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Immunology of Fungal Infections
Gordon Research Conference

Fundamental Insights and Therapeutic Potential: Advances in Understanding the Host-Fungus Interaction

Dates

January 15-20, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
George Deepe & Mihai Netea

Vice Chairs:
Sarah L. Gaffen & Neil Gow

Meeting Description

Fungal diseases remain a growing threat to the health of numerous species from amphibians to mammals. In humans, they cause substantial morbidity and mortality in otherwise healthy or immunocompromised individuals. Fungi threaten the well-being of humans from endogenous or environmental sources. Appropriate orchestration of the immune response is requisite for successful resolution of infection. How this choreography is achieved remains enigmatic. Impaired or exuberant immune responses can thwart effective eradication. Major scientific achievements have catapulted the field to the forefront of microbial immunology. An explosion of insights have uncovered novel aspects regarding the function of components of innate and adaptive immunity. These revealing studies have educated us about effector mechanisms that lead to fungal killing. Conversely, these studies also have highlighted the clever ways in which fungi evade recognition and elimination. Recent work detailing the influence of host cell metabolism, intracellular trafficking, nutrition, epithelial cell function, and the microbiota provides new insights into the host-pathogen interaction and immune control of infection. These are but a few of the examples that illustrate the tremendous progress in the field. Such discoveries provide a strong foundation for deciphering the elements that foster both resistance and susceptibility to infection. Moreover, understanding the immunological basis of the successful host response without causing excessive damage serves as a platform to develop new immunotherapeutic strategies and vaccines to treat or prevent infection. This conference will bring together the world's leading investigators who are exploring antifungal immunity in a setting conducive for exchange of ideas leading to new collaborations. This meeting will underscore the latest advances in the field and the most nettlesome scientific issues that require attention.

