|1:30 pm - 4:30 pm||Arrival and Check-in|
|3:00 pm - 3:15 pm||Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair|
|3:15 pm - 4:00 pm||How GPCR Structure Influences Function|
|Through the identification and study of GPCR protein structure, many important works have revealed how structure can influence receptor function. In this session, we will explore the structural basis for GPCR signaling, and how alterations in this structure can determine function.|
|Discussion Leader: Roger Sunahara (University of California, San Diego School of Medicine, USA)|
|3:15 pm - 3:20 pm||Introduction by Discussion Leader: How GPCR Structure Influences Function|
|3:20 pm - 3:35 pm||Naomi Latorraca (Stanford University, USA)|
"Structural Basis for Arrestin Activation by G Protein-Coupled Receptors"
|3:35 pm - 3:40 pm||Discussion|
|3:40 pm - 3:55 pm||Anat Levit (University of California, San Francisco, USA)|
"2A but Not 2B: Towards Structure-Based Discovery of New Serotonin Receptor Modulators"
|3:55 pm - 4:00 pm||Discussion|
|4:00 pm - 5:30 pm||Poster Session|
|5:30 pm - 7:30 pm||The GPCR Tool Kit: Novel Techniques and Tools for GPCR Research|
|In all research, having the right tools can make or break a project. In this session, we will explore several novel tools and techniques that have been developed to aid the progress of GPCR research.|
|Discussion Leader: Bryan Roth (UNC School of Medicine, University of North Carolina at Chapel Hill, USA)|
|5:30 pm - 5:35 pm||Introduction by Discussion Leader: Novel Techniques and Tools for GPCR Research|
|5:35 pm - 5:50 pm||Joshua Ziarek (Harvard Medical School, USA)|
"Deciphering G Protein-Coupled Receptor (GPCR) Signal Transduction Through Solution NMR"
|5:50 pm - 5:55 pm||Discussion|
|5:55 pm - 6:10 pm||Elena Lesca (ETH Zurich, Switzerland)|
"Jumping Spider Rhodopsin, a New Tool for Optogenetics"
|6:10 pm - 6:15 pm||Discussion|
|6:15 pm - 6:30 pm||Quynh Mai (Monash Institute of Pharmaceutical Sciences / University of Nottingham, United Kingdom)|
"The Use of Fluorescence Correlation Spectroscopy to Characterise Lipidated Ligands"
|6:30 pm - 6:35 pm||Discussion|
|6:35 pm - 6:50 pm||Carl White (University of Western Australia, Australia)|
"Using BRET and Nluc to Monitor Endogenous Protein Interactions and Receptor Trafficking"
|6:50 pm - 6:55 pm||Discussion|
|6:55 pm - 7:00 pm||Introduction by Discussion Leader: Trafficking and Signaling: Location Matters|
|7:00 pm - 7:15 pm||Sana Siddig (University of Wuerzburg, Germany)|
"Super-Resolution Microscopy Reveals the Spatial Organization of mGlu4 Receptors at Presynaptic Active Zones"
|7:15 pm - 7:20 pm||Discussion|
|7:20 pm - 7:30 pm||General Discussion|
|7:30 am - 8:30 am||Breakfast|
|9:00 am - 11:00 am||GPCR Signaling, Trafficking, and In Vivo Approaches|
|It is becoming increasingly evident that GPCRs can signal from not only the cell surface, but intracellular compartments. For this reason, the trafficking and localization of GPCRs likely plays a large role in GPCR physiology. Additionally, model systems are essential in determining how basic research can translate into clinical interventions. In this session, we will be presented with work highlighting these topics.|
|Discussion Leaders: Laura Bohn (The Scripps Research Institute, USA) and JoAnn Trejo (University of California, San Diego, USA)|
|9:00 am - 9:05 am||Introduction by Discussion Leader: Trafficking and Signaling: Location Matters|
|9:05 am - 9:20 am||Sofia Cabezudo (Centro de Biología Molecular Severo Ochoa (CBMSO), Universidad Autónoma de Madrid, Spain)|
"Gq-Coupled GPCR Pathways Open New Avenues for the Modulation of Autophagy"
|9:20 am - 9:25 am||Discussion|
|9:25 am - 9:40 am||Silvia Sposini (Imperial College London, United Kingdom)|
"APPL1 Integrates Regulated GPCR Sorting and Signaling from the Very Early Endosome"
|9:40 am - 9:45 am||Discussion|
|9:45 am - 9:50 am||Introduction by Discussion Leader: In Vivo Approaches and Biased Agonism|
|9:50 am - 10:05 am||Jo-Hao Ho (The Scripps Research Institute, USA)|
"Characterization of Novel Biased KOR Agonist-Mediated Cell Signaling"
|10:05 am - 10:10 am||Discussion|
|10:10 am - 10:25 am||Nicole Scholz (Institute of Biochemistry, Leipzig University, Germany)|
"The Adhesion-GPCR Latrophilin/dCirl Affects the Development of the Drosophila NMJ"
|10:25 am - 10:30 am||Discussion|
|10:30 am - 10:45 am||Bianca Plouffe (Universite de Montreal, Canada)|
"Human Melatonin Type 2 Receptor Structural Insights Revealed by Natural Variants"
|10:45 am - 10:50 am||Discussion|
|10:50 am - 11:00 am||General Discussion|
|11:00 am - 12:30 pm||Poster Session|
|Coffee will be served in the poster area from 11:00 am - 11:30 am|
|1:30 pm - 2:30 pm||Mentorship Component: A Look into the Future of GPCR Research|
|During this session, we will discuss the highlights from the talks and poster session through small group interactions and a panel discussion comprised of the discussion leaders. Attendees will be divided into 4 groups centered around their relevant session topics to recap the conference events with their discussion leader. Following this, we will reconvene and hold an open panel discussion about the future of GPCR research moderated by the conference chairs.|
|Discussion Leaders: Daniel Shiwarski (Carnegie Mellon University, USA) and Kelsie Eichel (University of California, San Francisco, USA)|
|1:30 pm - 1:50 pm||Breakout Group Discussions|
|1:50 pm - 2:20 pm||Panel Discussion|
|"The Future of GPCR Research"|
- Laura Bohn (The Scripps Research Institute, USA)
- Bryan Roth (UNC School of Medicine, University of North Carolina at Chapel Hill, USA)
- Roger Sunahara (University of California, San Diego School of Medicine, USA)
- JoAnn Trejo (University of California, San Diego, USA)
|2:20 pm - 2:30 pm||Closing Remarks|
|2:30 pm - 3:00 pm||Evaluation Period|
|Fill in GRS Evaluation Forms|
|3:00 pm||Seminar Concludes|