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Alcohol-Induced End Organ Diseases
Gordon Research Conference

Metabolic Reprogramming and Molecular Mechanisms of Tissue Injury by Alcohol

Dates

March 26-31, 2017

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chairs:
Bin Gao & Andras Orosz

Vice Chair:
Laura E. Nagy

Meeting Description

The 2017 Gordon Research Conference (GRC) on Alcohol-Induced End Organ Diseases "Metabolic Reprogramming and Molecular Mechanisms of Tissue Injury by Alcohol" will provide a unique forum to bring together a diverse range of young and established scientists who are studying alcohol-related organ damage. This newly approved Gordon Research Conference exclusively addresses alcohol-induced end organ disorders and will cover a broad range of studies at the molecular, cellular, systems, and organismal level, with particular emphasis on multidisciplinary work and innovative approaches. This GRC conference will 1) provide an international forum that promotes open discussion of cutting edge research at the forefront of alcohol-induced tissue injury, 2) foster the development of the next generation of investigators to study alcohol-induced organ damage, 3) promote interaction between young and senior investigators, 4) facilitate the exchange of ideas that will shape the future directions of the alcohol and tissue injury community, and 5) introduce breakthrough techniques that facilitate the understanding of mechanisms driving alcohol-induced tissue injury. This GRC conference will significantly advance current understanding of the underlying mechanisms of end organ injury and stimulate development of effective therapeutic strategies for the diagnosis, prevention and treatment of alcohol-related disorder. Talks will address questions centered on the basic mechanisms that contribute to alcohol-induced organ damage across the entire lifespan and will include wide ranging experimental systems from microbiome to humans. The format will provide ample time for formal and informal discussions and emphasize the presentation of unpublished data, thus ensuring that the newest and most exciting developments in the field are discussed. Poster sessions will take place on each day of the meeting, allowing for widespread participation of conference attendees at all career stages. Speakers will also be selected from submitted abstracts for "late-breaking topic" talks by young investigators. Participation by young investigators will be strongly encouraged.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Novel Mechanisms of Multiple-Organ and Tissue Injury
Discussion Leader: Jan Hoek (Thomas Jefferson University, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:25 pmBernd Schnabl (University of California, San Diego, USA)
"Host-Microbiome Interactions in Alcohol-Associated Diseases"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmGyongyi Szabo (University of Massachusetts Medical School, USA)
"Triggers, Pathways and Mediators of Alcohol-Induced Tissue Inflammation"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProteostasis (Protein Homeostasis) in Alcohol-Induced Organ Injury
Discussion Leader: Neil Kaplowitz (University of Southern California, USA)
9:00 am - 9:20 amWen-Xing Ding (University of Kansas Medical Center, USA)
"Autophagy, a Common Mechanism for Alcohol-Induced Liver and Pancreatic Injury"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amStephen Pandol (Cedars-Sinai Medical Center, USA)
"Regulation of Endoplasmic Reticulum Protein Processing with Alcohol"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSelected from Poster Abstracts: William Balch (The Scripps Research Institute, USA)
"Precision Monitoring of Alcohol in Health and Disease"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Shengmin Yan (Indiana University School of Medicine, USA)
"Establishment of a Cellular Model to Study Ethanol-Induced Lipophagy"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amPranoti Mandrekar (University of Massachusetts Medical School, USA)
"Targeting Proteostasis Pathways: New Therapeutic Paradigm in Alcoholic Liver Disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amSrinivasan Dasarathy (Cleveland Clinic, USA)
"Mechanism of Skeletal Muscle Proteostasis and Sarcopenia in Alcoholic Liver Disease"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Mengwei Zang (University of Texas Health Science Center at San Antonio, USA)
"Activation of mTORC1 Contributes to the Development of Alcoholic Liver Injury in Mice"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Hyo-Jung Kwon (College of Veterinary Medicine, Chungnam National University, South Korea)
"Vitamin D3 Upregulated Protein 1-Depdendant Autophagy and Fatty Acid Oxidation Attenuates Liver Steatosis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Kovacs (University of Colorado Denver, USA) and Pranoti Mandrekar (University of Massachusetts Medical School, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAlcohol, Stem Cells, and Cancer
Discussion Leader: Helmut Seitz (University of Heidelberg, Germany)
7:30 pm - 7:50 pmLorraine Gudas (Weill Cornell Medicine, USA)
"The Effects of Alcohol on Epithelial Stem Cells of the Oral Cavity and Esophagus During Carcinogenesis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmVasilis Vasiliou (Yale School of Public Health, USA)
"Aldehyde Dehydrogenases in Cancer Stem Cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmKeigo Machida (Keck School of Medicine, University of Southern California, USA)
"Cell Fate Decision and Metabolic Reprograming of Tumor-Initiating Stem-Like Cells in Alcohol-Associated Injury and Cancer"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Chin-Yo Lin (University of Houston, USA)
"Alcohol Modulates Hormonal and Oncogenic Signaling in Breast Cancer Cells"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Prasanna Chandramouleeswaran (The University of Pennsylvania, USA)
"Alcohol Promotes Esophageal Tumor Growth by Enriching Cancer Stem Cells with a High Autophagy Capacity"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmunologic Mechanisms
Discussion Leader: Gavin Arteel (University of Louisville, USA)
9:00 am - 9:20 amCynthia Ju (University of Colorado Health Science Center, USA)
"IL-1 Receptor Like 1 (ST2) Protects Against Alcoholic Liver Injury and Inflammation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amHidekazu Tsukamoto (University of Southern California, USA)
"Caspase 11-Gasdermin-D Pathway in Alcoholic Hepatitis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSelected from Poster Abstracts: Thomas McIntyre (Cleveland Clinic, USA)
"Molecular Mechanisms of Alcoholic Kidney Disease: Role of Neutrophils"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Kyle Poulsen (Cleveland Clinic, USA)
"MIF Inhibition Protects Hepatocytes from Ethanol-Induced Injury Independent of Neutrophil Accumulation"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amFlavia Souza-Smith (LSU Health Sciences Center New Orleans, USA)
"Mesenteric Lymphatic/Perilymphatic Adipose Tissue Crosstalk: Mechanism of Alcohol Immunomodulation"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amElizabeth Kovacs (University of Colorado Denver, USA)
"Alcohol Intoxication and the Pulmonary Inflammatory Response After Injury"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Yingzi Yang (Harvard School of Dental Medicine, USA)
"Hippo Signaling in Alcohol-Induced Multiple Organ Injury and Inflammation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Puneet Puri (Virginia Commonwealth University, USA)
"Circulating Microbiome Changes Are Associated with the Development and Severity of Alcoholic Hepatitis"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNon-Coding RNA and Extracellular Vesicles
Discussion Leader: David Brigstock (Nationwide Children's Hospital, USA)
7:30 pm - 7:50 pmVijay Shah (Mayo Clinic, USA)
"Extracellular Vesicles and Alcoholic Liver Disease"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmLi Wang (University of Connecticut, USA)
"Non-Coding RNA as Novel Regulator of Alcoholic Fatty Liver"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmWon-IL Jeong (KAIST, South Korea)
"Exosomes and TLR3 in Liver Fibrosis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Kelly McDaniel (Baylor Scott and White Health, USA)
"The Let7/Lin28 Axis Regulates Activation of Hepatic Stellate Cells in Alcoholic Liver Injury"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Ming-Jiang Xu (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"ER Stress-Dependent Release of Mitochondrial DNA Enriched Microparticles Contributes to Acute-on-Chronic Alcoholic Neutrophilia and Hepatotoxicity"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAlcohol, Gut Microbiota, Intestinal Barrier Function, and Fat Metabolism
Discussion Leader: Carol Casey (University of Nebraska, USA)
9:00 am - 9:20 amCraig McClain (University of Louisville, USA)
"Alcohol:Fat Interactions in the Development/Treatment of Alcoholic Liver Disease"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMin You (Northeast Ohio Medical University, USA)
"Adiponectin-FGF15/19 Signaling, a Pivotal Adipose-Gut-Liver Axis in Alcoholic Steatohepatitis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSelected from Poster Abstracts: Richard Parker (University of Birmingham, United Kingdom)
"The Impact of Adiosity on Alcoholic Hepatitis: Just Enough Fat Is Good for You"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Rotonya Carr (University of Pennsylvania, USA)
"Absence of Perilipin 2 Prevents the Increase of Long-Chain Ceramides in the Lipid Droplet Fractions of Alcohol-Fed Mice"
10:25 am - 10:30 amDiscussion
10:30 am - 10:45 amCoffee Break
10:45 am - 11:05 amAli Keshavarzian (Rush University Medical Center, USA)
"Microbiota, Gut Leakiness to Endotoxins and Circadian Disruption in Alcohol Use Disorders"
11:05 am - 11:15 amDiscussion
11:15 am - 11:35 amPatricia Molina (Louisiana State University, USA)
"Alcohol-SIV/HIV-ART Interactions Promote Metabolic Dysregulation"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Robert Helsley (Cleveland Clinic Foundation, USA)
"Targeting the Gut Microbial TMA-Lyase for the Treatment of Alcohol-Induced Liver Injury"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Tasha Barr (University of California, Riverside, USA)
"Impact of Chronic Ethanol Consumption on Pathophysiology and Mucosal Gene Expression of the Gastrointerestinal Tract in Rhesus Macaques"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmGeorge Koob (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Alcohol-Induced Organ Injury: Current and Future NIAAA Priorities"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMitochondria in Alcohol-Induced Organ Damage
Discussion Leader: John Lemasters (Medical University of South Carolina, USA)
7:30 pm - 7:50 pmGyorgy Hajnoczky (Thomas Jefferson University, USA)
"Targeting of Mitochondrial Dynamics and Survival Mechanisms by Alcohol in Heart and Liver"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmShannon Bailey (University of Alabama at Birmingham, USA)
"Role of the Circadian Clock in Alcohol-Induced Alterations in Hepatic Mitochondrial Energy Metabolism"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmNarayan Avadhani (University of Pennsylvania, USA)
"Mitochondria-Targeted Cyp2E1 Modulates Alcohol Liver Toxicity"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Elizabeth Bartolak-Suki (Boston University, USA)
"Beneficial and Harmful Level of Alcohol Interact with Mechanical Stretch Pattern on Mitochondrial Function in Vascular Smooth Muscle Cells"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Hongkyun Kim (Rosalind Franklin University of Medicine and Science, USA)
"Alcohol-Induced Muscle Damage in C. elegans"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPreclinical/Translational Approaches and Treatment in Alcohol-Associated Diseases
Discussion Leader: Mack Mitchell (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:20 amPhilippe Mathurin (Centre Hospitalier Universitaire de Lille, France)
"Therapeutic Strategy in Severe Alcoholic Hepatitis: From Present to Future Development of New Molecules"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRamon Bataller (University of North Carolina at Chapel Hill, USA)
"Novel Therapeutic Targets for Alcoholic Hepatitis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSelected from Poster Abstracts: Devanshi Seth (Centenary Institute, Royal Prince Alfred Hospital, Australia)
"Performance of Liver Function Tests in the GenomALC Chohor for Alcohol Consumption: New Gender Cutoffs in Alcoholics with Liver Cirrhosis"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Ashwani Singal (University of Alabama at Birmingham, USA)
"Cellular Biogenergetics: Personalizing Treatment in Alcoholic Liver Disease"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amGeorge Kunos (National Institutes of Health, USA)
"Multitarget Approach for the Pharmacotherapy of Liver Fibrosis"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amShelly Lu (Cedars-Sinai Medical Center, USA)
"Role of SAMe in Liver Injury and Cancer"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmUrszula Iwaniec (Center for Healthy Aging Research, Oregon State University, USA)
"Alcohol: A Simple Nutrient with Complex Actions on Bone in the Adult Skeleton"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPost-Metabolic Signaling and Stress Pathways
Discussion Leader: Charles Lang (Penn State College of Medicine, USA)
7:30 pm - 7:50 pmPal Pacher (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Deleterious Effects of Binge Drinking on Chronic Ethanol Feeding-Induced Metabolic Dysregulation and Cardiovascular Dysfunction in Mice"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJason Gardner (LSU Health Sciences Center New Orleans, USA)
"Alcohol and The Heart: Interference of Compensatory Remodeling"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDaria Mochly-Rosen (Stanford University School of Medicine, USA)
"Ethanol and Precision Medicine: New Considerations for an Old Problem"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Mariann Piano (University of Illinois at Chicago College of Nursing, USA)
"MicroRNA21 Inhibtion Restores Binge Drinking Impaired Microvascular Function in Young Adults"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Manikandan Panchatcharam (LSU Health Sciences Center Shreveport, USA)
"Alcohol-Induced LPP3 Suppression Leads to Blood-Brain Barrier Dysfunction"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

This meeting is supported by AASLD.

Research reported in this publication was supported by the National Institute On Alcohol Abuse And Alcoholism of the National Institutes of Health under Award Number 1 U13 AA025249-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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