Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Liquid Biopsy: An Evolving Field
Discussion Leader: Stefanie Jeffrey (Stanford University, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
George Sledge (Stanford University, USA)
"Clinical Utility of Liquid Biopsy"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
Chris Abbosh (Cancer Research UK / University College London, United Kingdom)
"Phylogenetic ctDNA Profiling in Early-Stage NSCLC: A Lung TRACERx Experience"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Rosandra Kaplan (National Institutes of Health, USA)
"Exosome Mediated Immune and Stromal Cell Plasticity in Pre-Metastatic Niche Formation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Isolation Technologies and Tailored Applications
Discussion Leader: Anthony Dickherber (National Cancer Institute, NIH, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Dino Di Carlo (University of California, Los Angeles, USA)
"Phenotypic Liquid Biopsies"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Sonja Loges (University Medical Center Hamburg-Eppendorf, Germany)
"Investigation of Dynamic Changes in CTC Heterogeneity in Lung Cancer to Predict Responses to Checkpoint Inhibitors and Targeted Therapies"
10:15 am - 10:25 am
Discussion
10:25 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Erica Carpenter (University of Pennsylvania, USA)
"Advances in Plasma-Based Liquid Biopsy for Patient Monitoring"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Erica Pratt (University of Minnesota, USA)
"Quantitative High-Sensitivity Multiplex Detection of Rare KRAS Mutations in Liquid Biopsy Samples Using Digital Droplet PCR"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
Jordan Cheng (Univeristy of California, Los Angeles, USA)
"EFIRM-Liquid Biopsy: Noninvasive Ultrasensitive Detection of Oncogenic Mutations in Plasma and Saliva"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Marsha Rosner (University of Chicago, USA) and Erica Pratt (University of Minnesota, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
CTC Subtyping and Propagation to Explore Tumor Biology
Discussion Leader: Marsha Rosner (University of Chicago, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Dario Marchetti (Houston Methodist Research Institute, USA)
"Characterizing CTC Subsets to Combat Breast Cancer Brain Metastasis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Min Yu (University of Southern California, USA)
"Cultured Circulating Tumor Cells Recapitulate Breast Cancer Metastatic Tropism and Reveal Brain Metastasis Drivers"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Sunitha Nagrath (University of Michigan, USA)
"Microfluidic Labyrinth for the Isolation, Characterization and Expansion of CTCs"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Jeannette Huaman (Hunter College, City University of New York, USA)
"Circulating Tumor Cells Display Epithelial-to-Mesenchymal Transition, Loss of MHCI Expression, and Differential Cytokine Secretions"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tumor Clues in Blood and Lymphatics
Discussion Leader: Catherine Alix-Panabieres (Centre Hospitalier Universitaire de Montpellier, France)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Electron Kebebew (Stanford University, USA)
"MicroRNA and CpG Analysis in Blood of Patients with Endocrine Tumors"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Michael Speicher (Medical University of Graz, Austria)
"Epigenetic Traces in Blood"
10:15 am - 10:25 am
Discussion
10:25 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Melody Swartz (University of Chicago, USA)
"Lymph from Melanoma Patients Is Enriched in Tumor-Derived Exosomes, Proteins, and miRNA and Reveals a Protein Signature that Distinguishes Degree of Metastatic Spread"
11:15 am - 11:25 am
Discussion
11:25 am - 11:55 am
Timothy Padera (Massachusetts General Hospital / Harvard Medical School, USA)
"The Role of the Lymphatic System in Cancer Progression"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tools for Biological and Functional Analyses
Discussion Leader: Dario Marchetti (Houston Methodist Research Institute, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Catherine Alix-Panabieres (Centre Hospitalier Universitaire de Montpellier, France)
"Functional Analyses of Circulating Tumor Cells in Cancer Patients"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Scott Manalis (Massachusetts Institute of Technology, USA)
