloid-Biased HSC Is Underwritten by Unique Transcriptional and Epigenetic Alterations"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmSelected from Poster Abstracts: Varnesh Tiku (Max Planck Institute for Biology of Ageing, Germany)
"Small Nucleoli Are a Cellular Hallmark of Longevity"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPerturbation: Biological Rhythm and Aging
Discussion Leader: Steve Horvath (University of California, Los Angeles, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmJadwiga Giebultowicz (Oregon State University, USA)
"Aging Around the Clock"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmAkiko Satoh (National Center for Geriatrics and Gerontology, Japan)
"Hypothalamic Sirtuins and mTOR Signaling Pathway: A Key Regulator of Sleep, Aging and Longevity"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:35 pmSelected from Poster Abstracts: Hong Gil Nam (Institute for Basic Science / Daegu Gyeongbuk Institute of Science and Technology (DGIST), South Korea)
"Positive Feedback Between the Arabidopsis Aging Regulator ORE1 and Circadian Clock Components Promotes Robust Rhythmicity"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Matthew Ulgherait (Columbia University Medical Center, USA)
"Circadian Regulation of Aging and Mitochondrial Uncoupling"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRobustness: Stress and Damage Responses
Discussion Leader: Malene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amEiji Hara (Research Institute for Microbial Diseases, Osaka University, Japan)
"The Roles and Mechanisms of Cellular Senescence in Aging-Associated Cancer"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amVera Gorbunova (University of Rochester, USA)
"SIRT6 Mediates Coevolution of DNA Repair and Longevity in Rodents"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:05 amCynthia Kenyon (Calico Life Sciences LLC, USA)
"Cellular Quality Control in C. elegans"
11:05 am - 11:15 amDiscussion
11:15 am - 11:30 amSelected from Poster Abstracts: Darren Baker (Mayo Clinic, USA)
"Elucidating the In Vivo Impact of Senescent Cells to Age-Related Diseases"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Andrew Rallis (Institute of Biology Valrose, France)
"The Hh Signalling Pathway Modulates Lifespan Determination and Neuroprotection in Drosophila"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:20 pmSelected from Poster Abstracts: Marco De Cecco (Brown University, USA)
"Chromatin Rearrangements and Endogenous Retroelements De-Repression During Cellular Senescence"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRobustness: Proteostasis and Autophagy
Discussion Leader: Tony Wyss-Coray (Stanford University School of Medicine, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmMalene Hansen (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Autophagy and Aging: Lessons from Long-Lived Animals"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmAnne Bertolotti (MRC Laboratory of Molecular Biology, United Kingdom)
"Proteostasis and Age-Associated Neurodegeneration"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:35 pmSelected from Poster Abstracts: Martin Denzel (Max Planck Institute for Biology of Ageing, Germany)
"The Hexosamine Pathway Modulates Protein Quality Control in Mammals"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Nelson Hsieh (Case Western Reserve University, USA)
"A Conserved KLF-Autophagy Pathway Modulates Nematode Lifespan and Mammalian Age-Associated Vascular Dysfunction"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmSystemic Regulation of Aging and Longevity
Discussion Leader: Valter Longo (University of Southern California, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amTony Wyss-Coray (Stanford University School of Medicine, USA)
"Systemic Regulation of Brain Aging and Neurodegeneration"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amFabio Demontis (St. Jude Children's Research Hospital, USA)
"Regulators of Myofiber Size and Sarcopenia"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:05 amPura Munoz-Canoves (Spanish National Cardiovascular Research Centre (CNIC), Spain)
"Understanding Muscle Stem Cell Regenerative Decline with Aging"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amEline Slagboom (Leiden University Medical Center, The Netherlands)
"Longevity, Healthy Ageing and Disease. The Metabolome as a Biomarker"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: James Mitchell (Harvard University, USA)
"Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Kristin Gribble (Marine Biological Laboratory, USA)
"Offspring Aging Is Transgenerationally Determined by Maternal Age and Diet"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmInterventions for Productive Aging
Discussion Leader: Anne Bertolotti (MRC Laboratory of Molecular Biology, United Kingdom)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmValter Longo (University of Southern California, USA)
"Fasting Mimicking Diets and Multi-System Regeneration"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmCarles Canto (Nestlé Institute of Health Sciences, Switzerland)
"Nicotinamide Riboside Metabolism: Roles in Health and Disease"
7:10 pm - 7:20 pmDiscussion
7:20 pm - 7:45 pmDena Dubal (UCSF Medical Center, USA)
"Klotho and Brain Resilience"
7:45 pm - 7:55 pmDiscussion
7:55 pm - 8:00 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible, in part by the National Institute On Aging of the National Institutes of Health under Award Number 1R13 AG056105 - 01. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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