Related Meeting

This GRC was held in conjunction with the "Immunology of Fungal Infections" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCutting Edge in Fungal Immunology
Discussion Leader: Gordon Brown (University of Aberdeen, United Kingdom)
7:40 pm - 8:00 pmJean-Paul Latge (Institut Pasteur, France)
"First to Touch, First to Sense?"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmJulian Naglik (King's College London, United Kingdom)
"Epithelial Activation by Candidalysin"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmArturo Zychlinsky (Max Planck Institute for Infection Biology, Germany)
"NETs in Fungal Infections"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmRecognition of Fungi by Innate Cells
Discussion Leader: Salome Leibundgut-Landmann (University of Zurich, Switzerland)
9:00 am - 9:20 amGordon Brown (University of Aberdeen, United Kingdom)
"C-Type Lectins: What's New?"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMichael Lorenz (University of Texas Health Science Center at Houston, USA)
"A Transcriptional Perspective on Interactions Between Macrophages and CUG Clade Species"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amBetty Wu-Hsieh (National Taiwan University, Taiwan)
"Modulation of Innate Cell Antifungal Immunity"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amAmariliz Rivera (Rutgers New Jersey Medical School, USA)
"Distinct Contributions of Type I and III IFNs to Innate Antifungal Immunity"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amBeth Garvy (University of Kentucky College of Medicine, USA)
"Pneumocystis Life Forms Differentially Interact with Innate Immune Cells in the Lungs"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Sarah Gaffen (University of Pittsburgh School of Medicine, USA) and Kirsten Nielsen (University of Minnesota, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImmune-Metabolic Interactions in Fungal Immunity
Discussion Leader: Georgios Chamilos (University of Crete / Institute of Molecular Biology and Biotechnology (IMBB), Greece)
7:30 pm - 7:50 pmRobert Cramer (Dartmouth College, USA)
"Immune Suppression Altered Host Metabolism Promotes Fungal Virulence"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmPeter Murray (St. Jude Children's Research Hospital, USA)
"Influence of Amino Acid Metabolism on Immune Effector and Regulatory Control"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmConstantin Urban (Umea University, Sweden)
"Dual Role of Metal-Related Immunity for Inflammatory Responses and Antifungal Defense"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmTeresa Zelante (University of Perugia, Italy)
"Metabolic Regulation of the Host-Microbe Mutual Airway Tolerance"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHumoral and Cellular Effectors in Fungal Immunity
Discussion Leader: Amariliz Rivera (Rutgers New Jersey Medical School, USA)
9:00 am - 9:30 amBruce Klein (University of Wisconsin-Madison, USA)
"Lung Epithelium and Control of Inhaled Fungal Pathogens"
9:30 am - 9:45 amDiscussion
9:45 am - 10:05 amScott Filler (Los Angeles Biomedical Research Institute, USA)
"Endothelial Cell Invasion by Yeast-Phase Candida spp."
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:05 amChristina Zielinski (Technical University of Munich, Germany)
"Regulation of Human T Helper Cell Functions in Health and Disease by the Microenvironment"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amNancy Keller (University of Wisconsin-Madison, USA)
"Aspergillus/Host Crosstalk Elucidated by the Zebrafish Larval Model"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amMichael Mansour (Massachusetts General Hospital, USA)
"Novel Tools to Study Fungal-Neutrophil Interactions"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMaladaptive Immunity
Discussion Leader: Frank Van De Veerdonk (Radboud University Nijmegen, The Netherlands)
7:30 pm - 7:50 pmGeorgios Chamilos (University of Crete / Institute of Molecular Biology and Biotechnology (IMBB), Greece)
"Novel Molecular Mechanisms Regulating Aspergillus Phagosome Biogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmLeo Joosten (Radboud University Nijmegen, The Netherlands)
"IL-32, a Novel Cytokine in the Host Defense Against Candida albicans"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKirsten Nielsen (University of Minnesota, USA)
"Jekyll and Hyde - Dual Roles of T-Cell Activation in Cryptococcus Infection"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMari Shinohara (Duke University School of Medicine, USA)
"Immune Reconstitution Inflammatory Syndrome (IRIS) Caused by Fungi"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmunogenetics and Pathophysiology of Fungal Immunity
Discussion Leader: Kirsten Nielsen (University of Minnesota, USA)
9:00 am - 9:20 amVinod Kumar (University of Gronigen, The Netherlands)
"Population-Based Cohorts to Patient Cohort: Characterizing Genetic Susceptibility to Candidemia"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDesa Lilic (Newcastle University, United Kingdom)
"Disease Mechanisms Underlying a Broad Clinical Phenotype in CMC Patients with Gain-of-Function STAT1 Mutations"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amAnne Puel (INSERM, France)
"Inborn Errors of Immunity and Susceptibility to Chronic Mucocutaneous Immunity"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amAshraf Ibrahim (Harbor-UCLA Medical Center, USA)
"Targeting Host Receptor and Fungal Ligand Interactions for Novel Mucormycosis Therapies"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amXin Lin (Tsinghua University, China)
"CLR-Induced JNK Activation Impacts Anti-Fungal Innate Immunity"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMycobiome and Host Defense Mechanisms
Discussion Leader: Floyd Wormley (University of Texas at San Antonio, USA)
7:30 pm - 7:50 pmYvonne Huang (University of Michigan, USA)
"The Respiratory Microbiome in Airway Disease: Bacteria and Beyond"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAndrew Koh (University of Texas Southwestern Medical Center, USA)
"Candida albicans Gastrointestinal Colonization Resistance in the Mammalian Host"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSalome Leibundgut-Landmann (University of Zurich, Switzerland)
"Dynamic Interactions Between Candida albicans and the Host Mucosa"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDavid Underhill (Cedars-Sinai Medical Center, USA)
"Commensal Fungi: Old Friends and New Players"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInnate and Adaptive Memory in Fungal Infection
Discussion Leader: Stuart Levitz (University of Massachusetts Medical School, USA)
9:00 am - 9:20 amCaitlin Pepperell (University of Wisconsin-Madison, USA)
"Investigating the Genetic Basis of Susceptibility to Blastomycosis"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJessica Quintin (Institut Pasteur, France)
"Monocyte Memory to Beta-Glucans and Beyond"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:50 amFloyd Wormley (University of Texas at San Antonio, USA)
"Induction of Long-Lived Trained Immunity by Macrophages Against Cryptococcosis In Vivo"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amFrank Van De Veerdonk (Radboud University Nijmegen, The Netherlands)
"Acquired Immunodeficiencies and Increasing Susceptibility to Fungal Infection"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amChad Steele (University of Alabama at Birmingham, USA)
"Immunopathogenesis During Chronic Fungal Exposure"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHost-Directed Therapy: From Vaccines to Immunotherapy
Discussion Leader: Jatin Vyas (Harvard Medical School, USA)
7:30 pm - 7:50 pmStuart Levitz (University of Massachusetts Medical School, USA)
"Fungal Vaccines: The Baker Delivers the Goods"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAdilia Warris (University of Aberdeen, United Kingdom)
"Defective Antifungal Immunity in Chronic Granulomatous Disease and Cystic Fibrosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPeter Williamson (National Institutes of Health, USA)
"Challenges of a Paradoxical Immune Response in Non-HIV Cryptococcal Meningitis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJack Edwards (Harbor-UCLA Medical Center, USA)
"Update on the Development of a Vaccine for Candida: Clinical Trials and Mechanism of Action"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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