Gordon Research Conferences
Meeting Details
Search:
  GO

Wnt Signaling
Gordon Research Conference

Wnt Signaling: A Pathway Implicated in Animal Development, Stem Cell Control and Cancer

Dates

August 6-11, 2017

Location

Stoweflake Conference Center
Stowe, VT

Organizers

Chair:
Roeland Nusse

Vice Chair:
Karl Willert

Meeting Description

The 2017 Gordon Research Conference titled "Wnt Signaling: A Pathway Implicated in Animal Development, Stem Cell Control and Cancer" seeks to advance our understanding of how the highly conserved Wnt signaling pathway influences developmental processes and disease. The proposed meeting will cover a broad spectrum of biological systems, approaches and methodologies and bring together a diverse group of scientists, including structural biologists, embryologists, and stem cell and cancer researchers.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmWnt Proteins: Structures and Modifications
Discussion Leader: Roeland Nusse (Stanford University, USA)
7:40 pm - 8:10 pmJean-Paul Vincent (Francis Crick Institute, United Kingdom)
"Secretion and Release of Wnts"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmYvonne Jones (Division of Structural Biology (STRUBI), University of Oxford, United Kingdom)
"Structural Analysis of Wnt Signaling Components"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmRami Hannoush (Genentech, Inc., USA)
"Biochemical Analysis of Wnt Signaling"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmWnt Signal Transduction
Discussion Leader: Karl Willert (University of California, San Diego, USA)
9:00 am - 9:25 amXi He (Harvard Medical School, USA)
"Novel Regulators of Wnt Signaling"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amWilliam Weis (Stanford University, USA)
"Molecular Mechanisms in Wnt/β-Catenin Signaling"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amMadelon Maurice (University Medical Center Utrecht, The Netherlands)
"Wnt Pathway Tumor Suppressors: Mechanisms and Mutations"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Harald Junge (University of Colorado Boulder, USA)
"Norrin-Induced Frizzled4 Endocytosis and Endo-Lysosomal Trafficking Control Retinal Angiogenesis and Barrier Function"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Wenqing Xu (University of Washington, USA)
"Structural Basis of Norrin-Mediated Wnt/Beta-Catenin Signaling"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Chris Cho (Johns Hopkins School of Medicine, USA)
"Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian Central Nervous System Angiogenesis and Blood-Brain Barrier Regulation"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Karsten Melcher (Van Andel Research Institute, USA)
"Wnt5a Promotes Frizzled-4 Signalosome Assembly by Stabilizing Cysteine-Rich Domain Dimerization"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Junichi Takagi (Institute for Protein Research, Osaka University, Japan)
"Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-Glycosylation and the Binding of Wnt-Antagonist Dkk1"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmWnt Signaling at the Membrane
Discussion Leader: William Weis (Stanford University, USA)
7:30 pm - 7:55 pmMichael Boutros (German Cancer Research Center (DKFZ), Germany)
"Secretion of Wnt Signals"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmVivian Budnik (University of Massachusetts Medical School, USA)
"Wnt Signaling in Development"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmChristof Niehrs (Institute of Molecular Biology (IMB), University of Mainz, Germany)
"Novel Regulators of LRP6"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWnt Signaling in the Nucleus and Beyond
Discussion Leader: Xi He (Harvard Medical School, USA)
9:00 am - 9:25 amKenneth Cadigan (University of Michigan, USA)
"Wnt Target Gene Regulation: Not All Binding Sites Are Created Equal"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amTerry Yamaguchi (National Cancer Institute at Frederick, NIH, USA)
"Developmental Roles of Wnt Signaling"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amMariann Bienz (Medical Research Council, United Kingdom)
"On-Off Switching of the Wnt Enhanceosome"
11:05 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Claudio Cantù (University of Zurich, Switzerland)
"An Ancient Tissue-Specific Transcriptional Module Drives Wnt/Beta-Catenin Signaling During Heart Development"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Lei Ji (Novartis Institutes for Biomedical Research, USA)
"The SIAH E3 Ubiquitin Ligases Promote Wnt/Beta-Catenin Signaling Through Mediating Wnt-Induced Axin Degradation"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Ben Major (University of North Carolina at Chapel Hill, USA)
"Competitive Kinase Enrichment Proteomics to Instruct Drug Repurposing and Circumvent Clinical Toxicity - Unexpected WNT Activators"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Yashi Ahmed (Dartmouth College, USA)
"APC Promotes Axin Phosphorylation in both the Activation and Inhibition of Wingless/Wnt Signaling"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Caroline Alexander (University of Wisconsin-Madison, USA)
"Lrp5: More than a Role in Wnt Signaling"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCell Biology of Wnt Proteins and Signaling
Discussion Leader: Rami Hannoush (Genentech, Inc., USA)
7:30 pm - 7:55 pmEthan Lee (Vanderbilt University, USA)
"A Model for Wnt Receptor Activation by APC"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmDavid Virshup (Duke-NUS Medical School, Singapore)
"Wnt's Journey to the Membrane"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:50 pmSelected from Poster Abstracts: Stephane Angers (University of Toronto, Canada)
"Identification of FZD5 as a Genetic Vulnerability in RNF43 Mutant Cancers"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:10 pmSelected from Poster Abstracts: Yimin Zou (University of California, San Diego, USA)
"Sonic Hedgehog Is a Midline Switch for Wnt/Planar Cell Polarity Signaling in Commissural Axon Guidance"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWnt in Stem Cells and Regeneration
Discussion Leader: Edward Morrisey (University of Pennsylvania, USA)
9:00 am - 9:25 amArial Zeng (Chinese Academy of Sciences, China)
"PROCR in Regulating Mammary Stem Cells and Beyond"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amPeter Reddien (Whitehead Institute for Biomedical Research, USA)
"The Role of Wnt Signaling from Muscle in Planarian Regeneration"
10:00 am - 10:10 amDiscussion
10:10 am - 10:45 amCoffee Break
10:45 am - 10:55 amSelected from Poster Abstracts: Sergei Sokol (Icahn School of Medicine at Mount Sinai, USA)
"MAL Proteins Mediate Wnt Signaling During Neural Crest Specification"
10:55 am - 11:00 amDiscussion
11:00 am - 11:10 amSelected from Poster Abstracts: Derk Ten Berge (Erasmus Medical Center, The Netherlands)
"Wnt and MEK Signals Act Sequentially in Naïve-Primed Pluripotency Transition via an Embryonic Rosette State"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Elizabeth Vincan (University of Melbourne, Australia)
"Frizzled7 Functions as a Wnt Receptor in Gastrointestinal Epithelial Stem Cells: Implications for Cancer Growth and Progression"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Richard Dorsky (University of Utah, USA)
"Lef1-Dependent Hypothalamic Neurogenesis Inhibits Anxiety"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Stephanie Grainger (University of California, San Diego, USA)
"Independent Wnt/Fzd Signals Are Required for Hematopoietic Stem Cell Development"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Stacey Ogden (St. Jude Children's Research Hospital, USA)
"In Vitro Cytoneme Analysis Provides Insight into In Vivo Cyotneme Regulation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Ryan Range (Mississippi State University, USA)
"The Emerging Wnt Signaling Network that Governs Anterior-Posterior Neuroectoderm Patterning in Sea Urchin Embryos"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmSystems Biology of Wnt Signaling
Discussion Leader: Mariann Bienz (Medical Research Council, United Kingdom)
7:30 pm - 7:55 pmMarc Kirschner (Harvard Medical School, USA)
"The Intracellular Dynamics of Disheveled and Axin at the Single Molecule Level"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmLawrence Lum (University of Texas Southwestern Medical Center, USA)
"Interrogating Wnt Signaling with the Help of Large Molecular Libraries"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmMarian Waterman (University of California, Irvine, USA)
"Wnt Signaling Heterogeneity in Cancer"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWnt in Development
Discussion Leader: Kenneth Cadigan (University of Michigan, USA)
9:00 am - 9:25 amEdward Morrisey (University of Pennsylvania, USA)
"Wnt Responsiveness Defines Epithelial and Mesenchymal Niches in the Adult Lung"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amBryan Phillips (University of Iowa, USA)
"Asymmetric Cell Division During Development Requires Wnt Signaling and Tight Control of β-Catenin Levels"
10:00 am - 10:10 amDiscussion
10:10 am - 10:45 amCoffee Break
10:45 am - 10:55 amSelected from Poster Abstracts: Kaitlin Basham (University of Michigan, USA)
"Wnt Inhibitor ZNRF3 Is a Critical Regulator of Adrenal Homeostasis"
10:55 am - 11:00 amDiscussion
11:00 am - 11:10 amSelected from Poster Abstracts: Bo Gao (The University of Hong Kong, Hong Kong SAR China)
"Wnt-Induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: Tohru Ishitani (Institute for Molecular and Cellular Regulation, Gunma University, Japan)
"The Noise-Cancelling System Supporting Precise Wnt/β-Catenin Signaling-Mediated Vertebrate Tissue Patterning"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Akira Kikuchi (Graduate School of Medicine, Osaka University, Japan)
"The Dickkopf1-CKAP4 Axis Creates a Novel Cancer Cell Proliferation Pathway and May Represent a Therapeutic Target for Cancer"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Kibeom Kim (California Institute of Technology, USA)
"Two-Element Transcriptional Regulation in the Canonical Wnt Pathway"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Danielle Kopke (Vanderbilt University, USA)
"A Secreted HSPG Regulates Extracellular Wnt Signaling to Coordinate Synaptogenesis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Tuomas Tammela (Massachusetts Institute of Technology, USA)
"A Wnt-Producing Niche Maintains Proliferative Potential and Drives Tumor Progression in Lung Adenocarcinoma"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmWnt Signaling in Disease
Discussion Leader: Michael Boutros (German Cancer Research Center (DKFZ), Germany)
7:30 pm - 7:55 pmMatthew Warman (Boston Children's Hospital, Harvard University, USA)
"Wnt Signaling in Bone Homeostasis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmBart Williams (Van Andel Research Institute, USA)
"Wnt Signaling in Skeletal Development and Homeostasis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmOwen Sansom (Beatson Institute for Cancer Research, United Kingdom)
"Assessing the Impact of Wnt Inhibition on Stem Cells and Tumourigenesis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Vishal Deshmukh (Samumed, LLC, USA)
"Discovery of a Small Molecule Inhibitor of the Wnt Pathway (SM04690) as a Potential Disease Modifying Treatment for Knee Osteoarthritis"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter