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Immunology of Fungal Infections
Gordon Research Conference

Basic Mechanisms and Translational Implications

Dates

January 18-23, 2015

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Bruce S. Klein & Bernhard Hube

Vice Chairs:
Mihai Netea & George Deepe

Meeting Description

Fungal diseases are a major cause of morbidity and mortality in healthy and immune-compromised individuals. A finely tuned immune response is critical, since either insufficient or exaggerated responses undermine the host's ability to eradicate fungal infection. Major strides have been made in understanding the innate and adaptive components underlying protective and non-protective mechanisms of immunity. Newfound recognition of the immunological roles of nutrient limitation, abiotic stress, non-hematopoietic cells, co-evolution of fungal-host interactions, and trafficking of intracellular cargo in phagocytes has lead to novel insights about mechanisms that restrain fungi or that cause immunopathology. Recent work demonstrates that the host microbiota shapes the immune system and modulate its interactions with fungi. These discoveries allow a better understanding of the factors that regulate disease susceptibility, including genetic variation of immune-response genes, and provide a basis for strategies involving immunotherapy and vaccination. This conference will bring together the world's leading researchers investigating antifungal immunity, in a setting ideal for promoting cross-disciplinary discussions and collaborations. This will provide a compelling and informative meeting covering the latest advances in the field and the most pressing issues to be tackled.

Related Meeting

This GRC was held in conjunction with the "Immunology of Fungal Infections" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Immunogenetics of Fungal Disease
Discussion Leader: Jean-Paul Latge (Institut Pasteur, France)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:10 pmSteven Holland (National Institutes of Health, NIAID)
"Human Fungal Infection: We Are All Geneticists Now"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmAnne Puel (INSERM, France)
"Genetic Determinism of Fungal Diseases in Humans"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKeynote: Luigina Romani (University of Perugia, Italy)
"Immunity to Fungi in the Genomic-Metagenomic Era"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmComponents of Innate Immunity to Fungi
Discussion Leader: Sarah Gaffen (University of Pittsburgh)
9:00 am - 9:20 amSalome Leibundgut-Landmann (ETH Zürich, Switzerland)
"IL-17-Mediated Immunity to Candida albicans"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAmariliz Rivera (Rutgers New Jersey Medical School)
"Inflammatory Monocytes Orchestrate Innate Antifungal Immunity in the Lung"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amFrank Van De Veerdonk (Radboud University Medical Center, Netherlands)
"NOD Receptors and Invasive Aspergillosis, Which One to Target?"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amTobias Hohl (Memorial Sloan-Kettering Cancer Center)
"MyD88 and CARD9: Action at Different Sites and Times During Respiratory Fungal Infection"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amChristopher Mody (University of Calgary, Canada)
"Fungal Killing by NK cells"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJessica Quintin (Radboud University Medical Centre, Netherlands)
"Immunological Imprinting of Candida albicans/ß-glucan Induced Trained Immunity and Beyond"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Heather Clark (Case Western Reserve University)
"Calprotectin Controls A. fumigatus Hyphal Growth and Corneal Infection Through Zinc and Manganese Sequestration"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInnate Sensing and Signaling: PRRs and Beyond
Discussion Leader: Karl Kuchler (Medical University Vienna, Austria)
7:30 pm - 7:50 pmGordon Brown (University of Aberdeen, United Kingdom)
"Bruce and Bernie: Six Degrees of Separation and the Link with CLRs"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmTeunis Geijtenbeek (Universiteit Van Amsterdam, Netherlands)
"C-type Lectin Receptors that Regulate Fungal Immunity"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJurgen Rhuland (Technische Universitat Munchen, Germany)
"Innate Immune Signals in Anti-Fungal Defence"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSarah Gaffen (University of Pittsburgh)
"IL-17 Signal Transduction and Immunity to Candidiasis"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructures and Signals that Impact Fungal Immunity
Discussion Leader: Mairi Noverr (Louisiana State University School of Dentistry)
9:00 am - 9:20 amSho Yamasaki (Kyushu University, Japan)
"Recognition of Fungal Pathogens by C-type Lectin Receptors"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amNeil Gow (University of Aberdeen, United Kingdom)
"Turning On and Switching Off Protective Inflammatory Responses to Fungal Cells"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amJean-Paul Latge (Institut Pasteur, France)
"Functional Duality of the Polysaccharides of the Cell Wall of Aspergillus fumigatus"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amRobert Cramer (Dartmouth College)
"HIF1-α Mediated Innate Pulmonary Defense to Aspergillus fumigatus"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMarcel Wuethrich (University of Wisconsin, Madison)
"MyD88 and Priming of Antifungal T cells"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmKarl Kuchler (Medical University Vienna, Austria)
"The Fungal Host Immune Response by an Intracellular Kinase Controls T cell Polarization and Virulence"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmRobert Wheeler (University of Maine)
"Host and Pathogen Determinants of Candida Infection in the Transparent Zebrafish Model"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdaptive and Maladaptive Immunity to Fungi
Discussion Leader: Gordon Brown (University of Aberdeen, United Kingdom)
7:30 pm - 7:50 pmStuart Levitz (University of Massachusetts Medical School)
"Exploiting the Fungal Achilles’ Heel to Develop a Vaccine Against Cryptococcus"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDaniel Kaplan (University of Minnesota)
"Skin DC and Anti-C. albicans Th differentiation"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmLiise-Anne Pirofski (Albert Einstein College of Medicine)
"B Cell and Antibody Immunity to Cryptococcus neoformans"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: J Scott Fites (University of Wisconsin, Madison)
"A Failure to Communicate: How Blastomyces dermatitidis Stifles the Cross Talk of Innate Immunity"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Kirsten Nielsen (University of Minnesota)
"Chitin Triggers Pathologic Th2 Responses to Cryptococcal Infection"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMycobiome, Mammalian Surfaces, and Non-Hematopoietic Lining Cells
Discussion Leader: Scott Filler (Los Angeles Biomedical Research Institute)
9:00 am - 9:20 amDavid Underhill (Cedars-Sinai Medical Center)
"Interactions of the Immune System with Commensal Fungi"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMairi Noverr (Louisiana State University School of Dentistry)
"Host and Microbial Factors Promoting Synergistic Mortality During Polymicrobial Intra-Abdominal Infections with Candida albicans and Staphylococcus aureus"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amSuzanne Noble (University of California, San Francisco)
"Phenotypic Switches Yield Insights into Candida albicans Commensalism and Pathogenesis"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amJulian Naglik (Kings College London, United Kingdom)
"Activation of Epithelial Cells by a Putative Pore Forming Toxin in Candida albicans"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amTeresa Zelante (University of Perugia, Italy)
"Shaping T-helper Cell Plasticity with Fungi"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amTerry Wright (University of Rochester School of Medicine)
"Epithelial Cell Regulation of Immunity to Pneumocystis"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Melissa Garcia (Brooklyn College)
"Functional Amyloids in Host-Fungal Interactions"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Melissa Ida Palmieri (University of Perugia, Italy)
"Microbiota Regulation of Fungal Infectivity"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmHost-Fungal Pathogen Interactions: Systems Biology and Beyond
Discussion Leader: Luigina Romani (University of Perugia, Italy)
7:30 pm - 7:50 pmDuccio Cavalieri (Fondazione Edmund Mach, Italy)
"Variation in Immune Function Shapes Human Fungal Populations at the Strain Level"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMarcio Rodrigues (CDTS/Fiocruz, Brazil)
"Immunological Activity of Fungal Polysaccharides: Biological Functions Beyond the Classic Structural Properties"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmNorman Pavelka (Singapore Immunology Network, Singapore)
"Evolutionary Dynamics of Host-Fungal Interactions"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmLouise Rollins-Smith (Vanderbilt University Medical Center)
"Immune Evasion by an Ancient Fungal Pathogen of Amphibians"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular Parasitism
Discussion Leader: Stuart Levitz (University of Massachusetts Medical School)
9:00 am - 9:20 amJatin Vyas (Harvard Medical School)
"The Role of CD82 in Macrophages in the Host Defense against Candida albicans"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRobin May (University of Birmingham, United Kingdom)
"The Ins and Outs of Cryptococcosis: Understanding Phagocyte Escape by Pathogenic Fungi"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amAnita Sil (University of California, San Francisco)
"Manipulation of Phagocytic Cell Biology by the Intracellular Pathogen Histoplasma capsulatum"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amThirumala-Devi Kanneganti (St. Jude Children's Research Hospital)
"Innate Immune Receptors and Candida and Aspergillus Infections"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Mari Shinohara (Duke University School of Medicine)
"Autophagy Enhances NFκB Activity in Specific Tissue Macrophages to Boost Anti-Fungal Immunity"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Kavitha Subramanian (University of Cincinnati)
"Zinc Regulation by Interleukin-4 Shapes Alternatively Activated Macrophage Phenotype and Promotes Fungal Survival"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Michal Olszewski (University of Michigan / VA Ann Arbor Healthcare)
"Cryptococcus neoformans-Induced Macrophage Lysosome Damage Crucially Contributes to Fungal Virulence"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Lydia Kasper (Hans Knoell Institute, Germany)
"Intracellular Survival, Damage and Escape: Interaction of Candida glabrata and C. albicans with Macrophages"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHarnessing Immunity to Fungi in the Clinic
Discussion Leader: Suzanne Noble (University of California, San Francisco)
7:30 pm - 7:50 pmScott Filler (Los Angeles Biomedical Research Institute)
"Targeting the Aspergillus fumigatus Invasin"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMichail Lionakis (National Institutes of Health)
"Phagocyte-Mediated Innate Immunity during Systemic Candidiasis: from the Bench to the Bedside"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJay Kolls (University of Pittsburgh School of Medicine)
"Coordination of Pulmonary Fungal Immunity by CD4+ T-cell Subsets"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Pappanaicken Kumaresan (MD Anderson Cancer Center)
"Bioengineered T Cells to Treat Fungal Diseases"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Martin Jaeger (RadboudUMC Department of Internal Medicine, Netherlands)
"Genetic Variation and Susceptibility to Recurrent Vulvovaginal Candidiasis"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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