"New Tools for Longitudinal CTC Studies in Mouse Models of Cancer"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Steven Soper (University of Kansas, USA)
"Microfluidics for the Isolation and Analysis of Liquid Biopsy Markers: CTCs, EVs and cfDNA"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Lisa Welter (University of Southern California, USA)
"Investigating the Multimodal Relationship Between Cell-Free DNA and Circulating Tumor Cells in Metastatic Breast Cancer Patients"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tumor Products and Tumor-Educated Products in Circulation
Discussion Leader: Genevieve Boland (Massachusetts General Hospital, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Evi Lianidou (University of Athens, Greece)
"Development and Clinical Applications of Molecular Assays for CTCs and Paired ctDNA"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Thomas Wurdinger (VU University Medical Center, The Netherlands)
"Tumor-Educated Platelets for the Detection of Cancer"
10:15 am - 10:25 am
Discussion
10:25 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
Wilfred Ngwa (Brigham and Women's Hospital / Harvard Medical School, USA)
"Nanoparticle Drones: 4G Technology to Track and Kill Circulating Tumor Cells"
11:15 am - 11:25 am
Discussion
11:25 am - 11:55 am
Anna Krichevsky (Brigham and Women's Hospital, USA)
"Expanding the Repertoire of Peripheral Coding and Non-Coding RNA Biomarkers for Brain Tumors"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Olivia Ruhen (The University of Western Australia, Australia)
"Comprehensive Molecular Analysis of Exosomes and Circulating Tumour DNA in Breast Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tumor-Associated Extracellular Vesicles and Liquid Biopsy
Discussion Leader: Shana Kelley (University of Toronto, Canada)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Marsha Rosner (University of Chicago, USA)
"Tumor Cell Extracellular Vesicles as Breast Cancer Biomarkers"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
David Issadore (University of Pennsylvania, USA)
"Diagnosing Disease with Rare Circulating Exosomes: Finding Heterogeneous, Nanoscale Pins in a Nanoscale Haystack"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Brian Kirby (Cornell University, USA)
"CTCs and Extracellular Shed Vesicles in Cancer: Using Microdevices to Characterize the Effects of Drug Resistance"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Stacey Gifford (IBM Research, USA)
"Isolation of Exosomes by nano-DLD Lab-on-a-Chip Technology for Clinical Applications"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Incorporating Liquid Biopsy into Clinical Trials
Discussion Leader: George Sledge (Stanford University, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Howard Scher (Memorial Sloan Kettering Cancer Center, USA)
"Circulating Tumor Cell Biomarkers for Response and Prediction: Enumeration and Phenogenomics"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
David Miyamoto (Massachusetts General Hospital / Harvard Medical School, USA)
"Molecular Characterization of Circulating Tumor Cells for Precision Cancer Medicine"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Michail Ignatiadis (Institut Jules Bordet, Belgium)
"Liquid Biopsy for Drug Development in Oncology"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Alvin Shi (Massachusetts Institute of Technology, USA)
"Exosomal Transcriptomic Signatures Tracks and Predicts Response to Checkpoint Blockade Immunotherapy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Juntaro Matsuzaki (National Cancer Center Research Institute, Japan)
"Utility of Circulating microRNA Profiles for the Detection and Localization of Cancers in the Early Stage"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Integrating Technology and Applications in Liquid Biopsy
Discussion Leader: Shannon Stott (Massachusetts General Hospital / Harvard Medical School, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Anthony Dickherber (National Cancer Institute, NIH, USA)
"Persistent Technology Challenges for Liquid Biopsies: A Perspective from the NCI"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Costanza Paoletti (Rogel Cancer Center, University of Michigan, USA)
"Exploring Tumor Heterogeneity Within Circulating Tumor Cells"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Klaus Pantel (University Medical Center Hamburg-Eppendorf, Germany)
"Liquid Biopsy in Breast Cancer: From Discovery to Clinical Utility"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure