Applications for this meeting must be submitted by March 29, 2015. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.
The Multi-Drug Efflux Systems Gordon Research Conference will be held in conjunction with the Multi-Drug Efflux Systems Gordon-Kenan Research Seminar
. Those interested in attending both meetings must submit an application for the GKRS in addition to an application for the GRC. Please refer to the Multi-Drug Efflux Systems GKRS web page for more information.
Transport of solutes (e.g., ions, nutrients and metabolites) across the cellular membrane is a fundamentally important process for living cells to maintain their metabolic homeostasis. Active efflux is a mechanism responsible for moving toxic substances and antibiotics out of the cell; this is considered to be a vital part of xenobiotic metabolism. Multidrug efflux systems display the ability to transport a variety of structurally unrelated substrates from a cell and consequently are capable of conferring resistance to a diverse range of chemotherapeutic agents. The importance of efflux is now broadly recognized in clinical settings as it not only contributes to drug resistance in bacterial and mammalian cells, including cancer, but is also important in drug development efforts as it is a defining factor in drug distribution and elimination in tissues and organs. In addition to the efflux mechanisms, systems controlling the influx of solutes also contribute to multi-drug resistance and xenobiotic metabolism. New roles of influx and efflux in adaptation to various environments and signaling continue to emerge.
Participants of the highly appreciated and productive past meetings on multi-drug efflux systems have made unprecedented progress in the understanding of fundamental mechanisms, diversity and functions of multi-drug efflux systems. The 6th meeting will focus on translating this fundamental knowledge into development of novel therapeutic, diagnostic and bioengineering tools. This conference will address both the efflux and influx systems, as the balance of these two counter flows defines and regulates substrate/drug accumulation in all cells and tissues. The conference will start with two keynote lectures provided by internationally recognized leaders in the field of membrane transporters. Following the keynote lectures, scientific sessions will be held to address the roles and biochemical mechanisms of drug transporters in normal physiology and pathology, in drug discovery and development as well as the emerging roles of drug transporters in stems cells, bioengineering and biofuel production.
- Multi-drug efflux pumps in health and disease
- Functional interactions between influx and efflux in health and clinical conditions
- Role of multi-drug efflux in drug discovery and development
- Structure and molecular dynamics of membrane transporters
- Structure-function relationships in multi-drug efflux pumps from microbes and human
- Protein expression, folding, and membrane trafficking of membrane transporters
- Multi-drug efflux pumps in the environment, bioengineering and biofuel production
- Transport proteins in stem cells and clinical implications
For the first time in the history of this meeting, this GRC (April 26 - May 1) will be held in conjunction with the Gordon Research Seminar (GRS) for young scientists (April 25 - 26). For additional information, please kindly visit the GRS web page.
The conference also gratefully acknowledges a personal contribution from William M. Shafer.
A list of preliminary session topics and speakers is displayed below (discussion leaders are noted in italics). The detailed program is currently being developed by the Conference Chair and will be available by December 26, 2014. Please check back for updates.
Keynote Session: Structure and Function of Multi-Drug Efflux Systems
(Victor Ling, Herbert Schweizer / Keynote: Irwin Arias / Keynote: Eitan Bibi)
Multi-Drug Efflux Pumps in Health and Diseases
(Melissa Brown, John Schuetz / Dieter Haeussinger / Ian Paulsen / John Schuetz / Matthias Schwab / Miguel Viveriros / Hannah Wexler)
Functional Interactions Between Influx and Efflux in Health and Clinical Conditions
(Deanna Kroetz / Deanna Kroetz / Tappei Takada / Jashvant Unadkat / Hendrik van Veen)
Role of Multi-Drug Efflux in Drug Discovery and Development
(Ed Buurman, Olga Lomovskaya / Per Artursson / Kim Brouwer / Ed Buurman / Olga Lomovskaya / Larry Sklar)
Structure and Molecular Dynamics of Membrane Transporters
(Klaas Pos / Christian Kandt / Ian Kerr / Osamu Nureki / Klaas Pos)
Structure-Function Relationships in Multi-Drug Efflux Pumps from Microbes and Human
(Eitan Bibi, Osamu Nureki / Vassiliy Bavro / David Hooper / John Golin / Cedric Govaerts / Jean-Michel Jault / Iris Maldener)
Protein Expression, Folding, and Membrane Trafficking of Membrane Transporters
(Suresh Ambudkar / Shigeki Higashiyama / Yinan Wei / Suresh Ambudkar)
Multi-Drug Efflux Pumps in Environment, Bioengineering and Biofuel Production
(Aindrila Mukhopadhyay, Aixin Yan / Anne-Brit Kolsto / Twan Lammers / Aindrila Mukhopadhyay / Wendy Peer / Aixin Yan)
Transporters in Stem Cells and Clinical Implications
(Balazs Sarkadi / Balazs Sarkadi / Hideyuki Saya / Brian Sorrentino)