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Multi-Drug Efflux Systems (GRS)
Gordon Research Seminar

Linking Molecular Mechanisms to Biological Functions of Transporters Through Innovation and Multidisciplinary Approaches

Dates

March 25-26, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Yu Toyoda & Karl A. Hassan

Meeting Description

The Gordon Research Seminar on Multidrug Efflux Systems is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The 2017 GRS on Multidrug Efflux Systems will offer excellent opportunities for young scientists to communicate with world-leading academic and industry scientists in an informal setting. The meeting aims to create an environment of innovation, where young scientists studying multidrug efflux systems from different perspectives or using different approaches are able to share their ideas and establish collaborative networks that will last into the future.

Topics covered by an interdisciplinary selection of speakers will include:

  • Biochemical studies of efflux pumps
  • Physiological importance and clinical relevance
  • Omics approaches for studying efflux pumps
  • Applications to drug discovery: inhibitors, screening systems and in silico approaches

To complement the program, the meeting will also include a mentoring session centered around a career development panel that will bring career perspectives from academia and industry.

This GRS will encourage young scientists to actively participate in the following Gordon Research Conference on Multidrug Efflux Systems, which will be held from March 26-31.

Related Meeting

This GRS was held in conjunction with the "Multi-Drug Efflux Systems" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Clinical Significance / Pharmacological Impact
Discussion Leader: Yu Toyoda (The University of Tokyo Hospital, Japan)
3:45 pm - 4:05 pmSusan Bates (Columbia University, USA)
"Clinical Significance of Multidrug Efflux Pumps: From Biology to Cancer Therapies"
4:05 pm - 4:10 pmDiscussion
4:10 pm - 4:25 pmNeha Agrawal (Purdue University, USA)
"Targeting HIV Reservoirs in Brain by Inhibition of P-Glycoprotein at the Blood-Brain Barrier"
4:25 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmApplication to Drug Discovery
Discussion Leaders: Toshihisa Ishikawa (NGO Personalized Medicine and Healthcare, Japan) and Olga Lomovskaya (The Medicines Company, USA)
7:30 pm - 7:45 pmMavis Jiarong Li (University of Washington, USA)
"Biophysical Characterizations of Drug Binding Coupled to ATP Hydrolysis by P-Glycoprotein Reconstituted in Lipid Nanodiscs"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmAnna Maria Barbuti (St. John's University, USA)
"Combination Therapy to Overcome ABC Transport Mediated Chemoresistance in a Colorectal Cancer Mouse Xenograft Model"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmAllison Lange (Purdue University, USA)
"Overcoming P-Glycoprotein-Associated Resistance in Chronic Myelogenous Leukemia with Dasatinib-Based Prodrugs"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmMohamed Saeed (Johannes Gutenberg University of Mainz, Germany)
"Activity of the Dietary Flavonoid, Apigenin, Against Multidrug-Resistant Tumor Cells as Determined by Pharmacogenomics and Molecular Docking"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMarine Schnetterle (French Armed Biomedical Research Institute (IRBA) / UMR-MD1, Aix Marseille Université, France)
"Phenothiazines Against Antibiotic Resistance: Impact on Efflux Pumps Expression of B. pseudomallei"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmErika Boulant (UMR-MD1, Aix Marseille Universite, France)
"Efflux Pumps as Tools to Increase Biofuel Tolerance in Bacteria"
9:25 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amKeynote Session: Biochemical Studies / Omics Approaches
Discussion Leaders: William Shafer (Emory University School of Medicine, USA) and Caroline Lee (National University of Singapore, Singapore)
9:00 am - 9:20 amHendrik van Veen (University of Cambridge, United Kingdom)
"Deciphering the Molecular Details of Substrate Transport and Energy Coupling in Bacterial Multidrug Efflux Pumps"
9:20 am - 9:25 amDiscussion
9:25 am - 9:40 amArthur Neuberger (University of Cambridge, United Kingdom)
"Hoechst 33342 Is a Hidden 'Janus' Amongst Substrates for the Multidrug Efflux Pump LmrP"
9:40 am - 9:45 amDiscussion
9:45 am - 10:00 amJennifer Reimche (Emory University School of Medicine, USA)
"Transcriptional Activation of Genes Encoding the MacAB Macrolide Efflux Pump by MisR in Neisseria gonorrhoeae"
10:00 am - 10:05 amDiscussion
10:05 am - 10:20 amPaulo Juarez (University of Franche-Comté, France)
"Carbonyl Stress Induces the Efflux System MexEF-OprN in Pseudomonas aeruginosa via a Novel Transcriptional Regulator, CmrA"
10:20 am - 10:25 amDiscussion
10:25 am - 10:40 amOnat Kadioglu (Johannes Gutenberg University of Mainz, Germany)
"Genomic and Transcriptomic Profiling of Resistant CEM/ADR-5000 and Sensitive CCRF-CEM Leukaemia Cells for Unravelling the Full Complexity of Multi-Factorial Multidrug Resistance"
10:40 am - 10:45 amDiscussion
10:45 am - 11:00 amGeneral Discussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Career Development Panel
Discussion Leader: Karl Hassan (University of Leeds, United Kingdom)
1:30 pm - 2:30 pmPanel Discussion
"Career Development Panel"
  • Toshihisa Ishikawa (NGO Personalized Medicine and Healthcare, Japan)
  • Caroline Lee (National University of Singapore, Singapore)
  • Olga Lomovskaya (The Medicines Company, USA)
  • William Shafer (Emory University School of Medicine, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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