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Physical Science of Cancer
Gordon Research Conference

Cancer Forces, Structures, and Mathematical Predictions

Dates

February 5-10, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Dennis E. Discher

Vice Chair:
Franziska Michor

Meeting Description

Note 1: Sunday, February 5, is the same day as the Super Bowl in Houston. For those attending this meeting, early booking of flights and rental cars into Houston is recommended.

Note 2: Apply by November 23 with abstract submission to be considered for one of many Short Talks.

Tumor tissue is often physically abnormal, and relationships to the altered genomes, selection, and heterogeneity of cancer are all crucial for understanding and likely for therapy. Mechanical properties, transport processes with reaction-diffusion, and even thermal fluctuations at the molecular scale can all modulate tumor cells, the tumor microenvironment, and the host. This is the physical context for the many genetic and epi-genetic changes that are increasingly being mapped and mathematically modeled in various cancers. How such physical changes/processes are manifest at multiple scales and contribute to cancer growth are current questions to be addressed by the many biophysicists and mathematically talented theorists now measuring and predictively modeling cancer cells and tumor tissues. To push back the boundaries of physics impacting biology, it is essential that the development of new and improved methodologies continues -- with quantitation in real physical units of force, length, time, and concentration providing some of the hard data that modelers can use for concrete physical predictions in cancer. An intimate interplay of Physical Measurement and Predictive Mathematics is precisely how the physical sciences has made progress for decades. This new GRC on Physical Science of Cancer aims to play a crucial role by providing a forum for the presentation and discussion of novel concepts and approaches. The current challenges in the field that we seek to focus on in sessions range from topics in Migration-Invasion mechanisms and Genomic Instability to Mathematical physics-based modeling for novel clinical trials in Immuno-Oncology.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Migration-Invasion Physics of Single Cancer Cells and Populations
Discussion Leader: Steven Rosenfeld (Cleveland Clinic, USA)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:20 pmXavier Trepat (Institute for Bioengineering of Catalonia (IBEC), Spain)
"Physical Guidance of Collective Cancer Cell Invasion"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmDouglas Robinson (Johns Hopkins School of Medicine, USA)
"Pancreatic Cancer Invasion: From Theory to Inhibitors"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmArmando del Rio Hernandez (Imperial College London, United Kingdom)
"Pancreatic Cancer, Mechanobio, and Vitamin-A"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJerome Irianto (University of Pennsylvania, USA)
"Repair Factor Loss and Mutation in Pore Invasion"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTumor Matrix Stiffening and Cytoskeletal Stress Under Flow and Pressure
Discussion Leader: Princess Imoukhuede (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:35 amPaul Janmey (University of Pennsylvania, USA)
"Liver Cancer, Fibrosis, and Novel Rheology"
9:35 am - 9:45 amDiscussion
9:45 am - 10:15 amJosef Kaes (Leipzig University, Germany)
"Rigid Tumors and Soft Cells"
10:15 am - 10:25 amDiscussion
10:25 am - 10:45 amCoffee Break
10:45 am - 11:15 amMarija Plodinec (University of Basel, Switzerland)
"Nanomechanics of Living Epithelia and Clinical Trials"
11:15 am - 11:25 amDiscussion
11:25 am - 11:55 amKonstantinos Konstantopoulos (Johns Hopkins University, USA)
"Cell Sensing and Motility in Confinement"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:25 pmJian Liu (National Institutes of Health, USA)
"Oscillations Confer Mechanosensitivity of Adhesions"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCancer Physics in Adhesive Signals and Cell Fates
Discussion Leader: Armando del Rio Hernandez (Imperial College London, United Kingdom)
7:30 pm - 8:00 pmMichael Sheetz (Mechanobiology Institute, Singapore (MBI), National University of Singapore, Singapore)
"Transformation by Depletion of Rigidity Sensing Sarcomeres"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmHerbert Levine (Rice University, USA)
"Phenotypic Changes en Route to Metastasis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmClaudia Fischbach (Cornell University, USA)
"Signaling from Matrix"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNuclear Physics in Cancer
Discussion Leader: Samuel Safran (Weizmann Institute of Science, Israel)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amG.V. Shivashankar (National University of Singapore, Singapore)
"Nuclear Organization and Geometry"
9:40 am - 9:50 amDiscussion
