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Pancreatic Diseases
Gordon Research Conference

Frontiers in Pancreatic Research

Dates

July 19-24, 2015

Location

Mount Holyoke College
South Hadley, MA

Organizers

Chair:
Michele Solimena

Vice Chair:
Diane M. Simeone

Meeting Description

The first GRC on Pancreatic Diseases was held in July, 2013 at Mount Holyoke College, South Hadley, MA, USA. The distinctive concept of this GRC is to bring together basic and physician scientists at the forefront of research in all aspects of pancreatic diseases, including diabetes, pancreatic cancer and pancreatitis. Theses complex diseases represent a major threat for human health and society and advancement in their understanding and treatment requires an interdisciplinary approach. Given the close developmental and physiological relatedness of pancreatic exocrine and endocrine cells and the significant epidemiological association between pancreatic cancer and diabetes, it is especially felt that a forum for scientific exchange among leaders in these fields provides a unique opportunity to establish new collaborations and foster much needed progress in these research areas and translation of this information into medical practice.

Following the resounding success of the first conference, the second GRC "Pancreatic Diseases" will take place July 19-24, 2015 at Mount Holyoke College South Hadley, MA USA. The program we have assembled is first-rate, benefitting from the contribution of international world-class female and male scientists engaged in research relevant to different aspects of pancreatic diseases. As for all GRCs, the guiding principle of this Conference is the presentation of new, unpublished results and the free, unhampered discussion that follows. This tradition of freely sharing ideas is due in large part to GRC's "off the record" policy which prohibits photography or tape recording of sessions or the publication of conference proceedings. Participation of young scientists, including PhD students, postdocs and junior group leaders is especially welcome, with opportunities of short talks and partial reimbursement of conference fees and traveling costs for selected poster abstracts.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmAutoimmunity in Pancreatic Disorders
Discussion Leader: Piero Marchetti (Università di Pisa, Italy)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:20 pmDecio Eizirik (Université Libre de Bruxelles, Belgium)
"Pancreatic Beta Cell Autonomous Immunity and the Triggering of Insulitis in Type 1 Diabetes"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pmSuresh Chari (Mayo Clinic, USA)
"Autoimmune Diseases of the Exocrine Pancreas"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPancreatic Cell Identity
Discussion Leader: Diane Simeone (University of Michigan, USA)
9:00 am - 9:30 amLori Sussel (Columbia University, USA)
"Transcriptional Mechanisms Regulating Beta Cell Identity"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amDanwei Huangfu (Sloan Kettering Institute, USA)
"Gene Editing in Human Pluripotent Stem Cells to Study Pancreatic Development and Diabetes"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amFrancesca Spagnoli (Max Delbrueck Center for Molecular Medicine, Germany)
"Pancreatic Development: Cell Fate Choices and Plasticity"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amRebecca Beer (Johns Hopkins University, USA)
"Centroacinar Cells Are Progenitors that Contribute to Endocrine Pancreas Regeneration"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmHeiko Lickert (Helmholtz Zentrum Muenchen GmbH, Germany)
"Beta Cell Development and Heterogeneity"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJin Li (CeMM GmbH, Austria)
"An Approved Drug Induces a Beta-Like Phenotype in Alpha Cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdaption of Beta Cells to Hyperglycemia
Discussion Leader: Anke Schulte (Sanofi Frankfurt, Germany)
7:30 pm - 8:00 pmYuval Dor (Hebrew University - Hadassah Medical School, Israel)
"Mechanisms of Pancreatic Beta Cell Growth and Failure"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRohit Kulkarni (Harvard Medical School, USA)
"Approaches to Enhance Functional Beta Cell Mass"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAlan Attie (University of Wisconsin - Madison, USA)
"Genes from Mouse Genetics that Affect the Insulin Secretory Pathway"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInflammation in Pancreatic Diseases
Discussion Leader: Fred Gorelick (Yale School of Medicine, USA)
9:00 am - 9:30 amMinoti Apte (University of New South Wales, Australia)
"Pancreatic Stellate Cells: Key Roles in Acute and Chronic Pancreatitis"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amShannon Liudahl (Oregon Health and Science University, USA)
"B Cells Regulate Tissue Damage During Pancreatitis"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amMarina Pasca di Magliano (University of Michigan, USA)
"Oncogenic Kras and the Pancreatic Cancer Microenvironment"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amJacques Izard (Forsyth Institute, USA)
"Multisites Oral Microbiome Investigation of Pancreatitis and Neoplasms of Extrahepatic Bile Duct and Pancreas"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmGregory Beatty (University of Pennsylvania, USA)
