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Thiol-Based Redox Regulation and Signaling (GRS)
Gordon Research Seminar

Redox Biology in Diseases of Aging: Fundamental Mechanisms and Therapeutic Potential

Dates

August 6-7, 2016

Location

Stoweflake Conference Center
Stowe, VT

Organizers

Chairs:
Edward T. Chouchani & Jade T. Mims

Meeting Description

The Gordon Research Seminar on Thiol-Based Redox Regulation and Signaling is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

This Gordon Seminar will focus on redox modification of protein thiols and the role they play in a broad range of cellular processes. Because altered thiol-based signaling is central to aging and aging-associated diseases, and modified redox homeostasis defines age-related dysfunction, there will be a particular focus on mechanisms that underlie this relationship.In particular, emphasis will be on the role of thiol-based redox regulation in cancer, inflammation, metabolic disorders, and in the context of environmental stress. Discussion topics will range from the chemical basis for reactive oxygen species and reactive nitrogen species and thiol-based interactions, to the study of how redox modifications integrate into cellular signaling and physiology, as well as on the development of novel tools to study thiol modifications and thiol-dependent processes.

Related Meeting

This GRS was held in conjunction with the "Thiol-Based Redox Regulation and Signaling" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmRedox Signaling in Cancer and Metabolic Disease
Discussion Leader: Nina Kaludercic (National Research Council, Italy)
3:45 pm - 4:00 pmLeticia Roma (German Cancer Research Center, Germany)
"In Vivo 'Redox Maps' in Diabetic Mouse Models"
4:00 pm - 4:05 pmDiscussion
4:05 pm - 4:25 pmIsaac Harris (Harvard Medical School, USA)
"Functional Profiling of Antioxidant Liabilities in Cancer"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSpatiotemporal Dynamics of Redox Signalling
Discussion Leader: Bruno Manta (Brigham and Women's Hospital / Harvard Medical School, USA)
7:30 pm - 7:45 pmCrystal Conaway (University of South Carolina, USA)
"Compartmentalization of Mitochondrial Glutathione in Saccharomyces cerevisiae Under Severe Redox Stress"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:10 pmSasha De Henau (University Medical Center Utrecht, The Netherlands)
"Cellular Polarization as a Model to Study Spatiotemporal Redox Regulation"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmDaria Ezerina (German Cancer Research Centre (DKFZ), Germany)
"Cytoprotective Effects of NAC Are Mediated by H2S"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmLoes van Dam (University Medical Center Utrecht, The Netherlands)
"The Peroxiredoxin Redox-Relay in Cellular Redox Signal Specificity"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmEvanna Mills (Trinity College, Dublin, Ireland)
"Repurposing Mitochondria from ATP Production to ROS Generation via Reverse Electron Transport Induces a Pro-Inflammatory Phenotype in Macrophages"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amNovel Methods for Assessing Thiol Redox Status
Discussion Leader: Jesalyn Bolduc (Wake Forest School of Medicine, USA)
9:00 am - 9:15 amKyle Cole (Boston College, USA)
"Synthesis and Characterization of Triazine-Based Covalent Inhibitors of Protein Disulfide Isomerase A1"
9:15 am - 9:20 amDiscussion
9:20 am - 9:40 amElizabeth Hinchy (MRC Mitochondrial Biology Unit, United Kingdom)
"Utilising Click PEGylation to Assess Protein Thiol Redox States by Cysteine Trapping Followed by Immunoblotting"
9:40 am - 9:45 amDiscussion
9:45 am - 10:05 amYu-Hsuan Kuo (University of Michigan, Ann Arbor, USA)
"Chemoselective Profiling of Cysteine Sulfinic Acids in Complex Proteomes"
10:05 am - 10:10 amDiscussion
10:10 am - 10:30 amJeffrey Lawson (Wake Forest School of Medicine, USA)
"A Structural and Biochemical Analysis of Human Peroxiredoxin-3: A Unique Member of the Prx Family"
10:30 am - 10:35 amDiscussion
10:35 am - 10:55 amLia Randall (Universidad de la República, Uruguay)
"Structural and Functional Characterization of the Nitrated Form of Peroxiredoxin 2"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Navigating Your Scientific Career Path
Discussion Leaders: Edward Chouchani (Dana-Farber Cancer Institute, USA) and Jade Mims (Wake Forest School of Medicine, USA)
1:30 pm - 2:30 pmPanel Discussion
"Navigating Your Scientific Career Path"
  • Joris Messens (VIB, Vrije Universiteit Brussel, Belgium)
  • Melissa Kemp (Georgia Institute of Technology, USA)
  • Eranthie Weerapana (Boston College, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible, in part by 1R13AG053038-01 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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