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Neuroimmune Communication in Health & Disease
Gordon Research Conference

Neuro-Immune Interactions During Homeostasis and Neurological Disorders

Dates

January 15-20, 2017

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chairs:
Dorian McGavern & Zsuzsanna Fabry

Vice Chair:
Jonathan Kipnis

Meeting Description

The field of neuroimmunology has evolved considerably over the past two decades and emerged into one of the fastest moving disciplines in biomedical research. Neuroimmunology has roots in the study of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis, but has broadened to include research focused on how the CNS and immune system communicate during various states of health and disease. The neural-immune interface is remarkably sophisticated, and recent studies have shown that the immune system actively participates in the development and maintenance of the CNS. These two systems have a continual dialogue throughout life that can either be beneficial or detrimental to human health. The benefits of CNS-immune interactions include synaptic pruning, maintenance of barriers, compartmentalization and cleanup of damaged tissue, clearance of infectious agents, etc. By contrast, the immune system can also directly damage the CNS by participating in autoimmune reactions, vascular breakdown, and neurodegeneration. It is therefore incredibly important to understand and discuss the mechanisms that give rise to these divergent outcomes.

The field of neuroimmunology is in a phase of rapid growth, and it is our intention to capture this momentum with a new meeting focused on neuro-immune communication. The meeting will reflect the breadth of the field by hosting speakers and attendees with an interest in understanding neuro-immune interactions that maintain a healthy CNS during development and in adulthood as well as ones that participate in different pathophysiological conditions, such as autoimmune disease, stroke, neurodegenerative disorders, infection, brain / spinal cord injury, etc. We also intend to showcase burgeoning areas of neuro-immune research like the influence of the microbiome on CNS immune function as well as how peripheral nerves directly modulate immune cells. Our aim is to attract the top researchers in the field and promote dynamic discussions as well as a sustainable forum for members of the community to interact in the future. Please join us in Ventura, CA for what should be an exciting inaugural meeting on this important contemporary topic.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Lessons Learned from Multiple Sclerosis
Discussion Leader: Hartmut Wekerle (Max Planck Institute of Psychiatry, Germany)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:05 pmVanja Lazarevic (National Institutes of Health, USA)
"T-bet+ NKp46+ Innate Lymphocytes Are Critical for TH17 Mediated Neuroinflammation"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmClaudia Lucchinetti (Mayo Clinic, USA)
"Pathogenic and Clinical Implications of MS Immunopathological Heterogeneity"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmLawrence Steinman (Stanford University, USA)
"Personal Insights into Neuroimmune Communication in Health and Disease Spanning 40 Years"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMicroglia Functions During Homeostasis and Neurological Diseases
Discussion Leader: Ari Waisman (University of Mainz, Germany)
9:00 am - 9:20 amCarla Shatz (Stanford University, USA)
"Surprise at the Synapse: MHC I, Pruning, and Circuit Tuning"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMarco Prinz (University of Freiburg, Germany)
"Origin and Function of CNS Macrophages"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amCelia Shiau (University of North Carolina at Chapel Hill, USA)
"Induction of Immunoresponsive Gene Irg1 Enables In Vivo Reporting of Microglia Activation and Its Regulation in Zebrafish"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amHugo Peluffo (Institut Pasteur de Montevideo, France / University of the Republic, Uruguay)
"CD300f Immunoreceptor Deficiency Induced Depressive and Obsessive Compulsive Behaviours and Exacerbation of Microglial Activation After Diverse Inflammatory Stimuli"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amBeth Stevens (Boston Children's Hospital, USA)
"How Microglia Prune Specific Synapses"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMarco Colonna (Washington University School of Medicine in St. Louis, USA)
"TREM2 in Microglia Homeostasis and Neurodegeneration"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSusanna Rosi (University of California, San Francisco, USA)
"Trauma-Induced Infiltrating Monocytes Proliferate After Entry in the Brain"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMatthew Russo (National Institutes of Health, USA)
"Distinct Myeloid Cell Subsets Promote Angiogenesis and Damaged Tissue Clearance Following Mild Traumatic Brain Injury"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Zsuzsanna Fabry (University of Wisconsin-Madison, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMicrobiome-Brain Communication
Discussion Leader: Emeran Mayer (University of California, Los Angeles, USA)
7:30 pm - 7:50 pmRachel Caspi (National Eye Institute, NIH, USA)
"Microbiota and the Eye"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJosef Anrather (Weill Cornell Medicine, USA)
"The Immunology of the Microbiota-Gut-Brain Axis in Stroke"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAlban Gaultier (University of Virginia, USA)
"Eat Good, Feel Good - The Link Between the Microbiome and Depression"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAsya Rolls (Technion - Israel Institute of Technology, Israel)
"Brain-Regulated Immunity: Specific Brain Circuits that Can Alter the Immune Response to Bacteria and Tumors"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmImmune Effects on Brain Function
Discussion Leader: Lisa Boulanger (Princeton University, USA)
9:00 am - 9:20 amRobin Franklin (University of Cambridge, United Kingdom)
"The Innate Immune System and the Regeneration of CNS Myelin"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amFrauke Zipp (Research Center Immunology (FZI), Rhine Main Neuroscience Network, Germany)
"Counterbalancing Inflammatory Processes Within the Brain"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amJuan Garre (New York University School of Medicine, USA)
"CX3CR1+ Monocytes Alter Learning and Learning-Dependent Dendritic Spine Plasticity During Viral Immune Activation"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amAntoine Louveau (University of Virginia, USA)
"Meningeal Lymphatic Vessels Regulate CNS Immune Surveillance and Autoimmune Attacks"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMichal Schwartz (Weizmann Institute of Science, Israel)
"The Immune System Shapes the Brain Through Its Borders: Rejuvenation by Immune Checkpoint Blockade for Fighting Alzheimer's Disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amJudy Van de Water (University of California, Davis, USA)
"Maternal Immune Factors in ASD: Thinking Outside the Brain"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJun Huh (University of Massachusetts Medical School, USA)
"Maternal Factors Promoting IL-17a Dependent Autism-Like Phenotypes in Offspring"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAnna Molofsky (University of California, San Francisco, USA)
"Astrocyte-Microglial Cross-Talk Regulates Synaptic Pruning During Brain Development"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImmunity and Neurodegeneration
Discussion Leader: Costantino Iadecola (Weill Cornell Medicine, USA)
7:30 pm - 7:50 pmTika Benveniste (University of Alabama at Birmingham, USA)
"The Role of Protein Kinase CK2 in Neuroinflammation"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDritan Agalliu (Columbia University Medical Center, USA)
"The Role of Immune Cells in Movement and Neuropsychiatric Disorders - Lessons from Animal Models"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmFrank Heppner (Charité - Universitätsmedizin Berlin, Germany)
"Microglial Actions in Alzheimer's Disease"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmSamuel David (Research Institute of the McGill University Health Centre, Canada)
"Cross-Talk Between Microglia and Peripheral Macrophages in Spinal Cord Injury"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDAMPs, PAMPs, and Alarmins that Regulate Immunity in the CNS
Discussion Leader: Monica Carson (University of California, Riverside, USA)
9:00 am - 9:20 amMelissa Brown (Feinberg School of Medicine, Northwestern University, USA)
"IL-33 Regulation of Sex-Dimorphic EAE"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKaterina Akassoglou (Gladstone Institutes / University of California, San Francisco, USA)
"Fibrinogen in Neurological Diseases"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amArthur Vandenbark (Oregon Health and Science University / VA Portland Health Care System, USA)
"A New Model of MIF/CD74 Binding Interactions"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amAileen Anderson (University of California, Irvine, USA)
"Stem Cells and the Inflammatory Microenvironment"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amJenny Ting (University of North Carolina at Chapel Hill, USA)
"Intracellular Innate Immune Receptors: Roles in Neuroinflammation and Beyond"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKodi S. Ravichandran (University of Virginia, USA)
"Eating a Good Apoptotic Meal: Lessons from Phagocytes"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmRoosmarijn Vandenbroucke (VIB, Ghent University, Belgium)
"The Blood-Cerebrospinal Fluid Barrier Plays an Important Role in Neuroinflammation: Implications for Novel Therapeutic Strategies"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmNorifumi Iijima (National Institute of Biomedical Innovation, Japan)
"Access of Protective Antiviral Antibody to Neuronal Tissues Requires CD4 T-Cell Help"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmPNS-Immune Interactions
Discussion Leader: Nader Ghasemlou (Queen's University, Canada)
7:30 pm - 7:50 pmElaine Hsiao (University of California, Los Angeles, USA)
"Neurochemical Signaling Between the Gut Microbiota and Nervous System"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmIssac Chiu (Harvard Medical School, USA)
"The Role of Nociceptive Sensory Neurons in Bacterial Detection and Host Defense"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPaul Sawchenko (Salk Institute for Biological Studies, USA)
"Immune-to-Brain Signaling for Control of the Stress Axis: A Portal for Intervening in Neurological Disorders?"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmKevin Tracey (Feinstein Institute for Medical Research, USA)
"Understanding Reflex Circuit Mechanisms in Immunity"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmune Signaling in the CNS
Discussion Leader: Zsuzsanna Fabry (University of Wisconsin-Madison, USA)
9:00 am - 9:20 amFlorent Ginhoux (Singapore Immunology Network, Singapore)
"Ontogeny and Differentiation of Microglial Cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDongsheng Cai (Albert Einstein College of Medicine, USA)
"Hypothalamic Inflammation in Metabolic Diseases and Aging"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amIftach Shaked (University of California, San Diego, USA)
"The Sympathetic Side of Phagocytes: From Autoimmunity to Stroke"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amFederica La Russa (King's College London, United Kingdom)
"Disruption of Neuronal Signalling Impairs Resolution of Cutaneous Inflammation"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amFrancisco Quintana (Brigham and Women's Hospital, USA)
"Regulation of Inflammation by Astrocytes"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amAlexandre Prat (Centre Hospitalier de l'Universite de Montreal, Canada)
"What About Roles of the BBB in Neuroinflammation"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJorge Alvarez (University of Pennsylvania, USA)
"The Blood Meningeal Barrier Orchestrates the Development of Neuroinflammatory Responses"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMatthew Schindler (National Institutes of Health, USA)
"Severe, Episodic Neuroinflammation Due to Cytotoxic T-Lymphocyte Antigen-4 (CTLA4) Haploinsufficiency"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImpact of Infectious Immunity on CNS Function
Discussion Leader: Charles Howe (Mayo Clinic, USA)
7:30 pm - 7:50 pmKarin Peterson (Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, USA)
"Innate Immune Responses to Viral Infections in the Brain: Dr. Jekyll and Mr. Hyde"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMatyas Sandor (University of Wisconsin-Madison, USA)
"CNS Immunity Against Tuberculosis: TB or Not TB"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRobyn Klein (Washington University School of Medicine in St. Louis, USA)
"Infectious Immunity Alters Brain Function"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmChristopher Hunter (University of Pennsylvania, USA)
"Toxoplasmic Encephalitis - Parasite Entry and Protective Immunity"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1R13-AI129380-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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