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Translation Machinery in Health and Disease
Gordon Research Conference

Protein Synthesis and Beyond

Dates

February 22-27, 2015

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chairs:
Xiang-Lei Yang & Jonathan Yewdell

Vice Chair:
Sunghoon Kim

Meeting Description

Alterations in the translation apparatus and defective translation results in myriad diseases and enables immunosurveillance. Mutations in genes for tRNAs, tRNA synthetases, tRNA modifying factors, initiation, elongation and release factors are linked to neurodegenerative diseases and/or type 2 diabetes; tRNA synthetase is one of the largest gene families associated with Charcot-Marie-Tooth disease; genes encoding ribosomal proteins are mutated in 50% of Diamond-Blackfan Anemia patients; autoantibodies against tRNA synthetases are the hallmark of a chronic autoimmune disorder-antisynthetase syndrome; tRNA, tRNA synthetases, translation factors and ribosomal proteins are associated with tumorigenesis; specific tRNAs and elongation factors are critical for HIV viral reverse transcription; and alterations in the translation apparatus are a central feature of viral infections.

This is the first disease-focused conference for the broad field of protein translation. The conference features an opening keynote session and 8 disease-focused sessions each led by a distinguished scientist from academia, clinical medicine, or the biopharmaceutical industry. Each disease session will focus on a specific disease area and blend translation and translation machinery-related basic science with dysregulations underlying various pathologies. The conference will cover many disease areas including cancer as well as neurological, immunological, infectious, hematological, vascular, metabolic, and mitochondrial diseases.

In addition to other prominent speakers, an exciting array of influential scientists including Nobel laureate Ada Yonath, US National Medal of Science laureate Stephen Benkovic, tRNA synthetase pioneer Paul Schimmel, translation rate-limiter eIF4E discoverer Nahum Sonenberg, and ribosome profiling pioneer Jonathan Weissman will give keynote lectures in the opening session and throughout the conference.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: New Frontiers in Translation
Discussion Leader: Xiang-Lei Yang (The Scripps Research Institute, USA)
7:40 pm - 8:10 pmKeynote: Paul Schimmel (The Scripps Research Institute, USA)
"The New Biology of Human tRNA Synthetases"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:30 pmSelected from Poster Abstracts: Yan Qin (Institute of Biophysics, CAS, China)
"A Mitochondrial Translation Quality Control Mechanism is Selectively Required for Male Fertility"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmSelected from Poster Abstracts: Andrey Karamyshev (University of Texas Southwestern Medical Center, Dallas, USA)
"Lost in Translation: Regulation of Aberrant Protein Production (RAPP) in Health and Disease"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKeynote: Stephen Benkovic (Pennsylvania State University, USA)
"Discovery and Development of Benzoxaboroles in Medicinal Chemistry"
9:20 pm - 9:30 pmDiscussion
Monday
8:30 amGroup Photo
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInfectious Diseases and Immunity
Discussion Leader: Jonathan Yewdell (National Institutes of Health, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:35 amKeynote: Ada Yonath (Weizmann Institute of Science, Israel)
"Ribosomes for Medicine"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amMichael Ibba (The Ohio State University, USA)
"Translation Quality Control Mediates Microbial Stress Responses"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amBabak Javid (Tsinghua University School of Medicine, China)
"Tuberculosis Antibiotic Tolerance Due to the Indirect Aminoacylation Pathway"
10:35 am - 10:45 amDiscussion
10:45 am - 11:05 amCoffee Break
11:05 am - 11:25 amRobin Fahraeus (INSERM, France)
"mRNA Translation Control Links Viral Immune Evasion with Cell Growth"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amJonathan Yewdell (National Institutes of Health, USA)
"Translating Immunology"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Partho Sarothi Ray (IISER, Kolkata, India)
"The RNA-Binding Protein HuR Acts as a “microRNA Sponge” to Bind miR-21 and Prevent Translation Repression of Pro-Inflammatory Tumor Suppressor Gene Programmed Cell Death 4"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Monika Wolkers (Sanquin Research, The Netherlands)
"Post-Transcriptional Regulation Precludes Aberrant Cytokine Production in Memory T Cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInflammatory Diseases
Discussion Leader: Melissa Ashlock (aTyr Pharma, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmKenneth Stuart (Seattle Biomedical Research Institute, USA)
"Aminoacyl tRNA Synthetases for Two Cellular Translation Systems and Their Potential as Enhanced Drug Targets"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmMin Guo (The Scripps Research Institute - Scripps Florida, USA)
"Noncanonical Function of Lysyl-tRNA Synthetase Regulates the Allergic Response in Mast Cells"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmIngrid Lundberg (Karolinska Institutet, Sweden)
"Anti-Jo-1 Antibodies- A Biomarker of a Distinct Subset of Inflammatory Myopathies"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmMelissa Ashlock (aTyr Pharma, USA)
"Seeing with New Eyes: Aminoacyl tRNA Synthetases as Modulators of Fundamental Pathways"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTumorigenesis
Discussion Leader: Sunghoon Kim (Seoul National University, South Korea)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amDavide Ruggero (University of California, San Francisco, USA)
"Translation Makes an Impact: Tailor-Made Protein Expression for Metabolism, Cancer and Disease"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amRobert Schneider (New York University School of Medicine, USA)
"Translating the Regulation of Protein Synthesis to the Clinic in Metastatic Breast Cancer"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amCoffee Break
10:30 am - 10:50 amKun-Liang Guan (University of California, San Diego, USA)
"mORC1 Regulation by Amino Acids"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amJamie Cate (University of California, Berkeley, USA)
"Human eIF3 Targets Cell Proliferation mRNAs for Translational Activation or Repression"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amSunghoon Kim (Seoul National University, South Korea)
"Aminoacyl-tRNA Synthetases as Dual Target for Cancer Metabolism and Signal Pathway"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Daniela Brina (National Institute of Molecular Genetics, Italy)
"Translational Control Orchestrates Transcription to Promote Metabolic Reprogramming"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Yohei Kirino (Thomas Jefferson University, USA)
"Sex Hormone-Dependent tRNA Halves Enhance Cell Proliferation in Breast and Prostate Cancers"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranslation Modulation and Metabolic Diseases
Discussion Leader: Lluis Ribas de Pouplana (IRB Barcelona, Spain)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmLluis Ribas de Pouplana (IRB Barcelona, Spain)
"A Mitochondrial Protein That Modulates Transcription, Translation, and Cell Cycle"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAnders Bystrom (University of Umea, Sweden)
"Transfer RNA Modification Defects and Familial Dysautonomia (FD) Disease"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRita Horvath (Institute of Genetic Medicine, United Kingdom)
"Deficient RNA Metabolism as a Novel Target in Neuromuscular Disease"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAkshay Vaishnaw (Alnylam Pharmaceuticals, USA)
"RNAi-Based Approaches for the Treatment of TTR Amyloidosis"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeurological Disorders
Discussion Leader: Susan Ackerman (Howard Hughes Medical Institute / The Jackson Laboratory, USA)
9:00 am - 9:30 amKeynote: Nahum Sonenberg (McGill University, Canada)
"Translational Control of Neurodevelopmental Disease"
9:30 am - 9:40 amDiscussion
9:40 am - 9:45 amIntroduction by Discussion Leader
9:45 am - 10:05 amAlbena Jordanova (University of Antwerp, Belgium)
"Unraveling the Role of Aminoacyl-tRNA Synthetases in Neurodegeneration: Come Fly With Us"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amSusan Ackerman (Howard Hughes Medical Institute / The Jackson Laboratory, USA)
"Ribosome Pausing and Neurodegeneration"
10:35 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:20 amEric Klann (New York University, USA)
"Dysregulated Translational Control in CNS Disorders"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJennifer Darnell (Rockefeller University, USA)
"Translational Control by Fragile X Mental Retardation Protein: Neuronal Targets and Mechanism"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Claudio Joazeiro (The Scripps Research Institute, USA)
"The E3 Ligase Listerin/Ltn1 Links Ribosome-Associated Protein Quality Control and Neurodegeneration"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Truus Abbink (Vrije University Medical Centre / CNCR, The Netherlands)
"Towards the Molecular Disease Mechanism of Vanishing White Matter"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmVascular and Hematologic Disorders
Discussion Leader: Paul Fox (Cleveland Clinic, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmTaisuke Kanaji (The Scripps Research Institute, USA)
"Megakaryocyte Development and Platelet Production: Novel Role of Tyrosyl-tRNA Synthetase"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmAlyson MacInnes (The Netherlands)
"When Ribosomal Proteins Go Wrong"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmSteven Ellis (University of Louisville, USA)
"Diamond Blackfan Anemia: Genotype/Phenotype Relationships"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmPaul Fox (Cleveland Clinic, USA)
"Translational Readthrough of VEGFA mRNA Generates Anti-Angiogenic VEGF-Ax"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStress-Induced Adaptive Translation / Translation Machinery as Therapeutic Targets
Discussion Leaders: Paul Anderson (Harvard Medical School, USA) and Susan Martinis (University of Illinois, Urbana-Champaign, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amPaul Anderson (Harvard Medical School, USA)
"Angiogenin, tRNA, and Amyotrophic Lateral Sclerosis"
9:25 am - 9:30 amDiscussion
9:30 am - 9:50 amTao Pan (The University of Chicago, USA)
"Methionine Mistranslation and Stress Response"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMyriam Gorospe (National Institute on Aging, USA)
"Translational Control in Cellular Senescence"
10:20 am - 10:30 amDiscussion
10:30 am - 10:55 amCoffee Break
10:55 am - 11:15 amRandal Kaufman (Sanford-Burnham Medical Research Institute, USA)
"Is Protein Misfolding in the Endoplasmic Reticulum Oncogenic?"
11:15 am - 11:25 amDiscussion
11:25 am - 11:30 amIntroduction by Discussion Leader
11:30 am - 11:40 amSelected from Poster Abstracts: Auinash Kalsotra (University of Illinois, USA)
"Poly(A) Binding Protein C1 Is Developmentally Regulated and Controls a Post-Transcriptional Pathway to Stimulate Cardiac Hypertrophy"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Gerald McInerney (Karolinska Institutet, Sweden)
"Viral and Cellular Proteins Containing FGDF Motifs Bind G3BP to Block Stress Granule Formation"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmKarin Musier-Forsyth (The Ohio State University, USA)
"Exploiting the Critical Role of tRNAs and Aminoacyl-tRNA Synthetases in Retroviral Replication for the Development of Novel HIV-1 Therapeutics"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranslation Machinery as Therapeutic Targets
Discussion Leader: Susan Martinis (University of Illinois, Urbana-Champaign, USA)
7:30 pm - 7:40 pmSelected from Poster Abstracts: Hanchao Zhao (University of Illinois at Urbana Champaign, USA)
"Trafficking of Leucyl-tRNA Synthetase in E. coli"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 8:05 pmAllan Jacobson (University of Massachusetts Medical School, USA)
"Ataluren-Mediated Therapeutic Nonsense Suppression"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:25 pmSelected from Poster Abstracts: Gwendolyn Gunn (University of Alabama at Birmingham, USA)
"Evaluation of Nonsense Suppression and NMD inhibition in Response to Investigational 'Read-Through' Compounds"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmSelected from Poster Abstracts: Norbert Polacek (University of Bern, Switzerland)
"The Ribosome as Novel Target for Stress-Induced Small Regulatory RNAs"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmKeynote: Jonathan Weissman (Howard Hughes Medical Institute / University of California, San Francisco, USA)
"Monitoring Translation in Space and Time Through Ribosome Profiling"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1 R13 AI 115770 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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