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Quantitative Genetics & Genomics (GRS)
Gordon Research Seminar

Interpreting Genetic Variation in Context

Dates

February 25-26, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Amelie Baud & Gregor Gorjanc

Meeting Description

The Gordon Research Seminar on Quantitative Genetics and Genomics is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. The meeting will provide the opportunity for young investigators from the fields of human, animal, plant and model organism genetics and genomics to interact with each other and with current leaders in these fields.

The focus of this meeting is the context-dependency of associations between genetic and phenotypic variation. Context includes but is not limited to population/genetic background, physical, chemical, and psychological environment, developmental phase, tissue, and cell type. We will discuss how understanding the context dependency of genetic associations can be used for fundamental understanding of biology and its use in artificial selection and medicine. Statistical, computational, and experimental methods will be presented.

A mentoring lunch will be organized on the second day. Small groups composed of a few attendees plus one of the panel speakers will discuss topics related to careers in quantitative genetics.

Related Meeting

This GRS was held in conjunction with the "Quantitative Genetics & Genomics" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Quantitative Genetics and the Search for the Missing Heritability: The Long (and Ongoing) Search for Quantitative Trait Variation
Discussion Leader: Ann Stapleton (University of North Carolina at Wilmington, USA)
3:45 pm - 4:15 pmBruce Walsh (University of Arizona, USA)
"Quantitative Genetics and the Search for the Missing Heritability: The Long (and Ongoing) Search for Quantitative Trait Variation"
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetic Architecture
Discussion Leaders: Frank Albert (University of Minnesota, USA) and Julia Steinberg (Wellcome Trust Sanger Institute, United Kingdom)
7:30 pm - 7:45 pmChristine O'Connor (University of Oregon, USA)
"Using Experimental Evolution and Next Generation Sequencing to Dissect the Genetic Architecture of Acute Stress Response in the Nematode Caenorhabditis remanei"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmZoe Migicovsky (Dalhousie University, Canada)
"Quantifying the Genetic Basis of Leaf Shape in Apple"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmSarah Signor (University of Southern California, USA)
"Convergent Evolution of Male Specific Color Patterns in Drosophila"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmFranziska Kreuchwig (Max Delbrueck Center for Molecular Medicine (MDC), Helmholtz Association, Germany)
"Dissecting the Genetic Basis of Transcriptional and Translational Regulation in Heart Failure"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmGregory Keele (University of North Carolina at Chapel Hill, USA)
"Accounting for Haplotype Uncertainty in QTL Mapping of Multiparental Populations Using Multiple Imputation"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAdrien Butty (Canada)
"Optimization of the Genetic Diversity of a Sequenced Population to Improve Imputation Accuracy of Rare Variants"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amInvestigating the Role of Context / Mentorship Component: Panel Discussion
Discussion Leaders: Bruce Walsh (University of Arizona, USA) and Yvonne Wientjes (Wageningen University and Research, The Netherlands)
9:00 am - 9:15 amJoseph Gage (University of Wisconsin-Madison, USA)
"Mapping Variants Associated with Phenotypic Stability in Maize"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amTroy Rowan (University of Missouri, USA)
"Local Genetic Adaptation in United States Bos Taurus Cattle"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amJovana Marjanovic (Wageningen University, The Netherlands)
"Modelling the Co-Evolution of Indirect Genetic Effects and Inherited Variability"
9:55 am - 10:00 amDiscussion
10:00 am - 11:00 amPanel Discussion
"Keys to Success"
  • Frank Albert (University of Minnesota, USA)
  • Natalia De Leon (University of Wisconsin-Madison, USA)
  • Michel Georges (University of Liege, Belgium)
  • Ann Stapleton (University of North Carolina at Wilmington, USA)
  • Bruce Walsh (University of Arizona, USA)
  • Nicolas Heslot (Limagrain, France)
  • Peter Visscher (University of Queensland, Australia)
  • Emma Huang (Janssen R&D, USA)
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmModelling Variability
Discussion Leaders: Natalia De Leon (University of Wisconsin-Madison, USA) and Wesley Crouse (University of North Carolina at Chapel Hill, USA)
1:30 pm - 1:45 pmMichael Turchin (University of Chicago, USA)
"Bayesian Multivariate Re-Analysis of Large Genetic Studies Identifies Many Novel Associations"
1:45 pm - 1:50 pmDiscussion
1:50 pm - 2:05 pmRachel Moore (Wellcome Trust Sanger Institute - EBI Single-Cell Genomics Centre, United Kingdom)
"TreeLMM: Modelling Heterogeneity of Genetic Effects"
2:05 pm - 2:10 pmDiscussion
2:10 pm - 2:25 pmValerie Arboleda (University of California, Los Angeles, USA)
"Shared Genetic Basis of Complex and Rare Disease"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible (in part) by 1R13 HG009449-01 from the National Human Genome Research Institute (NHGRI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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