SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Advancing Our Understanding of ADAMs and iCLiPs Networks and Molecular Mechanisms |
| Discussion Leader: Marcia Moss (BioZyme, Inc.) |
7:40 pm - 8:20 pm | Keynote Lecture: Michael Wolfe (Harvard University)
"γ-Secretase and the Mechanism of Alzheimer's Disease"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Keynote Lecture: Paul Saftig (University of Kiel) |
9:10 pm - 9:20 pm | Discussion |
9:30 pm - 10:30 pm | Opening Reception |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Roles of ADAMs and iCLiPs in Development and Beyond |
| Discussion Leader: Matthew Freeman (University of Oxford) |
9:00 am - 9:30 am | Carl Blobel (Hospital for Special Surgery)
"iRhoms: Key Regulators of ADAM17/EGFR and ADAM17/TNF Signaling"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Matthew Freeman (University of Oxford)
"The Rhomboid-Like Family in Mammals"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Walter Stoecker (Johannes Gutenberg Universitaet)
"Ovastacin and Fetuin-B: Gate Keepers Regulating Sperm/Egg Fusion in Mammals"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Joaquin Arribas (Vall d'Hebron Institute of Oncology (VHIO))
"Ectodomain Shedding During Oncogene-Induced Senescence" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ADAM- and iCLiP-Dependent Signaling Pathways |
| Discussion Leader: Stefan Rose-John (Christian-Albrechts-Universität zu Kiel) |
7:30 pm - 8:00 pm | Rama Khokha (University of Toronto)
"Timp Influence on ADAM-Dependent Signaling"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Agnes Noël (University of Liege)
"Membrane Type-4 MMP and Its Cell Membrane Landscape for Outside-In Signaling Regulation" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Stefan Rose-John (Christian-Albrechts-Universität zu Kiel) |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Structural Biology of iCLiPs and Sheddases |
| Discussion Leader: Charles (Chuck) Sanders (Vanderbilt University) |
9:00 am - 9:30 am | Sin Urban (Howard Hughes Medical Institute)
"The Implications of Catalyzing Proteolysis Inside the Membrane"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Ana-Nicoleta Bondar (Freie Universität Berlin)
"Dynamics of Substrate Binding to GlpG Rhomboid Proteases" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Joanne Lemieux (University of Alberta)
"Structural Insight into Regulation of Rhomboid Protease Activity"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Charles (Chuck) Sanders (Vanderbilt University)
"Structural Control of C99 Cleavage by Membrane Composition"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | iCLiP and Sheddase Modulators and Drug Discovery |
| Discussion Leader: Bart De-Strooper (VIB Center for the Biology of Disease) |
7:30 pm - 8:00 pm | Bart De-Strooper (VIB Center for the Biology of Disease) |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Harald Steiner (German Center for Neurodegenerative Diseases (DZNE))
"Modulation of Gamma-Secretase Activity" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Bob Lazarus (Genentech Inc.)
"Noncanonical Modulators of BACE1 Activity" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | iCLiP and Sheddase Substrate Identification |
| Discussion Leader: Stefan Lichtenthaler (German Center for Neurodegenerative Diseases (DZNE)) |
9:00 am - 9:30 am | Stefan Lichtenthaler (German Center for Neurodegenerative Diseases (DZNE))
"Proteomic RIP Protease Substrate Identification In Vitro and In Vivo"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jim Wells (University of California at San Francisco (UCSF))
"N-Terminomics: Identification of Protease Substrates in Complex Biological Sample" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Maria Garcia-Parajo (ICFO - The Institute of Photonic Sciences)
"Optical Nano-Tools to Investigate the Spatiotemporal Organization of Cell Surface Receptors in Living Cells" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Angus McQuibban (University of Toronto)
"Regulating the Regulator; Rhomboid Activity in Mitochondrial Health and Death" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regulation of Ectodomain Shedding and RIP |
| Discussion Leader: Christian Haass (Ludwig-Maximilians Universität München) |
7:30 pm - 7:55 pm | Christian Haass (Ludwig-Maximilians Universität München)
"Regulated Intramembrane Proteolysis of TREM2 and Its Role in FTD and FTD-Like Syndrome"
|
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | TBA |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:50 pm | Short Talk: Regina Fluhrer (LMU Munich & DZNE)
"Signal-Peptide Peptidase Like 3 (SPPL3) Is a Novel Regulator of Cellular N-Glycosylation"
|
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:05 pm | Short Talk: Wendy Gordon (Harvard Medical School)
"RIP-Ping Apart Notch Signaling"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Short Talk: Christoph Becker-Pauly (University of Kiel)
"Shedding of Meprin Metalloproteases by ADAM10/17 for the Regulation of EGFR Activation"
|
9:20 pm - 9:25 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | iCLiPs and Sheddases in Infectious Diseases |
| Discussion Leader: Mike Glickman (Memorial Sloan Kettering Cancer Center) |
9:00 am - 9:30 am | Jin Ye (UT Southwestern Medical Center)
"RIP of CREB3L1, an Innate Antiviral Response and Beyond"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | David Sibley (Washington University School of Medicine)
"The Function of Rhomboid Proteases in Protozoan Parasites" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Mike Glickman (Memorial Sloan Kettering Cancer Center)
"Control of Mycobacterium tuberculosis Virulence by the Rip1 S2P" |
11:30 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Short Talk: Marius Lemberg (University of Heidelberg)
"The Rhomboid Pseudoprotease Derlin Primes Signal Peptide Peptidase for ER-Associated Protein Degradation"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | TBA (Short Talk) |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | TBA (Short Talk) |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | iCLiPs and Sheddases: From Bench Toward Bedside |
| Discussion Leader: Bob Lazarus (Genentech Inc.) |
7:30 pm - 8:00 pm | Qing-Xiang (Amy) Sang (Florida State University)
"Survival Analysis of Cell Surface Metalloproteases in Human Cancer and Strategies for Drug Targeting and Personalized Medicine" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Irit Sagi (Weizmann Institute of Science)
"Controlling ECM Invasive Diseases by Attenuating Membrane Collagenase Activity" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:30 pm | Closing Remarks |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |