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Translation Machinery in Health & Disease (GRS)
Gordon Research Seminar

Unveiling Mechanisms to Understand Pathogenesis

Dates

March 18-19, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chairs:
Eva Maria Novoa & Adrian G. Torres

Meeting Description

The Gordon Research Seminar on Translation Machinery in Health and Disease is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The focus of this meeting is to provide fundamental mechanistic insights on the role the translation machinery plays in physiological and pathogenic scenarios. Topics covered by an interdisciplinary selection of speakers will include: the use of systems biology and large dataset analyses to study gene translation at transcriptomics and proteomics scale, the description of novel non-canonical functions of the components of the translation machinery, and the emerging roles of post-transcriptional RNA modifications.

Related Meeting

This GRS was held in conjunction with the "Translation Machinery in Health & Disease" Gordon Research Conference (GRC). Refer to the associated GRC program page for more information.

Contributors

Meeting Program

Saturday
2:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmKeynote Session: Beyond the Canonical View of Protein Translation
Discussion Leader: Adrian Torres (Institute for Research in Biomedicine (IRB Barcelona), Spain)
3:45 pm - 4:20 pmChristine Mayr (Memorial Sloan Kettering Cancer Center, USA)
"New Insights into 3'UTR-Mediated Protein-Protein Interactions"
4:20 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRNA Modifications, Ribosomes and Disease
Discussion Leader: Mary Anne Rubio (The Ohio State University, USA)
7:30 pm - 7:50 pmMarkus Schosserer (University of Natural Resources and Life Sciences, Vienna, Austria)
"Characterization of Ribosomal RNA Base Methylations Modulating Life and Healthspan"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmElif Sarinay Cenik (Stanford University, USA)
"Molecular Modeling of Systemic Effects of Ribosomal Protein Imbalance"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJean-Denis Beaudoin (Yale University, USA)
"Ribosomes Sculpt mRNA Structure During Embryogenesis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmTara Peters (University of Miami, USA)
"Preclinical Assessment of Elatol as a Novel eIF4A Inhibitor for Cancer Therapeutics"
9:20 pm - 9:30 pmDiscussion
Sunday
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amTranslational Control
Discussion Leader: Jean-Denis Beaudoin (Yale University, USA)
9:00 am - 9:20 amNathaniel Robichaud (McGill University, Canada)
"Translational Control of the Tumour Microenvironment"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSeungjae Jeong (Seoul National University, South Korea)
"Human Threonyl-tRNA Synthetase Controls Translation Initiation via Specific Interaction with eIF4E Homologous Protein"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amKyle Mohler (The Ohio State University, USA)
"Editing of Misaminoacylated tRNA Controls the Sensitivity of Amino Acid Stress Responses in Saccharomyces cerevisiae"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amErin Kennedy (University of Ottawa, Canada)
"Using Yeast to Study the Pathobiology of SIFD"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session

Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: How to Succeed in Science?
Discussion Leader: Eva Maria Novoa (Garvan Institute of Medical Research, Australia)
1:30 pm - 2:15 pmJonathan Yewdell (National Institutes of Health, USA)
"How to Succeed in Science Without Really Trying"
2:15 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill in GRS Evaluation Forms
3:00 pmSeminar Concludes
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