| Session 1 |
Sunday PM (7:30 - 10) |
| Topic: Structure-Function |
Discussion leader: Mark Nelson, Tufts
|
Lorne Golub, SUNY Stony Brook
Non-antimicrobial properties of TCs: Where are we now? |
M. Ryan, SUNY Stony Brook
Screening for general non-antibiotic properties of TCs |
J. Thomas, Univ. WV
Are non-antibiotic TCs truly non-antibiotic? |
| Session 2 |
Monday AM (8:30 - 12:30) |
| Topic: TC Chemistry |
Discussion leader: Stuart Levy, Tufts
Potential advantages of non-antimicrobial antibiotics for medical usage |
Mark Nelson
TC structure-function chemistry |
David Auld, Harvard
Zinc metalloenzymes and prospects for their inhibition |
| Coffee break |
S. Simon, SUNY Stony Brook
Competitive & Non-competitive inhibition of MMPs and serine proteases |
J. Hlavka, Innapharma
Design considerations in CMTs |
| Group Photo |
| Session 3 |
Monday PM (7:30 - 10) |
| Topic: Experimental pathology - I |
Discussion leader: R. Greenwald
|
J. Steinmeyer, Giessen
Effect of TCs on cartilage |
G. Opdenakker, Leuven
Inhibition of MMPs by TCs |
A. Bottaro, Univ Rochester
Effects of TCs on B cell activation and function |
G. Nieman, Syracuse
Use of TCs in ARDS models |
| Session 4 |
Tuesday AM (8:30 - 12:30) |
| Topic: TC effects on gene expression - I |
Discussion leader: Dr. A. Amin, NYU
|
T. Sorsa, Univ Helsinki
Effects of doxycycline and CMTs on trypsin-2 expression and invasion of COLO-205 cells and in vivo expression of MMPs
|
Roeland Hanemaaijer, TNO Netherlands
Regulation of MMP activity and MMP synthesis by doxycycline and CMTs
|
A. Amin, NYU
Regulation of inflammatory mediators by tetracycline
|
| Coffee Break |
C. Ritchlin, Rochester
Effect of TCs on cytokines |
K. Hasty, Univ. Tenn
Effect of TCs on gene expression of MMPs |
K. Kirkwood, SUNY Buffalo
Effect of TCs on IL-1ß and IL-6 |
| Session 5 |
Tuesday PM (7:30 - 10) |
| Topic: Non-antibiotic properties of non-TC antibiotics |
Discussion leader: Y. Schoenfeld, Israel
|
Y. Schoenfeld, Israel
Autoimmune benefits from antibiotic treatment: the cytokine plot |
Prof. Lamy, Belgium
Antioxidant properties of beta-lactam antibiotics |
L. Kesner, Downstate
Protease inhibition by bacitracin |
J. Lakritz, Univ. MO
Effect of macrolides on bronchoalveolar lavage fluid |
| Session 6 |
Wednesday AM (8:30 - 12:30) |
| Topic: TC effects on gene expression - II |
Discussion leader: Sara Cunningham, CLONTECH
|
Prof. H. Bujard, Heidelberg
Generation of conditional mutants by tetracycline dependent control of gene activities
|
Wolfgang Hillen, Erlangen
Understanding how the TC-dependent repressor works and modifying it for use in eukaryotes
|
Glenn Fishman, Mt Sinai NY
TC regulated conditional transgene expression |
Patrick Tremblay, UCSF
PrP Transgene Expression |
W. Hinrichs, Inst. for Crystallography, Berlin
Mechanism of tetracycline repressor induction by tetracyclines and preliminary view of the reverse tet repressor |
| Poster Session - Wednesday 4:00 - 6:00 PM |
| Session 7 |
Wednesday PM (7:30 - 10) |
| Topic: Experimental pathology - II |
Discussion leader: Yrjo Konttinen, Helsinki
|
R. Thompson, Wash Univ, So Louis
Effects of TCs on aneurysm development |
Michelle Bendeck, University of Toronto
Doxycycline inhibits neointimal thickening in the injured rat carotid artery |
| Coffee Break |
Jari Koistinaho, Univ Kuopio
Cerebral ischemia |
Franck Sturtz, Paris
Antiviral effects of TCs |
| Session 8 |
Thursday AM (8:30 - 12:30) |
| Topic: Effects of TCs on neoplastic systems |
Discussion leader: M. Hendrix, Univ. Iowa
|
B. Lokeshwar, Univ Miami
TCs and induction of programmed cell death (apoptosis) in cancer cells |
M. Hendrix, Univ. Iowa
Effects of TCs on tumor growth, angiogenesis and metastasis |
| Coffee Break |
P. Grabowski, Smith & Nephew
Induction of apoptosis in osteoclasts |
R. Fife, Indiana
|
| Business Meeting |
| Session 9 |
Thursday PM (7:30 - 9:00) |
| Topic: Unusual TC-related phenomena |
George Armelagos, Emory Univ.
Archaelogic evidence of TC effects on ancient bones |
| 9:00 - 12:00 |
Reception |
