The Gordon Research Seminar on Fibronectin, Integrins and Related Molecules is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.
This GRS is a platform for junior scientists to
present and discuss their research on the roles, mechanisms, and dynamics of
cell-matrix interactions in development, homeostasis, and disease. The seminar
encompasses a range of topics from the single molecule level to animal models,
including cell migration, cell adhesion, cell phenotype changes, and a variety
This GRS was held in conjunction with the "Fibronectin, Integrins & Related Molecules" Gordon Research Conference (GRC)
. Refer to the associated GRC program page
for more information.
Final Meeting Program
|2:00 pm - 5:00 pm||Arrival and Check-in|
|3:30 pm - 3:45 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:45 pm - 4:30 pm||Matrix Adhesion and Cancer Invasion|
|Discussion Leader: Johanna Ivaska (University of Turku, Finland)|
|3:45 pm - 4:05 pm||Tobias Zech (University of Liverpool, United Kingdom)|
"Matrix Adhesion Site Composition Regulates Nuclear-Force-Coupling to Drive Polarised Cell Migration"
|4:05 pm - 4:10 pm||Discussion|
|4:10 pm - 4:25 pm||Sarah Palmer (Cancer Research UK Beatson Institute, United Kingdom)|
"A Proteomic Approach to Identify Endosomal Cargoes Controlling Cancer Invasiveness"
|4:25 pm - 4:30 pm||Discussion|
|4:30 pm - 6:00 pm||Poster Session|
|7:30 pm - 9:30 pm||Cell Migration - Dissecting the Key Players|
|Discussion Leader: Roy Zent (Vanderbilt University Medical Center, USA)|
|7:30 pm - 7:45 pm||Nisha Mohd Rafiq (Mechanobiology Institute, Singapore)|
"Myosin II-Dependent Suppression of Podosomes by an ARNO-ARF1 Signaling Axis"
|7:45 pm - 7:50 pm||Discussion|
|7:50 pm - 8:05 pm||Gregory Goreczny (SUNY Upstate Medical University, USA)|
"Hic-5 Promotes Mammary Tumor Progression Through Remodeling of the Extracellular Matrix"
|8:05 pm - 8:10 pm||Discussion|
|8:10 pm - 8:25 pm||Jennifer Allen (University of Manchester, United Kingdom)|
"Integrin-Driven Invasion in Ovarian Cancer"
|8:25 pm - 8:30 pm||Discussion|
|8:30 pm - 8:45 pm||Louisiane Perrin (Temple University, USA)|
"Role of Soluble Cues in Extracellular Matrix Degradation During Cancer Metastasis"
|8:45 pm - 8:50 pm||Discussion|
|8:50 pm - 9:05 pm||Mary-Kate Hayward (Barts Cancer Institute, Queen Mary University of London, United Kingdom)|
"Functional Significance of Integrin avb6 and Fibronectin in DCIS-Myoepithelial Cells: Role in Progression to Invasion"
|9:05 pm - 9:10 pm||Discussion|
|9:10 pm - 9:25 pm||Nicolas Rabas (Cancer Research UK Beatson Institute, United Kingdom)|
"Glutaminolysis: A New Pro-Invasive Role"
|9:25 pm - 9:30 pm||Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||ECM Dynamics and Cell Phenotype|
|Discussion Leader: Charles Streuli (University of Manchester, United Kingdom)|
|9:00 am - 9:15 am||Maqsood Ahmed (University of Edinburgh, United Kingdom)|
"Extracellular Matrix in the Developing Ventral Midbrain"
|9:15 am - 9:20 am||Discussion|
|9:20 am - 9:35 am||Amanda Haage (University of British Columbia, Canada)|
"Modulation of Integrin-Based Cell-Matrix Adhesion via Talin Autoinhibition Regulates Cell Behavior and Migration In Vivo"
|9:35 am - 9:40 am||Discussion|
|9:40 am - 9:55 am||Ambika Kurbet (Institute for Stem Cell Biology and Regenerative Medicine, India)|
"Sterile Inflammation Enhances ECM Degradation in Integrin β1 KO Embryonic Skin"
|9:55 am - 10:00 am||Discussion|
|10:00 am - 10:15 am||Natasha Boel (Rhodes University, South Africa)|
"Investigating the Mechanism of Fibronectin Turnover: Identifying a Role for LRP1 and Hsp90"
|10:15 am - 10:20 am||Discussion|
|10:20 am - 10:35 am||Sophie Smolders (Hasselt University, Belgium)|
"Age-Specific Function of Alpha5Beta1 Integrin in Microglial Migration During Early Colonization of the Developing Mouse Cortex"
|10:35 am - 10:40 am||Discussion|
|10:40 am - 10:55 am||David Novo (Cancer Research UK Beatson Institute, United Kingdom)|
"Microvesicle-Mediated Mutant p53 Gain-of-Function in Cancer and Stromal Cells"
|10:55 am - 11:00 am||Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Keynote Session: Plasticity of Cell-Matrix Interactions|
|Discussion Leader: Christine-Maria Horejs (Karolinska Institutet, Sweden)|
|1:30 pm - 2:10 pm||Peter Friedl (Radboud University Medical Center, The Netherlands)|
"Plasticity of Cell-Matrix Interactions: Lessons from Solving Controversy"
|2:10 pm - 2:30 pm||Discussion|
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|
Funding for this conference was made possible by 1R13AR071167-01 the National Institutes of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.