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Parkinson's Disease
Gordon Research Conference

Emerging Research in the Etiology and Pathogenesis of a Complex Disease

Dates

June 28 - July 3, 2015

Location

Colby-Sawyer College
New London, NH

Organizers

Chair:
David Sulzer

Vice Chair:
Andrew Singleton

Meeting Description

Parkinson’s disease (PD) is the most common motor disorder. Over the past fifteen years, the discovery of disease-causing mutations in a growing number of genes has accelerated the pace of our understanding of disease mechanisms. Simultaneous discoveries in cell biology and immunological processes are rapidly providing insights into the processes that lead to this disease. This creates an exciting series of challenges and opportunities to be addressed by discussion and exchange of ideas. There has to our knowledge never been a basic research conference devoted to Parkinson’s, and this conference will bring together investigators with diverse scientific backgrounds who share an interest in the cellular mechanisms that produce PD and its related disorders. The specific content of the Conference will evolve as our understanding of PD evolves.

For the first Conference, topics will include: The normal function of PD-related genes; The cellular response to toxic protein aggregates; Endoplasmic reticulum stress; Proteasomal and autophagic processes; Neuroimmune pathways; and Prion-like aggregate pathogenesis.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: From Determinants of Selective Neuronal Vulnerability to Possible Neuroprotective Therapy
Discussion Leader: Stanley Fahn (Columbia University, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:35 pmPoster Previews
8:35 pm - 8:45 pmIntroduction by Discussion Leader
8:45 pm - 9:15 pmJames Surmeier (Northwestern University, USA)
"From Determinants of Selective Neuronal Vulnerability to Possible Neuroprotective Therapy"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeuronal Selectivity and Transmission of Pathology
Discussion Leader: Michael Kaplitt (Weill Cornell Medical College, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amAaron Gitler (Stanford University, USA)
"New Insights into Alpha-Synuclein and Retromer Functional Interactions"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amJeffrey Kordower (Rush Medical School, USA)
"Alpha-Synuclein in the Nigrotriatal System: Autonomous Cellular Pathologies and Cell to Cell Transfer"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:50 amVirginia Lee (University of Pennsylvania, USA)
"Transmission of Misfolded α-Synuclein in Synucleinopathies"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amChristian Pifl (Medical University of Vienna, Austria)
"Synaptic Vesicles and Mechanisms of Dopaminergic Neurodegeneration - Studies in Human Striatum"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amDennis Selkoe (Ann Romney Center for Neurologic Diseases, USA)
"Helically-Folded Tetramers as a Physiological Form of Alpha-Synuclein: Implications for Disease Prevention"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmKurt De Vos (University of Sheffield, United Kingdom)
"Increasing Microtubule Acetylation Rescues Axonal Transport and Locomotor Deficits Caused by LRRK2 Roc-COR Domain Mutations"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGene Identification: First Steps to Mechanisms
Discussion Leader: Matthew Farrer (University of British Columbia, Canada)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmAlexis Brice (Inserm, France)
"Homozygosity Mapping in Consanguineous Cases: New Candidate Genes and Implication in the Parkin/PINK1 Mitophagy Pathways"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmMark Cookson (National Institutes of Health, USA)
"Protein Interactions of LRRK2 Explain Risk Factors from GWAS"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmAntony Cooper (Garvan Institute of Medical Research, University of New South Wales, Australia)
"Dysregulation of a Long Noncoding RNA Disrupts Key Pathways in Sporadic Patients"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmAiqun Li (The New York Stem Cell Foundation, USA)
"iPSC-Derived Dopamine Neurons Reveal Differences Between Monozygotic Twins Discordant for Parkinson's Disease"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmToxic Dominant Negatives? Gene Functions
Discussion Leader: Dennis Dickson (Mayo Clinic, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amJacqueline Burre (Weill Cornell Medical College, USA)
"Function and Dysfunction of Synucleins at the Synapse"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amValina Dawson (Johns Hopkins University School of Medicine, USA)
"Lost in Translation"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amGroup Photo / Coffee Break
10:40 am - 11:00 amRobert Edwards (University of California, San Francisco, USA)
"The Membrane Interactions of Alpha-Synuclein"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amSubhojit Roy (University of California, San Diego, USA)
"Applying Quantitative Biology Tools to Alpha-Synuclein"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmLaura Volpicelli-Daley (University of Alabama at Birmingham, USA)
"Formation of α-Synuclein Lewy Neurite-Like Aggregates in Axons Impedes the Transport of Distinct Endosomes"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmPaul Barrett (University of Pittsburgh, USA)
"Alpha-Synuclein Binds TOM20 and Inhibits Mitochondrial Protein Import in Parkinson's Disease"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLoss of Stress-Induced Protection? Recessive Gene Functions
Discussion Leader: Caroline Tanner (University of California, San Francisco, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmTed Dawson (Johns Hopkins University School of Medicine, USA)
"Parsing Molecular Mechanisms of Degeneration"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmEdward Fon (Montreal Neurological Institute / McGill University, Canada)
"Parkin Functions"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmJie Shen (Harvard University, USA)
"LRRK in Autophagy and Dopaminergic Neurons Survival"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmGraziella Cappelletti (Università Degli Studi di Milano, Italy)
"Parkinson's Disease Linked Proteins Modulate Microtubule Function: Is It the Missing Piece in the Pathogenic Pathway?"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDisease Mechanisms in Organelle Transport and Turnover
Discussion Leader: Karen O'Malley (Washington University at St. Louis School of Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amCharleen Chu (University of Pittsburgh, USA)
"Maintaining Dendritic Mitochondrial Homeostasis: A-Kinase Story"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amErika Holzbaur (University of Pennsylvania School of Medicine, USA)
"Axonal Autophagic Processes"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amSusan Lindquist (HHMI / Whitehead Institute / Massachusetts Institute of Technology, USA)
"From Yeast Cells to Patient Neurons: A Powerful Discovery Platform for Combatting Neurodegenerative Diseases"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amThomas Schwarz (Boston Children's Hospital, USA)
"PINK1/Parkin Mitophagy in Neurons"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmRichard Youle (National Institutes of Health, USA)
"How Autophagy Machinery Is Activated and Recruited Downstream of Parkin Ubiquitination of Mitochondria"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmAndrea Bugarcic (University of Queensland, Australia)
"Identification of LRRK2-SNX27-Retromer Complex and Characterization of Its Involvement in Parkinson's Disease Cellular Phenotypes"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmHow Do Aging Processes Fuel Neurodegeneration?
Discussion Leader: Luigi Zecca (Institute of Biomedical Technologies-CNR, Italy)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmAna Maria Cuervo (Albert Einstein College of Medicine, USA)
"Selective Autophagy in the Maintenance of Neuronal Proteostasis"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmMalu Tansey (Emory University, USA)
"Inflammaging: Do Chronic Inflammation and Age-Related Alterations in Immune Function Contribute to Neuroinflammation?"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmZhenyu Yue (Icahn School of Medicine at Mount Sinai, USA)
"Impairment of Autophagy and Synaptic Plasticity in LRRK2-Mediated Pathogenesis"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmOri Lieberman (Columbia University, USA)
"Cell-Type Specific Differences in Chaperone-Mediated Autophagy Activity May Underlie the Selective Susceptibility of Substantia Nigra Dopaminergic Neurons in Parkinson's Disease"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPathological Synaptic Circuitry
Discussion Leader: Mahlon DeLong (Emory University School of Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amStephanie Cragg (University of Oxford, United Kingdom)
"Modulation of Evoked Dopamine Release"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amAnatol Kreitzer (University of California, San Francisco, USA)
"Target-Specific Remodeling of Thalamostriatal Synapses"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amCharles Wilson (University of Texas, San Antonio, USA)
"Desynchronizing the Basal Ganglia Output Cells in the Substantia Nigra Pars Reticulate"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amJochen Roeper (Institute of Neurophysiology, Germany)
"Innate and Aquired Electrical Vulnerability of Dopamine Substantia Nigra Neurons"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmJoshua Berke (University of Michigan, USA)
"Is It Worth It? Dopamine Dynamics and the Value of Work"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmAusten Milnerwood (University of British Columbia, Canada)
"LRRK2 G2019S Knock-in Mice Have a Biphasic, Progressive Phenotype: Alterations to Dopamine and Glutamate Transmission/Tone, Early Hyperactivity and Later Cognitive Deficits"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCompensatory Synaptic Mechanisms
Discussion Leader: Un Kang (Columbia University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmAngela Cenci Nilsson (Lund University, Sweden)
"Steps in Dyskinesia"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmDavid Eidelberg (The Feinstein Institute for Medical Research, USA)
"Network Alterations"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmJun Ding (Stanford University School of Medicine, USA)
"Neurotransmitter Co-Release by Midbrain Dopamine Neurons"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmVatsala Jayasinghe (Chicago Medical School, Rosalind Franklin University of Medicine and Science, USA)
"Frequency-Dependent Corticostriatal Disinhibition Resulting from Chronic Dopamine Depletion: Role of Striatal cGMP and GABA-A R Signaling"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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