SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Identifying Mediators of Reprogramming |
| Discussion Leader: Kathrin Plath (UCLA) |
7:40 pm - 8:20 pm | Sir John Gurdon (Gurdon Insitute)
"Reprogramming of mammalian nuclei in amphibian oocytes" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Joanna Wysocka (Stanford University)
"Cross-talk between chromatin and cis-regulatory elements in pluripotency" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Reprogramming the Germ Line |
| Discussion Leader: Ken Zaret (UPenn) |
9:00 am - 9:40 am | Hans Scholer (Max Planck Institute)
"Induction of pluripotency by OCT4" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Azim Surani (Gurdon Institute)
"Germ line, stem cells and reprogramming" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Oliver Hobert (Columbia University)
"Direct conversion of germ cells into specific neuron types" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetic/Epigenetic Mechanisms of Reprogramming |
| Discussion Leader: Ihor Lemischka (Mt. Sinai School of Medicine) |
7:30 pm - 8:10 pm | Ken Zaret (University of Pennsylvania)
"Parameters affecting the initial genome occupancy by pluripotency factors in human somatic cells" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Alex Meissner (Harvard University)
"DNA methylation dynamics in stem cells and development" |
9:10 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Direct Reprogramming Between Somatic Cell States |
| Discussion Leader: Bill Lowry (UCLA) |
9:00 am - 9:40 am | Stephen Tapscott (Fred Hutchinson Cancer Research Center)
"Common and distinct mechanisms for myogenic and neurogenic conversion" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Hanna Mikkola (UCLA)
"Uncovering latent cardiogenic potential in hemogenic endothelium and endocardium" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Mick Bhatia (McMaster Stem Cell and Cancer Research Institute)
"Programming human hematopoietic progenitors" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | More Direct Reprogramming Between Somatic Cell States |
| Discussion Leader: Lorenz Studer (Sloan Kettering Memorial Cancer Institute) |
7:30 pm - 8:10 pm | Marius Wernig (Stanford University)
"Making neurons by crossing major lineage boundaries" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Magdalena Goetz (Ludwig-Maximilians-University Munich)
"A core program of neurogenesis and its role in direct neuronal reprogramming" |
9:10 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Modeling Human Disease With Reprogrammed Cells |
| Discussion Leader: Andras Nagy (Samuel Lunenfeld Research Institute) |
9:00 am - 9:40 am | Lorenz Studer (Memorial Sloan Kettering) |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Ricardo Dolmetsch (Stanford University) |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Joe Wu (Stanford)
"Cardiac iPSCs for Modeling Disease Mechanism, Drug Screening, and Cell Therapy" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Reprogramming and Dedifferentiation in Cancer |
| Discussion Leader: Danqing Pei (GIBH) |
7:30 pm - 8:10 pm | Dino Morvinski (The Salk Institute, Verma Lab)
"Glioblastomas can originate by reprogramming of differentiated cells in the brain" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Short Talk: Flaminia Talos (Columbia University)
"Directed differentiation and transdifferentiation to prostate epithelia" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Short Talk: Shila Mekhoubad (Harvard Stem Cell Institute)
"Erosion of Dosage Compensation Impacts Human iPS Cell Disease Modeling" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Molecular Mechanisms of Pluripotency and Reprogramming - I |
| Discussion Leader: Konrad Hochedlinger (Harvard University) |
9:00 am - 9:40 am | Andras Nagy (Samuel Lunenfeld Research Institute)
"Reprogramomics" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Duanqing Pei (GIBH)
"Reprogramming through vitamin C and histone modification enzymes" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Ihor Lemischka (Mt. Sinai Medical School)
"Pluripotency, Etc." |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Molecular Mechanisms of Pluripotency and Reprogramming - II |
| Discussion Leader: Thomas Zwacka (Baylor College of Medicine) |
7:30 pm - 8:10 pm | Jose Silva (University of Cambridge)
"Reprogramming mechanisms of Oct4 and Nanog" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Short Talk: Jianlong Wang (Mt. Sinai School of Medicine)
"Reprogramming Logic from the Oct4/Nanog Interactome" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Short Talk: Rupa Sridharan (University of Wisconsin-Madison)
"Histone methylation changes, identified by mass spectrometry, improve reprogramming efficiency" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |