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Pancreatic Diseases
Gordon Research Conference

Frontiers in Pancreatic Research

Dates

July 19-24, 2015

Location

Mount Holyoke College
South Hadley, MA

Organizers

Chair:
Michele Solimena

Vice Chair:
Diane M. Simeone

Application Deadline

Applications for this meeting must be submitted by June 21, 2015. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The first GRC on Pancreatic Diseases was held in July, 2013 at Mount Holyoke College, South Hadley, MA, USA. The distinctive concept of this GRC is to bring together basic and physician scientists at the forefront of research in all aspects of pancreatic diseases, including diabetes, pancreatic cancer and pancreatitis. Theses complex diseases represent a major threat for human health and society and advancement in their understanding and treatment requires an interdisciplinary approach. Given the close developmental and physiological relatedness of pancreatic exocrine and endocrine cells and the significant epidemiological association between pancreatic cancer and diabetes, it is especially felt that a forum for scientific exchange among leaders in these fields provides a unique opportunity to establish new collaborations and foster much needed progress in these research areas and translation of this information into medical practice.

Following the resounding success of the first conference, the second GRC "Pancreatic Diseases" will take place July 19-24, 2015 at Mount Holyoke College South Hadley, MA USA. The program we have assembled is first-rate, benefitting from the contribution of international world-class female and male scientists engaged in research relevant to different aspects of pancreatic diseases. As for all GRCs, the guiding principle of this Conference is the presentation of new, unpublished results and the free, unhampered discussion that follows. This tradition of freely sharing ideas is due in large part to GRC's "off the record" policy which prohibits photography or tape recording of sessions or the publication of conference proceedings. Participation of young scientists, including PhD students, postdocs and junior group leaders is especially welcome, with opportunities of short talks and partial reimbursement of conference fees and traveling costs for selected poster abstracts.

Funding Notice: Funding to help support attendees (graduate students and postdocs) will be available.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmAutoimmunity in Pancreatic Disorders
Discussion Leader: Piero Marchetti (Universita di Pisa, Italy)
7:40 pm - 8:10 pmDecio Eizirik (Université Libre de Bruxelles, Belgium)
"Pancreatic Beta Cell Autonomous Immunity and the Triggering of Insulitis in Type 1 Diabetes"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmSuresh Chari (Mayo Clinic, USA)
"Autoimmune Diseases of the Exocrine Pancreas"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:30 pmShort Talks Selected from Poster Abstracts
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPancreatic Cell Identity
Discussion Leader: Matthias Hebrok (University of California, San Francisco, USA)
9:00 am - 9:30 amLori Sussel (Columbia University, USA)
"Transcriptional Mechanisms Regulating the Maintenance of Beta Cell Identity"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amShort Talks Selected from Poster Abstracts
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amFrancesca Spagnoli (Max Delbrueck Center for Molecular Medicine, Germany)
"Pancreatic Development: Cell Fate Choices and Plasticity"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amShort Talks Selected from Poster Abstracts
11:30 am - 12:00 pmHeiko Lickert (Helmholtz Zentrum Muenchen GmbH, Germany)
"Beta Cell Development and Heterogeneity"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmShort Talks Selected from Poster Abstracts
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAdaption of Beta Cells to Hyperglycemia
Discussion Leader: Anke Schulte (Sanofi Frankfurt, Germany)
7:30 pm - 8:00 pmYuval Dor (Hebrew University - Hadassah Medical School, Israel)
"Mechanisms of Pancreatic Beta Cell Growth and Failure"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRohit Kulkarni (Harvard Medical School, USA)
"Approaches to Enhance Functional Beta Cell Mass"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDomenico Accili (Columbia University, USA)
"Mechanisms of Beta Cell Dedifferentiation in Type 2 Diabetes"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInflammation in Pancreatic Diseases
Discussion Leader: Fred Gorelick (Yale School of Medicine, USA)
9:00 am - 9:30 amMinoti Apte (University of New South Wales, Australia)
"Key Roles in Acute and Chronic Pancreatitis"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amShort Talks Selected from Poster Abstracts
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amLisa Coussens (Oregon Health and Science University, USA)
"Targeting BTK in Pancreas Cancer"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amShort Talks Selected from Poster Abstracts
11:30 am - 12:00 pmGregory Beatty (University of Pennsylvania, USA)
"Immunoregulatory Networks in Pancreatic Carcinoma"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmShort Talks Selected from Poster Abstracts
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNews on Endocrine and Exocrine Secretion
Discussion Leader: Susumo Seino (Kobe University, Japan)
7:30 pm - 8:00 pmHerbert Gaisano (University of Toronto, Canada)
"Role of Inhibitory SNAREs in Secretion in the Endocrine and Exocrine Pancreas"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmShort Talks Selected from Poster Abstracts
8:30 pm - 9:00 pmTetsuro Izumi (Institute for Molecular and Cellular Regulation, Gunma University, Japan)
"Novel Functions of Rab27 Effector Proteins in Insulin Granule Exocytosis"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmShort Talks Selected from Poster Abstracts
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenomics and Genetics of Pancreatic Diseases
Discussion Leader: Tom Wilkie (UT Southwestern Medical Center, USA)
9:00 am - 9:30 amAndrew Biankin (University of Glasgow, United Kingdom)
"Clinical Application of Cancer Genomes"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amShort Talks Selected from Poster Abstracts
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amAndrew Hattersley (University of Exeter, United Kingdom)
"Insights into Pancreatic Development and Function from Gene Discovery in Neonatal Diabetes"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amShort Talks Selected from Poster Abstracts
11:30 am - 12:00 pmTeresa Brentnall (University of Washington, USA)
"Molecular Susceptibility to Pancreatic Cancer"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmShort Talks Selected from Poster Abstracts
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmPancreas Development and Pancreatic Diseases
Discussion Leader: Christopher Wright (Vanderbilt University Medical Center, USA)
7:30 pm - 8:00 pmSteven Leach (Memorial Sloan Kettering Cancer Center, USA)
"Learning About Pancreatic Cancer from Mouse and Zebrafish Embryos"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMaike Sander (University of California, San Diego, USA)
"Epigenetic Determinants of Beta Cell Development, Function and Disease"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmMike German (University of California, San Francisco, USA)
"Growth of the Pancreatic Endocrine Compartment"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Insight into Pancreatic Cancer
Discussion Leader: Dafna Bar-Sagi (NYU School of Medicine, USA)
9:00 am - 9:30 amMarco Falasca (Curtin University, Australia)
"The LPI/GPR55 Axis as a Therapeutic Target in Pancreatic Cancer"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amShort Talks Selected from Poster Abstracts
10:00 am - 10:30 amCoffee Break
10:30 am - 11:00 amMichael Hollingsworth (University of Nebraska Medical Center, USA)
"Molecular Features of Pancreatic Cancer Progression to Metastasis"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amShort Talks Selected from Poster Abstracts
11:30 am - 12:00 pmAndrew Rhim (University of Michigan Medical School, USA)
"Single Nucleotide Variants in mRNA in Pancreatic Cancer"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmShort Talks Selected from Poster Abstracts
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNovel Approaches for Pancreatic Research
Discussion Leader: Howard Crawford (Mayo Clinic Florida, USA)
7:30 pm - 8:00 pmAnne Grapin-Botton (DanStem, University of Copenhagen, Denmark)
"Individual Cell Contributions to Pancreas Organogenesis: Stochasticity, Heterogeneity and Self-Organization"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMaureen Anne Gannon (Vanderbilt University Medical Center, USA)
"Modulation of Intrinsic and Extrinsic Beta Cell Characteristics to Promote Replication and Regeneration"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmSunitha Nagrath (University of Michigan, USA)
"Microfluidic Technologies for Liquid Biopsy: Emerging Tools for Isolation, Characterization and Expansion of CTCs"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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