"Immunoregulatory Networks in Pancreatic Carcinoma"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmElsie Foglio (Yale University School of Medicine, USA)
"Effects of NSAIDS (Salicylate Derivatives) on AMP-Activated Kinase Activity in an In Vitro Model of Acute Pancreatitis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNews on Endocrine and Exocrine Secretion
Discussion Leader: Mike German (University of California, San Francisco, USA)
7:30 pm - 8:00 pmHerbert Gaisano (University of Toronto, Canada)
"Role of Inhibitory SNAREs in Secretion in the Endocrine and Exocrine Pancreas"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmRegina Kuliawat (Albert Einstein College of Medicine, USA)
"The GEFs Kalirin/Trio Contribute to Beta-Granule Remodeling and Exocytosis"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pmTetsuro Izumi (Institute for Molecular and Cellular Regulation, Gunma University, Japan)
"Novel Functions of Rab27 Effector Proteins in Insulin Granule Exocytosis"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmFlorian Ehehalt (Technische Universität Dresden, Germany)
"Blood Glucose Homeostasis in the Course of Partial Pancreatectomy – Evidence for Surgically Reversible Diabetes Induced by Cholestasis"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenomics and Genetics of Pancreatic Diseases
Discussion Leader: Tom Wilkie (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:30 amAndrew Biankin (University of Glasgow, United Kingdom)
"Clinical Application of Cancer Genomes"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amYiannis Drosos (St Jude Children's Research Hospital, USA)
"ATM Loss and KrasG12D Cooperate to Promote Widely Metastatic Pancreatic Ductal Adenocarcinoma in Mice"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amAndrew Hattersley (University of Exeter, United Kingdom)
"Insights into Pancreatic Development and Function from Gene Discovery in Neonatal Diabetes"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amAmita Tiyaboonchai (University of Pennsylvania, USA)
"The Role of GATA6 in Human Endoderm and Pancreatic Development from Human Pluripotent Stem Cells"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmMarco Falasca (Curtin University, Australia)
"The LPI/GPR55 Axis as a Therapeutic Target in Pancreatic Cancer"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmNathan Krah (University of Utah, USA)
"PTF1A Limits Pancreatic Tumor Initiation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmPancreas Development and Pancreatic Diseases
Discussion Leader: Christopher Wright (Vanderbilt University Medical Center, USA)
7:30 pm - 8:00 pmSteven Leach (Memorial Sloan Kettering Cancer Center, USA)
"Reciprocal Cell-Cell Signaling in Pancreatic Cancer Initiation"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMaike Sander (University of California, San Diego, USA)
"Location Matters: The Underappreciated Role of Niche Cues in Pancreas Morphogenesis and Cell Fate Determination"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMike German (University of California, San Francisco, USA)
"Growth of the Pancreatic Endocrine Compartment"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Insight into Pancreatic Cancer
Discussion Leader: Andrew Biankin (University of Glasgow, United Kingdom)
9:00 am - 9:30 amTeresa Brentnall (University of Washington, USA)
"Molecular Susceptibility to Pancreatic Cancer"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amHeather Schofield (University of Michigan, USA)
"Bmi1 Is Required for the Initiation of Pancreatic Cancer Through an Ink4a-Independent Mechanism"
9:55 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amMichael Hollingsworth (University of Nebraska Medical Center, USA)
"Molecular Features of Pancreatic Cancer Progression to Metastasis"
11:00 am - 11:10 amDiscussion
11:10 am - 11:25 amNilotpal Roy (University of California, San Francisco, USA)
"Functional Switch in Brg1 Activity Between Benign and Malignant Stages of Pancreatic Ductal Adenocarcinoma"
11:25 am - 11:30 amDiscussion
11:30 am - 12:00 pmAndrew Rhim (University of Michigan Medical School, USA)
"Single Nucleotide Variants in mRNA in Pancreatic Cancer"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAudrey Hendley (Johns Hopkins University, USA)
"p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNovel Approaches for Pancreatic Research
Discussion Leader: Howard Crawford (University of Michigan, USA)
7:30 pm - 8:00 pmAnne Grapin-Botton (DanStem, University of Copenhagen, Denmark)
"Individual Cell Contributions to Pancreas Organogenesis: Stochasticity, Heterogeneity and Self-Organization"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMaureen Anne Gannon (Vanderbilt University Medical Center, USA)
"Modulation of Intrinsic and Extrinsic Beta Cell Characteristics to Promote Replication and Regeneration"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmSunitha Nagrath (University of Michigan, USA)
"Microfluidic Technologies for Liquid Biopsy: Emerging Tools for Isolation, Characterization and Expansion of CTCs"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13DK106939-01 from the NIDDK. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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