SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Targeting the Genome |
| Chair: Christian BAILLY |
| Christian BAILLY (Pierre Fabre, Castres, France)
"Targetting the Nuclear and Mitochondrial DNA with Novel Anticancer Agents" |
| Stephen HOWELL (University of California, San Diego)
"The role of translesion synthesis in the development of platinum drug resistance" |
| John ESSIGMANN (MIT)
"Novel DNA damaging anticancer agents that hijack transcription factors" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Translation Initiation Pathways for Cancer Therapy |
| Chair: Peter HOUGHTON |
| Peter HOUGHTON (St Jude Children Research Hospital)
"Rapamycins as Cancer Therapeutics" |
| Chris PROUD (University of British Columbia)
"Targeting Signaling Downstream of mTOR in Cancer Chemotherapy" |
| Sara KOZMA (University of Cincinnati)
"TOR Deletion in Drosophila and Mouse" |
| Jerry PELLETIER (McGill University, Montreal)
"High-Throughput Screens for Inhibitors of Translation Initiation" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | c-myc and Transcription |
| Chair: Peter K. VOGT |
| Peter K. VOGT (Scripps Research Institute, La Jolla, CA)
"Small Molecule Modulators of the Myc-Max Network" |
| Edward PROCHOWNIK (Children's Hospital of Pittsburgh)
"Inhibitors of Myc-Max Dimerization" |
| Lubomir VASSILEV (Hoffmann-La Roche, Nutley, NJ)
"Controlling p53-MDM2 Interaction" |
| Kevin GARDNER (UT Southwestern Medical Center, Dallas, TX)
"Small Molecule Inhibitors of HIF: ARNT and CREB:CBP Interactions" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Tantalizing Thanatos - Cell Death as a Therapeutic Goal |
| Chair: Guido KROEMER |
| Guido KROEMER (CNRS, Villejuif, France)
"Apoptosis and Genomic Instability in Cancer" |
| John C. REED (The Burnham Institute, La Jolla, CA)
"Apoptosis-Based Drug Discovery" |
| Jerry E. CHIPUK (La Jolla Institute for Allergy and Immunology, San Diego, CA)
"PUMA couples the nuclear and cytoplasmic pro-apoptotic function of p53" |
| Craig THOMPSON (Abramson Family Cancer Research Institute, Philadelphia, PA)
"Therapeutic Regulation of Non-apoptotic Forms of Cell Death" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Survival Pathways |
| Chair: Phillip DENNIS |
| Phillip DENNIS (CCR, NCI, NIH)
"The Serine/Threonine Kinase Akt as a Target in Cancer" |
| William PAO (Memorial Sloan-Kettering Cancer Center, New York)
"Elucidating Mechanisms of EGFR-Dependent Tumor Maintenance" |
| Shigeki MIYAMOTO (University of Wisconsin, Madison, WI)
"Activation of NF-kB by DNA-Damaging Anticancer Agents" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The p53-Mdm2 and Stress Response Pathways |
| Chair: Wafik S. EL-DEIRY |
| Thanos HALAZONETIS (Wistar Institute, Philadelphia, PA)
"Recognition and Targeting of Checkpoint Response Pathways for Therapy" |
| Andrei GUDKOV (Cleveland Clinic Foundation, Cleveland, OH)
"Targeting p53 to reduce treatment toxicity" |
| Allan M. WEISSMAN (CCR, NCI, NIH)
"Small Molecule Antagonists of MDM2" |
| Wafik S. EL-DEIRY (University of Pennsylvania School of Medicine, Philadelphia)
"Targeting p53 Responses in p53-Deficient Cells" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Exploiting Hypoxia in Cancer Treatment |
| Chair: J. MARTIN BROWN (Stanford University) |
| Adrian HARRIS (Oxford University, UK)
"New Hypoxia and Copper Dependent Pathways Regulating Angiogenesis" |
| Giovanni MELLILO (NCI, NIH)
"Novel Small Molecule Inhibitors of HIF-1" |
| William WILSON (University of Auckland, Auckland, New Zealand)
"Dinitrobenzamide Mustards: Prodrugs that Exploit Tumor Hypoxia via a Bystander Effect" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Hip-Hop on Microtubules: Cytoskeleton Takes Center Stage in Cancer Therapy |
| Chair: Eve GIANNAKAKOU |
| Ken DOWNING (Lawrence Berkeley National Laboratory, Berkeley, CA)
"Structure of Tubulin and Complexes with Anticancer Drugs" |
| Mary Ann JORDAN (University of California at Santa Barbara) "Nature Mimics Itself: Modulation of Microtubule Dynamics by Drugs and Endogenous Regulators" |
| Paraskevi (Evi) GIANNAKAKOU (Emory University, Atlanta, GA)
"HIF-Hop on Microtubules: Studies on mRNA Trafficking and Translation" |
| Tito FOJO (CCR, NCI, NIH)
Microtubule Targeting Agents: Beyond the Spindle" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Unconventional Therapeutic Chemical Approaches |
| Chair: Greg VERDINE |
| Greg VERDINE (Harvard University)
"Stapled Peptides: Synthesis Meets Biologics" |
| Julian ADAMS (Infinity Pharmaceuticals) |
| Saul ROSENBERG (Abbott Pharmaceuticals)
"Small-molecule inhibitors of Bcl-2 family proteins" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |