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Mammalian DNA Repair (GRS)
Gordon Research Seminar

Frontiers of Mammalian Genomic Stability in Human Health

Dates

February 18-19, 2017

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chairs:
Abigail Lubin & Molly Hardebeck

Meeting Description

The Gordon Research Seminar on Mammalian DNA Repair is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to foster the scientific development of young investigators through presentations on the most current research in the field, a panel demonstrating a variety of career paths, and a highly-engaging environment that encourages scientific discussion and networking. The topics presented will cover mammalian DNA repair from basic mechanisms to clinical implications with an emphasis on the intersections of mechanistic and therapy-focused studies.

Related Meeting

This GRS was held in conjunction with the "Mammalian DNA Repair" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Final Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: DNA Signaling
Discussion Leader: Abigail Lubin (Icahn School of Medicine at Mount Sinai, USA)
3:45 pm - 4:15 pmJacqueline Barton (California Institute of Technology, USA)
"DNA Signaling"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechanisms of DNA Repair Pathways
Discussion Leaders: Upasana Roy (Stony Brook University, USA) and Nodar Makharashvili (University of Texas at Austin, USA)
7:30 pm - 7:50 pmPamela Sara Head (Emory University, USA)
"SIRT2 Directs DNA-PKcs in the DNA Damage Response"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMichael Howard (National Institute of Environmental Health Sciences, NIH, USA)
"Polymerase β Uses Its Lyase Domain in a Processive Search for DNA Damage"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMichael Murata (University of California, Irvine, USA)
"Fluorescence Lifetime Mapping of NADH Reveals the Effect of PARP Signaling on Energy Metabolism in Response to DNA Damage"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmPreston Williams (University of California, Riverside, USA)
"Identification and Characterizations of Novel 8,5'-Cyclo-2'-Deoxypurine-Binding Proteins by Mass Spectrometry"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amTranslational Implications of Impaired DNA Repair Pathways
Discussion Leaders: Nicole Williams (University of California, Riverside, USA) and Amy Whitaker (University of Kansas Medical Center, USA)
9:00 am - 9:20 amNicolas Hoch (University of Sussex, United Kingdom)
"XRCC1 Mutation Is Associated with PARP1 Hyperactivation and Cerebellar Ataxia"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMarta Popovic (University of Oxford, United Kingdom)
"DNA-Protein Crosslink Repair in Humans: SPRTN Is a Novel Mammalian Protease with the Central Role in DPC Repair Pathway"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJohn Reynolds (University of Birmingham, United Kingdom)
"Identification and Characterisation of Mutations Associated with Microcephalic Dwarfism"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amManasi Ratnaparkhe (German Cancer Research Centre (DKFZ), Germany)
"Genomic Profiling of AT-TALL Patients Reveals Tight Link Between ATM Mutations and Chromothripsis"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Panel
Discussion Leader: Molly Hardebeck (Eli Lilly and Company, USA)
1:30 pm - 2:30 pmPanel Discussion
"Scientific Career Options"
  • Priscilla Cooper (Lawrence Berkeley National Laboratory, USA)
  • Jessica Downs (Institute of Cancer Research, United Kingdom)
  • Patricia Opresko (University of Pittsburgh, USA)
  • Samuel Wilson (National Institute of Environmental Health Sciences, NIH, USA)
  • Beth Moorefield (Nature Structural & Molecular Biology, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13CA213969-01 from the National Cancer Institute (NCI), the National Institute on Aging (NIA) and the National Institutes of Environmental Health Sciences (NIEHS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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