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Stem Cells & Cancer (GRS)
Gordon Research Seminar

Signals Driving Proliferation, Differentiation, and Self-Renewal in Normal Tissues, Aging, and Cancer

Dates

February 11-12, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
Jeevisha Bajaj & Seerat Bajwa

Meeting Description

The Gordon Research Seminar on Stem Cells and Cancer is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

Mechanisms that drive normal development and regeneration are often deregulated in cancer. Thus, an understanding of signals that regulate stem cell self-renewal and differentiation has clear implications on malignant growth. In this meeting, we will explore genetic, epigenetic, molecular and cellular mechanisms that regulate the growth of normal and malignant stem cells. We will also explore novel approaches to targeting cancer progression and metastasis, such as immunotherapy and inhibiting cancer-niche interactions.

Related Meeting

This GRS was held in conjunction with the "Stem Cells & Cancer" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
1:30 pm - 4:30 pmArrival and Check-in
3:00 pm - 3:15 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:15 pm - 4:00 pmKeynote Session: Stem Cells in Cancer Initiation and Relapse
Discussion Leader: Yejing Ge (Rockefeller University, USA)
3:15 pm - 3:50 pmCedric Blanpain (Universite Libre de Bruxelles, Belgium)
"Stem Cells in Cancer Initiation and Relapse"
3:50 pm - 4:00 pmDiscussion
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmInvestigating Signals Driving Normal and Malignant Growth
Discussion Leader: Toni Celia-Terrasa (Princeton University, USA)
5:30 pm - 5:40 pmReyhan Akhtar (Monash University, Australia)
"SNAI1 Expression Correlates with Intestinal Stem Cell Markers in Colorectal Cancer"
5:40 pm - 5:45 pmDiscussion
5:45 pm - 5:55 pmLyndsay Murrow (University of California, San Francisco, USA)
"Reconstituting the Mammary Stem Cell Niche"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:10 pmZhiyang Chen (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
"Cohesin Deficiency-Induced Differentiation Defect Contributes to Clonal Expansion in Hematopoietic Stem Cells During Aging"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:25 pmSejal Vyas (Harvard Medical School, USA)
"SIRT4 Regulation of Intestinal Homeostasis upon DNA Damage"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmNikki Lytle (University of California, San Diego, USA)
"Stem Cell Signals Drive Pancreatic Cancer Therapy Resistance"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 6:55 pmSimon Schworer (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
"Epigenetic Stress Responses Induce Muscle Stem-Cell Aging by Hoxa9 Developmental Signal"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmTheodore Ho (University of California, San Francisco, USA)
"Autophagy Maintains the Metabolism and Function of Young and Old Hematopoietic Stem Cells"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmGeorg Sedlmeier (Centre for Biomedicine and Medical Technology Mannheim (CBTM), University of Heidelberg, Germany)
"Matrix-Assisted Autocrine BMP Signalling Regulates Stemness Properties in Melanoma Cells Through Induction of Id1 and Id3 Expression"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amCancer Stem Cell Biology
Discussion Leader: Mark Esposito (Princeton University, USA)
9:00 am - 9:10 amToni Celia-Terrasa (Princeton University, USA)
"The miR-199a Pathway Mediates the Evasion of Normal and Cancer Stem Cells from Interferon-Imposed Constraint"
9:10 am - 9:15 amDiscussion
9:15 am - 9:25 amJessie Brown (New York University School of Medicine, USA)
"Defining Cellular Quiescence as a Multi-Drug Resistance Mechanism in Squamous Cell Carcinoma"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amYejing Ge (Rockefeller University, USA)
"At the Crossroads of Wound-Repair and Cancer"
9:40 am - 9:45 amDiscussion
9:45 am - 9:55 amKihyun Lee (Memorial Sloan Kettering Cancer Center, USA)
"Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development"
9:55 am - 10:00 amDiscussion
10:00 am - 10:10 amScott Callahan (Memorial Sloan Kettering Cancer Center, USA)
"Cell of Origin Studies of Malignant Melanoma Using both Transgenic Zebrafish and Human Pluripotent Stem Cell-Derived Melanocytes"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amKyle Spinler (University of California, San Diego, USA)
"Identifying Elements of the Msi2 Network Provides a New Therapeutic Window into Controlling Blast Crisis Chronic Myelogenous Leukemia"
10:25 am - 10:30 amDiscussion
10:30 am - 10:40 amAlastair Davies (University of British Columbia, Canada)
"EZH2 Reprogramming Confers Intrinsic Stem Cell Properties and Developmental Plasticity Driving Neuroendocrine Prostate Cancer"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amMithil Soni (University of South Carolina, USA)
"Multifaceted microRNA-489 Inhibits Autophagy and Cancer Stem Cell Population in Breast Cancer and Sensitizes Breast Cancer Cells to Doxorubicin"
10:55 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: Exploring Diverse Career Options Post-Training
Discussion Leader: Lyndsay Murrow (University of California, San Francisco, USA)
1:30 pm - 2:30 pmPanel Discussion
"Career Options Post-Training"
  • Cedric Blanpain (Universite Libre de Bruxelles, Belgium)
  • Lenhard Rudolph (Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Germany)
  • Amy Wagers (Harvard University, USA)
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R13CA213446. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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