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Thiol-Based Redox Regulation and Signaling
Gordon Research Conference

Thiols in Biology and Medicine: Innovations Driving Disease Prevention, Therapeutics and Quality of Life

Dates

August 7-12, 2016

Location

Stoweflake Conference Center
Stowe, VT

Organizers

Chair:
Cristina M. Furdui

Vice Chair:
Tobias Dick

Meeting Description

Redox biology is an all-encompassing term that refers to the multitude of reduction and oxidation processes occurring in biological systems. This Gordon conference focuses specifically on the redox regulation of protein function by modification of cysteine and methionine residues and on the agents that modulate the redox state of these residues such as reactive oxygen, nitrogen, and sulfur species – ROS, RNS, and RSS, respectively. The overarching goal of this conference is to explore redox regulation in the scientific space connecting aging, cancer and environmental diseases, and to disseminate the latest developments in chemical, molecular, technological and computational tools to researchers working in these areas of interest. This interdisciplinary conference is in its 6th cycle after five very successful meetings in the U.S. (2006 and 2012), Italy (2008 and 2010), and Spain (2014) and provides an important venue for the free exchange of ideas among the chemists, biochemists, molecular and cell biologists, physiologists, and clinicians working on various aspects of redox biology and medicine. By bringing together investigators with varied expertise in basic and clinical research, the meeting is expected to stimulate collaborations and catalyze scientific progress as has been exemplified by the success of the previous meetings.

The GRC will be preceded by a Gordon Research Seminar (GRS) (August 6-7, 2016), which provides opportunities for graduate students and postdoctoral scientists to formally present research and engage in scientific discussions on this important focus area of research.

Related Meeting

This GRC was held in conjunction with the "Thiol-Based Redox Regulation and Signaling" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: A Sulfur-Centered World: From Primordial Chemistry to Human Biology
Discussion Leaders: Tobias Dick (German Cancer Research Center, Germany) and Vadim Gladyshev (Harvard Medical School, USA)
7:40 pm - 8:20 pmRuma Banerjee (University of Michigan, USA)
"Signaling Through Sulfide: Chemical Biology of Sulfide Homeostasis"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmMichel Toledano (French Alternative Energies and Atomic Energy Commission (CEA), France)
"The Control of Eukaryotic Protein Secretion by a Novel Pathway Regulating Glutathione Traffic in and out of the ER"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEmerging Chemical, Omics and Computational Tools for Redox Biologists
Discussion Leaders: Vsevolod Belousov (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia) and Leslie Poole (Wake Forest School of Medicine, USA)
9:00 am - 9:20 amDean Jones (Emory University, USA)
"Exposure Memory and the Redox Theory of Aging"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amHarry Ischiropoulos (University of Pennsylvania, USA)
"Potential Functional Roles for Redox Regulated Cysteine Residues"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMelissa Kemp (Georgia Institute of Technology, USA)
"Computational Strategies for Interrogating Thiol Regulated Systems"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amEranthie Weerapana (Boston College, USA)
"Chemical-Proteomic Strategies to Investigate Reactive Cysteines"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMilos Filipovic (IBGC - Institut de Biochimie et Genetique Cellulaires / CNRS, France)
"Thioredoxin Controls Intracellular Levels of Protein Persulfidation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmTroy Langford (Massachusetts Institute of Technology, USA)
"Using Kinetic Models and Engineered Proteins to Further Quantitative Understanding of Thiol-Based Redox Regulation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Melissa Kemp (Georgia Institute of Technology, USA) and Kate Carroll (The Scripps Research Institute, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEssential Function of H2S and Other S-Containing Biomolecules in Human Health and Biology
Discussion Leaders: Ming Xian (Washington State University, USA) and Rodney Levine (National Institutes of Health, USA)
7:30 pm - 7:50 pmAlban Longchamp (Harvard University, USA)
"Regulation of Endogenous H2S and Mechanisms of Action in Angiogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmEd Schmidt (Montana State University, USA)
"The Robustness of Mammalian Redox Homeostasis: NADPH-Dependent and -Independent Disulfide Reductase Systems"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmMichael Pluth (University of Oregon, USA)
"Synthetic H2S Donors with Defined Release Mechanisms and Tunable Release Rates"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmBruno Manta (Brigham and Women's Hospital / Harvard Medical School, USA)
"Reversible Methionine Oxidation by Mical/MsrB as a New Axis in Redox Regulation and Signaling"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmWeijun Qian (Pacific Northwest National Laboratory, USA)
"Stoichiometric Quantification of S-Glutathionylation and Total Thiol Oxidation and Potential Crosstalk with Protein Phosphorylation"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJen-Tsan Chi (Duke University, USA)
"Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmExploiting Redox Effects in Modern Therapeutics
Discussion Leaders: Kate Carroll (The Scripps Research Institute, USA) and Arne Holmgren (Karolinska Institutet, Sweden)
9:00 am - 9:20 amDavid Boothman (University of Texas Southwestern Medical School, USA)
"Exploiting NQO1 Bioactivatable Drugs for Tumor-Selective DNA Repair Inhibition"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amBrion Murray (Pfizer Oncology Research Unit, USA)
"Protein S-Glutathionylation: An Emerging Post-translational Modification that Impacts Cell Biology and the Disease State"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amDaret St. Clair (University of Kentucky, USA)
"A Redox Distinction Approach to Cancer Therapy"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMartin Bergo (Karolinska Institute, Sweden)
"On the Role of Antioxidants in Tumor Initiation and Progression"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amYvonne Janssen-Heininger (University of Vermont, USA)
"Targeting S-Glutathionylation Chemistry to Combat Tissue Fibrosis"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJade Mims (Wake Forest School of Medicine, USA)
"Integration of Redox-Regulated Signaling and Metabolism in Head and Neck Cancer"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRedox Regulation of Cellular Communication
Discussion Leaders: Thomas Michel (Brigham and Women's Hospital / Harvard Medical School, USA) and Sue Goo Rhee (Yonsei University College of Medicine, South Korea)
7:30 pm - 7:50 pmAgnieszka Chacinska (International Institute of Molecular and Cell Biology in Warsaw, Poland)
"Cellular Consequences of Mitochondrial Stress"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMichael Ristow (Energy Metabolism Laboratory, ETH Zurich, Switzerland)
"Mitochondria, Metabolism and Aging"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPatricia Zambryski (University of California, Berkeley, USA)
"Plant Cell-to-Cell Communication via Plasmodesmata: Regulation by Organelle Redox State"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmStefano Bestetti (Fondazione Centro San Raffaele, Italy)
"Regulation of H2O2 Transport in Tumor Growth and Progression"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmPrakash Palde (The Scripps Research Institute, USA)
"Thioredoxin Selectively Recognizes Oxidized Target Proteins via an Entropy-Driven Common Mechanism"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCase Studies in Redox Control of Cellular Processes
Discussion Leaders: Elena Hidalgo (Pompeu Fabra University, Spain) and Tobias Dansen (University Medical Center Utrecht, The Netherlands)
9:00 am - 9:20 amJose Antonio Barcena (University of Cordoba, Spain)
"Redox Control of Protein Thiols by Redoxins Under Nitric Oxide Signaling"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMyra Conway (University of the West of England, United Kingdom)
"Dysregulated Redox Metabolons and Their Implications in Alzheimer's Disease"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amAna Denicola (University of the Republic, Uruguay)
"Interplay Between Nitration and Overoxidation in Peroxiredoxins. Impact on H2O2 Detoxification and Signaling"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMalcolm Jackson (University of Liverpool, United Kingdom)
"Redox Signaling of Adaptive Responses to Contractile Activity in Skeletal Muscle"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amCarola Neumann (Magee-Womens Research Institute, USA)
"PRDX1 in Redox Regulation of Cancer Signaling"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSarah Stöcker (German Cancer Research Center (DKFZ), Germany)
"Thiol Peroxidase Based Redox Relays"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSignaling Mediated by Reactive Oxygen, Nitrogen and Sulfur Species
Discussion Leaders: Christine Winterbourn (University of Otago, Christchurch, New Zealand) and Trent Tipple (University of Alabama at Birmingham, USA)
7:30 pm - 7:50 pmElizabeth Veal (Newcastle University, United Kingdom)
"Role of Peroxiredoxins in Redox Signaling, Stress Responses and Ageing"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmTakaaki Akaike (Tohoku University Graduate School of Medicine, Japan)
"Cysteinyl-tRNA Synthetase Controls Protein Polysulfidation and Mitochondrial Functions"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMassimo Santoro (VIB Vesalius Research Center, KU Leuven, Belgium)
"Redox Signaling and Metabolism in Angiogenesis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGary Loake (University of Edinburgh, United Kingdom)
"A Central Role for S-Nitrosylation in Plant Immunity"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmRedox Research at the Interface of Environment, Aging and Cancer
Discussion Leaders: Ursula Jakob (University of Michigan, USA) and W. Todd Lowther (Wake Forest School of Medicine, USA)
9:00 am - 9:20 amAnna Rubartelli (IRCCS AOU San Martino IST, Italy)
"Targeting Cellular Stress Responses to Prevent Tumor Onset and Progression: Redox-Related Mechanisms and Preclinical Studies"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMary Helen Barcellos-Hoff (University of California, San Francisco, USA)
"Redox Regulation of TGFβ and Its Implications in Cancer Biology"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJohn Mieyal (Case Western Reserve University, USA)
"The Yin and Yang of Glutaredoxin Homeostasis in Brain Cells: Implications for Parkinson's Disease"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amDavid Gius (Feinberg School of Medicine, Northwestern University, USA)
"SIRT3 Is a Mitochondrial Fidelity Protein Directing the Metabolic Stress Response"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amBeatriz Alvarez (University of the Republic, Uruguay)
"Reaction of Thiols with Conjugated Nitrolinoleic Acid"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJesalyn Bolduc (Wake Forest School of Medicine, USA)
"Unlocking the Mystery of Variable Hyperoxidation Sensitivity in Peroxiredoxins: Two Novel, Key Motifs"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThiols and Antioxidant Defense in Bacteria, Plants and Beyond
Discussion Leaders: Luise Krauth-Siegel (Heidelberg University, Germany) and Andreas Meyer (University of Bonn, Germany)
7:30 pm - 7:50 pmJoris Messens (VIB, Vrije Universiteit Brussel, Belgium)
"Promiscuity in Thiol Redox Control"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmFrederic Barras (CNRS, France)
"How to Keep Fe-S Clusters Delivery Efficient Under Iron Limitation (and Other Difficulties)?"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmGloria Muday (Wake Forest University, USA)
"The Role of Flavonols as Antioxidants Protecting Pollen from High Temperature-Induced ROS"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmLimei Zhang (University of Nebraska-Lincoln, USA)
"The WhiB Proteins in Stress Response in Mycobacterium tuberculosis"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmEdward Chouchani (Dana-Farber Cancer Institute, USA)
"Mitochondrial ROS Regulate Thermogenic Energy Expenditure and Sulfenylation of UCP1"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible, in part by 1R13AG053038-01 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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