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Cartilage Biology & Pathology (GRS)
Gordon Research Seminar

Comprehending Cartilage Formation, Function and Failure for Improving Joint Health

Dates

April 1-2, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
Matthew R. McCann & Blandine Poulet

Meeting Description

The 2017 Gordon Research Seminar on Cartilage Biology and Pathology is a trainee organized and run conference for early investigators (graduate students, post-docs) to have the opportunity to present and discuss their research in an open and unintimidating style of meeting. The collegial atmosphere and opportunities for informal gatherings in the afternoons and evenings will promote brainstorming around fundamental cartilage knowledge as well as new and exciting avenues for future high impact research. This two-day seminar will highlight new and groundbreaking work done from young investigators around the world including Germany, England, France, Israel, China, Japan, Australia, Canada, United States and many others.

This meeting will focus on not only the understanding of cartilage formation and function that are critical for the development, mobility, and overall human health, but will also discuss potential therapeutic advances for cartilage maintenance and repair. Substantial advancements have been made in understanding human diseases that affect cartilage function such as osteoarthritis, rheumatoid arthritis and a growing number of genetic diseases of joints and cartilage. This meeting will help address these important morbidities, discuss the future of cartilage research and help establish long-term international collaborations to help cure joint disease.

Related Meeting

This GRS was held in conjunction with the "Cartilage Biology & Pathology" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: Genetic and Immunological Approaches to Cartilage and Extracellular Matrix Dysregulation
Discussion Leader: Matthew McCann (Columbia University, USA)
3:15 pm - 3:35 pmFarshid Guilak (Washington University in St. Louis, USA)
"Targeted Genome Engineering to Develop Cell-Based Vaccines for Arthritis"
3:35 pm - 3:45 pmDiscussion
3:45 pm - 3:55 pmMatthew Veras (Western University, Canada)
"Loss of ENT1 Alters Cell Cycle Processes in the Annulus Fibrosus of the Intervertebral Disc"
3:55 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmSkeletal and Cartilage Pathology
Discussion Leader: Farshid Guilak (Washington University in St. Louis, USA)
5:30 pm - 5:40 pmAnusha Ratneswaran (University of Western Ontario, Canada)
"Differences in Osteoarthritis Pathogenesis Between C57/B6 and CD1 Mice"
5:40 pm - 5:45 pmDiscussion
5:45 pm - 5:55 pmJason Klein (University of Washington, USA)
"Characterizing Genetic Risk Factors for Osteoarthritis Through CRISPR/Cas9-Mediated Saturation Genome Editing of the GDF5 5' UTR"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:10 pmAdrianne Stone (Baylor College of Medicine, USA)
"Combinatorial Gene Therapy of PRG4 and IL1Ra Is Protective of Cartilage Volume and Surface Area Compared to Monotherapy in a Murine Post-Traumatic Model of Osteoarthritis"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:25 pmMark Kim (University of Western Ontario, Canada)
"Characterization of the Mechano-Response of Annulus Fibrosus Cells to Cyclic Tensile Strain"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmShailesh Agarwal (University of Michigan, USA)
"Disruption of Neutrophil Extracellular Traps (NETs) Links Mechanical Strain to Post-Injury Inflammation, Pathologic Healing, and Ectopic Chondrogenesis"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 6:55 pmMarie Wehenkel (St. Jude Children's Research Hospital, USA)
"Investigating the Contributions of the Immune System to the Development of Cartilage Tumors"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmMateusz Aleksander Kudelko (The University of Hong Kong, Hong Kong SAR China)
"Proteomic Landscape of Murine Intervertebral Disc Reveals Mechanisms Involved in Homeostasis and Disc Structure Maintenance"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmAndreas Finnøy (Norwegian University of Science and Technology (NTNU), Norway)
"What Can We Learn About Articular Cartilage Postnatal Maturation Using Second-Harmonic Generation Microscopy?"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amKeynote Session: Stem-Cell Based Approaches for Cartilage Repair / Cartilage Development and Regeneration
Discussion Leader: Marina Feigenson (Harvard School of Dental Medicine, USA)
9:00 am - 9:20 amApril Craft (Boston Children's Hospital, USA)
"Cartilage from Embryonic Stem Cells: We All Gotta Start Somewhere"
9:20 am - 9:30 amDiscussion
9:30 am - 9:40 amSteven Woods (University of Manchester, United Kingdom)
"MATN3 V194D Mutant Human iPSCs Display Premature Hypertrophy and ER Stress During Chondrocyte Differentiation"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amCheng Wang (The University of Hong Kong, Hong Kong SAR China)
"Mechanistic Insights into ER Stress Induced Skeletal Defects Identify Therapeutic Opportunities"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amBeth Gibson (University of Newcastle, United Kingdom)
"The Disease Mechanisms of Skeletal Dysplasia Caused by Two Novel Aggrecan Mutations"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amManuela Rodrigues (University of Sao Paulo, Brazil)
"Thyroid Hormone Locally Interacts with the Sympathetic Nervous System to Control Bone Linear Growth"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amEran Assaraf (Weizmann Institute of Science, Israel)
"The Role of Proprioception and Specific Muscle Activity Patterns in Hip Joint Development and Maturation"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amShiri Kult (Weizmann Institute of Science, Israel)
"Tendon-to-Bone Attachment Unit – Two Faced Tissue"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmCell Metabolism and Regulation
Discussion Leader: Blandine Poulet (University of Liverpool, United Kingdom)
1:30 pm - 1:40 pmMargaret Man-Ger Sun (University of Western Ontario, Canada)
"Investigating the Role of the Retinoid X Receptor in Cartilage Development and Homeostasis"
1:40 pm - 1:45 pmDiscussion
1:45 pm - 1:55 pmJames Anderson (University of Liverpool, United Kingdom)
"Equine Synovial Fluid Metabolite Profiles in Septic and Non-Septic Joint Pathologies"
1:55 pm - 2:00 pmDiscussion
2:00 pm - 2:10 pmQing Yao (University of Michigan, USA)
"In Vivo Impairment of Mitochondrial Respiration Is an Indispensable Requirement for Survival of Hypoxic Cells"
2:10 pm - 2:15 pmDiscussion
2:15 pm - 2:25 pmJulia Etich (University of Cologne, Germany)
"MicroRNAs: Posttranscriptional Modulators of Cellular and Extracellular Cartilage Compartments"
2:25 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Funding for this conference was made possible by 1 R13 AR071265-01 from the National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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