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Molecular Pharmacology (GRS)
Gordon Research Seminar

Understanding GPCR Function from Structural Biology to In Vivo Models

Dates

March 11-12, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
Daniel J. Shiwarski & Kelsie Eichel

Meeting Description

The Gordon Research Seminar on Molecular Pharmacology is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

Young scientists and senior investigators (discussion leaders) who are at the forefront of their field will discuss new advancements of 3 main aspects of GPCRs biology: i) Molecular basis of activation and function; ii) Cellular signalling and trafficking; and iii) Physiological and pathological processes.

Related Meeting

This GRS was held in conjunction with the "Molecular Pharmacology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmHow GPCR Structure Influences Function
Through the identification and study of GPCR protein structure, many important works have revealed how structure can influence receptor function. In this session, we will explore the structural basis for GPCR signaling, and how alterations in this structure can determine function.
Discussion Leader: Roger Sunahara (University of California, San Diego School of Medicine, USA)
3:15 pm - 3:20 pmIntroduction by Discussion Leader: How GPCR Structure Influences Function
3:20 pm - 3:35 pmNaomi Latorraca (Stanford University, USA)
"Structural Basis for Arrestin Activation by G Protein-Coupled Receptors"
3:35 pm - 3:40 pmDiscussion
3:40 pm - 3:55 pmAnat Levit (University of California, San Francisco, USA)
"2A but Not 2B: Towards Structure-Based Discovery of New Serotonin Receptor Modulators"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmThe GPCR Tool Kit: Novel Techniques and Tools for GPCR Research
In all research, having the right tools can make or break a project. In this session, we will explore several novel tools and techniques that have been developed to aid the progress of GPCR research.
Discussion Leader: Bryan Roth (UNC School of Medicine, University of North Carolina at Chapel Hill, USA)
5:30 pm - 5:35 pmIntroduction by Discussion Leader: Novel Techniques and Tools for GPCR Research
5:35 pm - 5:50 pmJoshua Ziarek (Harvard Medical School, USA)
"Deciphering G Protein-Coupled Receptor (GPCR) Signal Transduction Through Solution NMR"
5:50 pm - 5:55 pmDiscussion
5:55 pm - 6:10 pmElena Lesca (ETH Zurich, Switzerland)
"Jumping Spider Rhodopsin, a New Tool for Optogenetics"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:30 pmQuynh Mai (Monash Institute of Pharmaceutical Sciences / University of Nottingham, United Kingdom)
"The Use of Fluorescence Correlation Spectroscopy to Characterise Lipidated Ligands"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:50 pmCarl White (University of Western Australia, Australia)
"Using BRET and Nluc to Monitor Endogenous Protein Interactions and Receptor Trafficking"
6:50 pm - 6:55 pmDiscussion
6:55 pm - 7:00 pmIntroduction by Discussion Leader: Trafficking and Signaling: Location Matters
7:00 pm - 7:15 pmSana Siddig (University of Wuerzburg, Germany)
"Super-Resolution Microscopy Reveals the Spatial Organization of mGlu4 Receptors at Presynaptic Active Zones"
7:15 pm - 7:20 pmDiscussion
7:20 pm - 7:30 pmGeneral Discussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amGPCR Signaling, Trafficking, and In Vivo Approaches
It is becoming increasingly evident that GPCRs can signal from not only the cell surface, but intracellular compartments. For this reason, the trafficking and localization of GPCRs likely plays a large role in GPCR physiology. Additionally, model systems are essential in determining how basic research can translate into clinical interventions. In this session, we will be presented with work highlighting these topics.
Discussion Leaders: Laura Bohn (The Scripps Research Institute, USA) and JoAnn Trejo (University of California, San Diego, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader: Trafficking and Signaling: Location Matters
9:05 am - 9:20 amSofia Cabezudo (Centro de Biología Molecular Severo Ochoa (CBMSO), Universidad Autónoma de Madrid, Spain)
"Gq-Coupled GPCR Pathways Open New Avenues for the Modulation of Autophagy"
9:20 am - 9:25 amDiscussion
9:25 am - 9:40 amSilvia Sposini (Imperial College London, United Kingdom)
"APPL1 Integrates Regulated GPCR Sorting and Signaling from the Very Early Endosome"
9:40 am - 9:45 amDiscussion
9:45 am - 9:50 amIntroduction by Discussion Leader: In Vivo Approaches and Biased Agonism
9:50 am - 10:05 amJo-Hao Ho (The Scripps Research Institute, USA)
"Characterization of Novel Biased KOR Agonist-Mediated Cell Signaling"
10:05 am - 10:10 amDiscussion
10:10 am - 10:25 amNicole Scholz (Institute of Biochemistry, Leipzig University, Germany)
"The Adhesion-GPCR Latrophilin/dCirl Affects the Development of the Drosophila NMJ"
10:25 am - 10:30 amDiscussion
10:30 am - 10:45 amBianca Plouffe (Universite de Montreal, Canada)
"Human Melatonin Type 2 Receptor Structural Insights Revealed by Natural Variants"
10:45 am - 10:50 amDiscussion
10:50 am - 11:00 amGeneral Discussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: A Look into the Future of GPCR Research
During this session, we will discuss the highlights from the talks and poster session through small group interactions and a panel discussion comprised of the discussion leaders. Attendees will be divided into 4 groups centered around their relevant session topics to recap the conference events with their discussion leader. Following this, we will reconvene and hold an open panel discussion about the future of GPCR research moderated by the conference chairs.
Discussion Leaders: Daniel Shiwarski (Carnegie Mellon University, USA) and Kelsie Eichel (University of California, San Francisco, USA)
1:30 pm - 1:50 pmBreakout Group Discussions
1:50 pm - 2:20 pmPanel Discussion
"The Future of GPCR Research"
  • Laura Bohn (The Scripps Research Institute, USA)
  • Bryan Roth (UNC School of Medicine, University of North Carolina at Chapel Hill, USA)
  • Roger Sunahara (University of California, San Diego School of Medicine, USA)
  • JoAnn Trejo (University of California, San Diego, USA)
2:20 pm - 2:30 pmClosing Remarks
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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