| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and check-in |
| 4:30 pm - 6:00 pm | Welcome Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcome / Announcements |
| 7:35 pm - 9:30 pm | DEVELOPMENTAL GLYCOBIOLOGY |
| Discussion Leader: William J. Lennarz (Stony Brook) |
| 7:35 pm - 7:40 pm | William J. Lennarz (Stony Brook)
Introduction |
| 7:40 pm - 8:08 pm | Pamela Stanley (Albert Einstein College of Medicine)
"Roles for O-fucose glycans on Notch receptors in mammalian development" |
| 8:08 pm - 8:36 pm | Joseph Yost (University of Utah)
"Regulation of left-right development by syndecan and O-sulfotransferases" |
| 8:36 pm - 9:04 pm | Kelly Ten Hagen (NIH)
"Using Drosophila melanogaster to dissect the biological role of mucin-type O-linked glycosylation" |
| 9:04 pm - 9:17 pm | Ken Kitajima (Nagoya University)
"An essential role of carbohydrate-enriched membrane microdomains (rafts) in gastrulation of medaka fish, Oryzias latipes" |
| 9:17 pm - 9:30 pm | Gerado Vasta (University of Maryland-Baltimore)
"The galectin repertoire of zebrafish (Danio rerio) during early embryogenesis: biochemical and molecular characterization" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Conference Photograph Session |
| 9:00 am - 12:30 pm | CANCER GLYCOBIOLOGY |
| Discussion Leader: Ajit Varki (UCSD) |
| 9:00 am - 9:05 am | Ajit Varki (UCSD)
Introduction |
| 9:05 am - 9:33 am | Steve Rosen (UCSF)
"The Sulfs: extracellular endosulfatases" |
| 9:33 am - 10:01 am | Susan Bellis (University of Alabama-Birmingham)
"ST6Gal I-mediated sialylation of beta1 integrins may contribute to colon carcinoma by regulating tumor cell adhesion and motility" |
| 10:01 am - 10:16 am | Olga Kovbasnjuk (Johns Hopkins Medical School)
"Glycosphingolipid Gb3 in colon cancer cells metastatic transformation" |
| 10:16 am - 10:30 am | Paula Cabrera (UCLA)
"A novel role for the C2GnTI as a tumor suppressor in T cell lymphoma" |
| 10:30 am - 11:00 am | COFFEE BREAK |
| 11:00 am - 11:30 am | Jeff Esko (UCSD)
"Glycan targets for chemotherapy" |
| 11:30 am - 12:00 pm | Michael A. Hollingsworth (University of Nebraska)
"Mucins and the pathogenesis of pancreatic cancer" |
| 12:00 pm - 12:15 pm | Lubor Borsig (University of Zurich)
"The L-selectin-mediated contribution of leukocytes to metastasis" |
| 12:15 pm - 12:30 pm | Isabelle Camby (Universite Libre de Bruxelles)
"Galectin-1 knocking-down in human U87 glioblastoma cells impairs invasion and alters pattern of gene expression" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session / Refreshments |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GLYCOBIOLOGY OF MICROBES AND PARASITES |
| Discussion Leader: Phil Robbins (Boston University) |
| 7:30 pm - 7:35 pm | Phil Robbins (Boston University)
Introduction |
| 7:35 pm - 8:04 pm | John Samuelson (Boston University)
"Topics in the evolution of N-linked glycosylation" |
| 8:04 pm - 8:33 pm | Chris Raetz (Duke University)
"Saccharolipids of gram-negative bacteria" |
| 8:33 pm - 9:02 pm | Tamara Doering (Washington University, St. Louis)
"A yeast under cover: the capsule of Cryptococcus neoformans" |
| 9:02 pm - 9:16 pm | Donald Harn (Harvard University)
"Pathogens and autologous cells induce immunosuppression via Lewis sugars" |
| 9:16 pm - 9:30 pm | Mario Feldman (Swiss Federal Institute of Technology)
"Engineering diverse N-linked glycosylation in Escherichia coli" |
| 9:30 pm - 11:00 pm | Refreshments / Posters |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ROLE OF GLYCOSYLATION IN PROTEIN FOLDING AND QUALITY CONTROL |
| Discussion Leader: Annette Herscovics (McGill University) |
| 9:00 am - 9:05 am | Annette Herscovics (McGill University)
Introduction |
| 9:05 am - 9:33 am | Ari Helenius (Zurich)
"The calnexin/calreticulin cycle: In and out, on and off" |
| 9:33 am - 10:01 am | Richard Sifers (Baylor College of Medicine)
"ER mannosidase I: a post-translational ambassador for eukaryotic genome expression" |
| 10:01 am - 10:16 am | Yuko Natsuka (Kyoto University)
"Functional analysis of EDEM homologue proteins" |
| 10:16 am - 10:30 am | Anant Menon (University of Wisconson)
"Flip-flop of GPI's across the ER" |
| 10:30 am - 11:00 am | COFFEE BREAK |
| 11:00 am - 11:30 am | Richard Cummings (University of Oklahoma)
"Chaperones make life sweeter: Cosmc and the T-synthase partnership for O-glycan biosynthesis" |
| 11:30 am - 12:00 pm | Tetsuya Okajima (Rutgers University)
"Chaperone activity of protein O-fucosyltransferase 1 within the endoplasmic reticulum promotes folding of the Notch receptor" |
| 12:00 pm - 12:15 pm | Christian Frank (University of Wisconson-Madison)
"Membrane topology of Rft1p, the putative Man5GlcNAc2-PP-Dol flippase" |
| 12:15 pm - 12:30 pm | Armando Parodi (Fundacion Instituto Leloir)
"Reappraisal of the role of nucleoside diphosphatases on yeast N- and O-glycosylation" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session / Refreshments |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ROLE OF GLYCOCONJUGATES IN SIGNAL TRANSDUCTION |
| Discussion Leader: Gerald W. Hart (Johns Hopkins) |
| 7:30 pm - 7:35 pm | Gerald W. Hart (Johns Hopkins)
Introduction |
| 7:35 pm - 8:04 pm | Jeffrey Kudlow (University of Alabama-Birmingham)
"The removal of O-GlcNAc is required to de-repress estrogen-response genes" |
| 8:04 pm - 8:33 pm | Naoyuki Taniguchi (Osaka University)
"Fut 8 KO mice cause the lung emphysema due to signaling disorder" |
| 8:33 pm - 9:02 pm | James Dennis (University of Toronto)
"Co-regulation of hexosamine, protein glycosylation and cytokine signaling; affects on aging" |
| 9:02 pm - 9:16 pm | Neil Olszewski (University of Minnesota)
"Investigating the role of O-GlcNAc modification of plant proteins" |
| 9:16 pm - 9:30 pm | Alexandra Nita-Lazar (Stony Brook University)
"Studies on the role of O-glucosylation in Notch signaling" |
| 9:30 pm - 11:00 pm | Refreshments / Posters |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:30 am | GLYCOBIOLOGY OF THE IMMUNE SYSTEM |
| Discussion Leader: Linda Baum (UCLA) |
| 9:00 am - 9:05 am | Linda Baum (UCLA)
Introduction |
| 9:05 am - 9:33 am | John Lowe (University of Michigan)
"Fucosylation-dependent control of lymphopoiesis" |
| 9:33 am - 10:01 am | Gary Clark (Eastern Virginia Medical School)
"The immune-reproductive nexus: The key to understanding many persistent pathological states in humans?" |
| 10:01 am - 10:16 am | Irma Van Die (VU Medical Center, Amsterdam)
"Regulation of FUT-I expression controls binding of DC-SIGN to ICAM-2 on human umbilical vein endothelial cells" |
| 10:16 am - 10:30 am | Emerson Bernardes (University of Sao Paulo)
"Toxoplasma gondii infection reveals a dual role of galectin-3 on innate and adaptive immune response" |
| 10:30 am - 11:00 am | COFFEE BREAK |
| 11:00 am - 12:30 pm | NEURONAL GLYCOBIOLOGY |
| Discussion Leader: Jacques Baenziger (Washington University) |
| 11:00 am - 11:05 am | Jacques Baenziger (Washington University)
Introduction |
| 11:05 am - 11:33 am | Minoru Fukuda (Burnham Institute)
"Loss of polysialic acid impairs neural development in ST8Sia-II and ST8Sia-IV double knockout mice" |
| 11:33 am - 12:01 pm | Mike Tiemeyer (University of Georgia)
"Taking the Toll road to tissue-specific glycan expression" |
| 12:01 pm - 12:16 pm | Karen Colley (University of Illinois-Chicago)
"Polysialyltransferase recognition and polysialylation of NCAM" |
| 12:16 pm - 12:30 pm | Yasuhiro Hashimoto (RIKEN)
"Sialylation enhances the secretion of APP" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session / Refreshments |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BIOSYNTHESIS OF GLYCOCONJUGATES |
| Discussion Leader: Harry Schachter (Toronto) |
| 7:30 pm - 7:35 pm | Harry Schachter (Toronto)
Introduction |
| 7:35 pm - 8:04 pm | Tom Gerken (Case Western)
"Understanding protein O-glycosylation and biosynthesis: Approaches for characterizing transferase peptide substrate specificity" |
| 8:04 pm - 8:33 pm | Raffi Aroian (UCSD)
"The glycobiology of bacterial toxin - host interactions in C. elegans" |
| 8:33 pm - 9:02 pm | Vlad Panin (Texan A&M)
"Drosophila sialyltransferase: Biochemical characterization and potential developmental functions" |
| 9:02 pm - 9:16 pm | Chris West (University of Oklahoma)
"Prolyl hydroxylation, glycosylation and oxygen sensing in Dictyostelium" |
| 9:16 pm - 9:30 pm | Tomoya Akama (Burnham Institute)
"Enzymatic activity of alpha-mannosidase IIx in N-glycan biosynthesis" |
| 9:30 pm - 11:00 pm | Refreshments / Posters |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 10:30 am | STRUCTURAL AND CHEMICAL GLYCOBIOLOGY |
| Discussion Leader: Carlos Hirschberg (Boston University) |
| 9:00 am - 9:05 am | Carlos Hirschberg (Boston University)
Introduction |
| 9:05 am - 9:33 am | Geert-Jan Boons (University of Georgia)
"Telling glycosidase inhibitors what to do" |
| 9:33 am - 10:01 am | Stephen V. Evans (University of Victoria)
"Structure-function studies of the human ABO(H) blood group A and B glycosyltransferases" |
| 10:01 am - 10:16 am | Rachel Chen (Georgia Institute of Technology)
"Metabolic engineering for oligosaccharide synthesis" |
| 10:16 am - 10:30 am | Ram Vishwakarma (National Institute of Immunology, India)
"New chemical synthesis of full-length GPI molecules of parasitic protozoa: Preparation of novel fluorescent and deoxy-GPI probes and their application in biosynthetic and trans-bilayer distribution" |
| 10:30 am - 11:00 am | COFFEE BREAK |
| 11:00 am - 12:30 pm | GENOMICS, PROTEOMICS, AND GLYCOMICS |
| Discussion Leader: Anne Dell (Imperial College, London) |
| 11:00 am - 11:05 am | Anne Dell (Imperial College, London)
Introduction |
| 11:05 am - 11:33 am | Jim Paulson (Scripps)
"Decoding the glycome one glycan binding protein at a time" |
| 11:33 am - 12:01 pm | Kurt Drickamer (Oxford University)
"Biological implications of receptor genomics and ligand glycomics" |
| 12:01 pm - 12:16 pm | Alison Nairn (University of Georgia)
"Quantitative real-time PCR method analysis of transcript abundance for glycosyltransferase genes in mouse tissues and embryonic stem cells" |
| 12:16 pm - 12:30 pm | Albena Samokovlisky (Procognia)
"Glycoanalysis on lectin arrays" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session / Refreshments |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GLYCOBIOLOGY OF HUMAN GENETIC DISEASES |
| Discussion Leader: Hudson Freeze (Burnham Institute) |
| 7:30 pm - 7:35 pm | Hudson Freeze (Burnham Institute)
Introduction |
| 7:35 pm - 8:04 pm | Daniel Michele (Universtiy of Michigan)
"Targeting dystroglycan function in muscular dystrophies" |
| 8:04 pm - 8:33 pm | Tamao Endo (Tokyo)
"Initiation of O-mannosylation and congenital muscular dystrophy" |
| 8:33 pm - 9:02 pm | Thiery Hennet (University of Zurich)
"Cellular responses to glycosylation defects in CDG" |
| 9:02 pm - 9:16 pm | Lars Bode (Burnham Institute)
"Proposed molecular mechanisms of protein-losing enteropathy" |
| 9:16 pm - 9:30 pm | Richard Steet (Washington University)
"COG-7 deficient fibroblasts (CDG-IIf) are impaired in Golgi to ER retrograde trafficking" |
| 9:30 pm - 10:00 pm | BUSINESS MEETING |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
