SATURDAY |
1:30 pm - 4:30 pm | Arrival and Check-in |
3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
3:15 pm - 4:00 pm | Keynote Presentation |
| Discussion Leader: Sean Gill (Western University/Lawson Health Research Institute) |
3:15 pm - 3:45 pm | Gillian Murphy (University of Cambridge)
"The metalloprotease roller coaster: what lies ahead?"
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3:45 pm - 4:00 pm | Discussion |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | Regulation of metalloproteinase localization and function in development and disease |
| Discussion Leaders: Johanne Dubail (Cleveland Clinic Lerner Research Institute) and Trista Robichaud (University of Texas Health Science Center)
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5:30 pm - 5:45 pm | Sarah Dombernowsky (University of Copenhagen)
"A functional genomic screen identifies a novel regulator of ADAM17 subcellular localization and ectodomain shedding activity"
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5:45 pm - 5:50 pm | Discussion |
5:50 pm - 6:05 pm | Mary Dear (Vanderbilt University)
"Drosophila MMPs regulate trans-synaptic signaling, synaptic architecture and neurotransmission strength"
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6:05 pm - 6:10 pm | Discussion |
6:10 pm - 6:25 pm | Salvatore Santamaria (Imperial College London)
"Isolation of inhibitory antibodies of ADAMTS-5 from a phage display library"
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6:25 pm - 6:30 pm | Discussion |
6:30 pm - 6:45 pm | Antoine Cominelli (Universite catholique de Louvain - de Duve Institute)
"Matrix Metalloproteinase-27 is retained in the endoplasmic reticulum by its specific C-terminal extension"
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6:45 pm - 6:50 pm | Discussion |
6:50 pm - 7:05 pm | Ashley Weiss (University of Toronto)
"Quadruple Timp deficiency impacts post-natal survival, skeletal homeostasis and hematopoiesis"
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7:05 pm - 7:10 pm | Discussion |
7:10 pm - 7:25 pm | Matthew Deberge (Geisel School of Medicine at Dartmouth College)
"MAPK/ERK-dependent T-cell receptor signaling induces ADAM17 proteolytic processing of TNF receptor 2"
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7:25 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
SUNDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | From Cocaine to Cancer: Metalloproteinases in Disease |
| Discussion Leaders: Antoine Dufour (University of British Columbia) and Alisha Mendonsa (Vanderbilt University)
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9:00 am - 9:15 am | Alexander Smith (Medical University of South Carolina)
"MMPs-2 and -9 mediate synaptic plasticity accompanying relapse to cocaine seeking"
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9:15 am - 9:20 am | Discussion |
9:20 am - 9:35 am | Stephanie Gauci (Murdoch Childrens Research Institute)
"Blocking collagenolysis prevents aggrecan loss more effectively than blocking aggrecanolysis in the aggrecan interglobular domain, in vitro and in vivo"
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9:35 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Tobias Zech (Beatson Institute for Cancer Research)
"Actin-hotspot mediated reversible clustering of MT1-MMP at invasive pseudopods is required to drive breast cancer cell invasion"
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9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Roosmarijn Vandenbroucke (VIB - Ghent University)
"Role of matrix metalloproteinases in inflammation-induced epithelial barrier disruption"
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10:15 am - 10:20 am | Discussion |
10:20 am - 10:35 am | Beatriz Morancho (Vall D'Hebron Institute of Oncology)
"ADAM17 mediates the pro-tumorigenic effect of p95HER2-induced senescent cells"
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10:35 am - 10:40 am | Discussion |
10:40 am - 10:55 am | Catherine Ong (Imperial College London)
"Neutrophil MMP-8/-9 cause matrix destruction in human TB and are regulated by an AMPK-dependent pathway"
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10:55 am - 11:00 am | Discussion |
11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
12:30 pm | Lunch |
1:30 pm - 2:30 pm | Career Panel: "To Infinity and Beyond: A glimpse into what you can do with a graduate education!" |
| Discussion Leader: Gillian Murphy (University of Cambridge) |
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- Howard Crawford (Mayo Clinic Florida)
- Marie Kveiborg (University of Copenhagen)
- Jonathan Larkin (GlaxoSmithKline)
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2:30 pm - 3:00 pm | Evaluation Period |
| Fill out GRS Evaluation Forms |
3:00 pm | Gordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm. |