9:50 am - 10:20 amJohn Marko (Northwestern University, USA)
"Structure and Mechanics of Chromosomes and Nuclei"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCoffee Break
10:50 am - 11:20 amKatarina Wolf (Radboud University Medical Centre, The Netherlands)
"Cancer Cell Migration and the Nucleus"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShamik Sen (Indian Institute of Technology Bombay, India)
"MMPs, Actomyosin, and Nuclear Softening in Invasion"
11:45 am - 11:50 amDiscussion
11:50 am - 12:20 pmAlexander Anderson (Moffitt Cancer Center, USA)
"Metabolic Heterogeneity in Growth and Treatment"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSite-Specific Chromatin Physics
Discussion Leader: Rong Li (Johns Hopkins University, USA)
7:30 pm - 8:00 pmThomas O'Halloran (Northwestern University, USA)
"Metals in the Nucleus: Modulation of Chromatin Structure"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRoger Greenberg (University of Pennsylvania, USA)
"Visualizing Break Dynamics in Cancer Cells"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmXin Li (University of Texas at Austin, USA)
"Interplay of Driver and Deleterious Mutations"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmLinda Kenney (Mechanobiology Institute, Singapore)
"Bacteria on Solid Tumors and Transcriptional Regulation"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCancer Genome Principles and Computations
Discussion Leader: Nancy Zhang (University of Pennsylvania, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amRong Li (Johns Hopkins University, USA)
"Evolvability Scales with Growth Suppression"
9:40 am - 9:50 amDiscussion
9:50 am - 10:20 amOrly Alter (University of Utah, USA)
"Genomic Signal Processing"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCoffee Break
10:50 am - 11:20 amNiko Beerenwinkel (ETH Zurich, Switzerland)
"Cancer Evolution: Models and Computational Inference"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShaon Chakrabarti (Dana Farber Cancer Institute, Harvard Medical School, USA)
"Hidden Heterogeneity from Single-Cell Lineage Data"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmPablo Camara (Columbia University, USA)
"Topological Analysis of Single Cancer Cells"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmImre Derenyi (Eötvös Loránd University, Hungary)
"Tissue-Specific Stem Cells in Prevention of Cancer"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCancer Dynamics Theory and Experiment
Discussion Leader: Nataly Kravchenko-Balasha (The Hebrew University of Jerusalem, Israel)
7:30 pm - 8:00 pmJean-Francois Joanny (ESPCI Paris, France)
"Soft Matter Theory of Tumor Growth"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmAndre Levchenko (Yale University, USA)
"Cancer Cell Migration in Complex Topographies"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmValerie Weaver (University of California, San Francisco, USA)
"Migration and Mechanosensing by Cancer Cells in 3D"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMultiscale Physics Math and Experimental Models
Discussion Leader: Charles Wolgemuth (University of Arizona, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amLisa Manning (Syracuse University, USA)
"Jamming in Heterogeneous, 3D, Cancer-Like Tissues"
9:40 am - 9:50 amDiscussion
9:50 am - 10:20 amDavid Odde (University of Minnesota, USA)
"Simulating Mechanics of Glioma Migration"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCoffee Break
10:50 am - 11:20 amVittorio Cristini (University of Texas Health Science Center at Houston, USA)
"Patient-Specific Mechanistic Modeling of Drug Response"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amJordi Alcaraz Casademunt (University of Barcelona, Spain)
"Fibroblasts from Lung Cancer: One Size Does Not Fit All"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmOvijit Chaudhuri (Stanford University, USA)
"Viscoelasticity and Basement Membrane Invasion"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmIan Wong (Brown University, USA)
"EMT in 3D Tumor Organoids"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMathematical and Physics-Based Modeling for Novel Clinical Trials
Discussion Leader: Russell Rockne (Beckman Research Institute, City of Hope National Medical Center, USA)
7:30 pm - 8:00 pmMithat Gonen (Memorial Sloan Kettering Cancer Center, USA)
"Prognostic and Predictive Models for Clinics"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmLance Munn (Harvard Medical School, USA)
"Matrix, Pressure, and Clinical Trials"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJessica Cunningham (Moffitt Cancer Center and Research Institute, USA)
"Evolution-Based Therapies"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmBart Smeets (KU Leuven Research and Development / MeBioS, Belgium)
"Phase Diagrams of Self-Propulsion with Contact Inhibition"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA213578-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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