SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote talks |
| Welcome |
7:30 pm - 8:00 pm | Tom Kunkel, National Institute of Environmental Health Sciences, NIH Investigating DNA Transactions That Determine Replication Fidelity |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Phil Hanawalt, Stanford University Why can't a mouse be more like a man? |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Doug Green, La Jolla Institute for Allergy and Immunology The Cell's Decision to Die |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genotoxicity of endogenous lesions and BER |
| Session Chair: Sam Wilson, National Institute of Environmental Health Sciences, NIH
|
9:00 am - 9:30 am | Sam Wilson Phenotypes of Base Excision Repair Deficiency |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Arthur Grollman, University of New York, Stony Brook
Recognition and Repair of oxidative DNA damage |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Barbara Sedgwick, Cancer Research UK
Direct reversal of DNA alkylation damage by the E. coli AlkB dioxygenase and two human homologs |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Ehrling Seeberg, University Of Oslo
Removal of base damage induced by oxidizing and alkylating agents |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Keith Caldecott, Genome Damage and Stability Centre, University of Sussex Mammalian DNA Single Strand break repair |
12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:25 pm | Poster Presentation |
12:25 pm - 12:30 pm | Discussion |
12:45 pm | Lunch / Photo |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster presentations |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lesion bypass and fidelity |
| Session Chair: Errol Friedberg, UT South Western Medical Center |
7:30 pm - 7:55 pm | Errol Friedberg
Mammalian DNA Polymerase Kappa: A TLS Polymerase for Oxidative Base Damage |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Robert Fuchs, CNRS, Strasbourg
Defining the switch between specialized and replicative DNA polymerases during Translesion synthesis. |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Roger Woodgate, NICHD, NIH
Investigating the many protein-protein interactions that regulate
the activities of Y-family DNA polymerases. |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Alan Lehmann, Genome Damage & Stability Centre, University of Sussex TLS polymerases like to dance together |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genotoxic damage responses to alkylation damage, bulky lesions and DNA mismatches |
| Session Chair: Priscilla Cooper, Lawrence Berkeley National Laboratory |
9:00 am - 9:30 am | Priscilla Cooper Coordinating repair of oxidative DNA damage with transcription and replication |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Nicholas Geacintov, New York University
The role of structural factors in the repair of bulky DNA lesions |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Titia Sixma, Netherlands Cancer Institute
DNA mismatch repair enzyme Muts: an asymmetric ATPase |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Akira Yasui, Tohoku University
Analysis of Damage Responses by foreign repair proteins in Mammals |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Jean Mark Egly, IGBMC, France
The masked role of the XPD subunit of the transcription/DNA repair factor TFIIH |
12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:25 pm | Poster Presentation |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster presentations |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Responses to DSBs and replication blockage |
| Session Chair. John Tainer, Scripps Research Institute |
7:30 pm - 7:55 pm | John Tainer Envisioning Structural Implications for Repair Responses to DSB and Replication Blockage |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Alan D'Andrea, Harvard Medical School
The Fanconi Anaemia/BRCA Pathway in DNA Repair |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Steve West, Cancer Research UK
Double strand break repair by homologous recombination |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Dmitry Gordenin, National Institute of Environmental Health Sciences, NIH Genotoxicity caused by inhibition of a mutation avoidance system |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Damage inducible checkpoints and signalling |
| Session Chair: Tony Carr, Genome Damage & Stability Centre,
University of Sussex |
9:00 am - 9:30 am | Tony Carr, Genome Damage & Stability Centre, University of Sussex Regulation of RNR by checkpoints and the signalosome |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Steve Jackson, Wellcome Trust/Cancer Research UK Institute Early events in the DNA damage response |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Rachel Klevit, University of Washington
Determinants for the Assembly of an Active BRCA1/BARD1 Ubiquitin Ligase |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Marco Foiani, F.I.R.C Institute of Molecular Oncology Controlling the integrity of replicating chromosomes: the checkpoint connection |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Anton Gartner, Max Planck Institute
The roads to death: DNA damage induced programmed cell death in C.elegans |
12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:25 pm | Poster Presentation |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster presentations |
6:00 pm | Dinner |
7:15 pm - 7:30 pm | Business meeting |
7:30 pm - 9:30 pm | Mutagenesis and somatic mutation in vivo |
| Session Chair: Bryn Bridges, Genome Damage & Stability Centre, University of Sussex |
7:30 pm - 7:40 pm | Bryn Bridges Introductory remarks |
7:40 pm - 8:00 pm | John Cairns, Oxford The risk of Mutation |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Ray Monnat, University of Washington Human epithelial somatic mutation: mechanistic origins and disease links |
8:25 pm - 8:45 pm | Barry Finette, University of Vermont Emergence of mutagenic mechanisms following genotoxic exposure in humans |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:15 pm | Michael Neuberger, Laboratory of Molecular Biology, UK DNA determination and the generation of Antibody diversity |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Responding to the damage done: Communication between the repair and apoptotic machinery |
| Session Chair: John Hickman, Institut de Recherches Servier
|
9:00 am - 9:30 am | John Hickman To die or not to die - Integration of signals from genomic damage |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Ben Van Houten, National Institute of Environmental Health Sciences, NIH Oxidative stress-induced mitochondrial DNA damage: sorting out life and death decisions |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Carol Prives, Columbia University
Regulation of the p53/Mdm2 circuit |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Caroline Dive, CRC Molecular and Cellular Pharmacology Group Regulation of Bcl-2 family members and apoptosis by cellular damage signals |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Bert Van der Horst, Erasmus MC, Rotterdam
Relationship between DNA repair and aging |
12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:25 pm | Poster Presentation |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster presentations |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New advances in Toxicogenomics |
| Session Chair: Ruth Roberts, Aventis Pharma
|
7:30 pm - 7:55 pm | Ruth Roberts Synergising new technologies: application to molecular toxicology |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Leona Samson, MIT, Boston
Complex responses to alkylating agents |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:55 pm | Veronique Thybaud, Aventis Pharma
Can toxicogenomics be used to differentiate between direct and indirect genotoxic compounds? |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Sri Nagalla, Oregan Health Sciences University
Toxicology In Silco : Mapping the genotoxic gene and protein networks |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:45 am - 8:30 am | Breakfast |
9:00 am | Depart |