Session 1 |
Sunday PM - January 9 |
Isotopic Anthropology |
--discussion leader John S. Vogel, Lawrence Livermore Laboratory |
7:30 |
Richard P. Evershed, University of Bristol UK -- Anthropogenic Signals Preserved in Compound Specific Stable Isotope Values |
8:10 |
Beverly Johnson, University of Washington, Seattle -- Isotopic History of Vegetation Changes in Australia |
8:50 |
Julia A. Lee-Thorp, University of Cape Town, Republic of South Africa -- Isotopic Analysis of Diet in Hominids 3-Million Years Ago |
Session 1 |
Monday AM - January 10 |
Hydrogen Bonding in Chemical and Enzymatic Systems |
--discussion leader William W. (Mo) Cleland, University of Wisconsin |
9:00 |
Ann E. McDermott, Columbia University, New York -- NMR Studies of Enzyme Active Sites |
10:00 |
CONFERENCE PHOTO |
10:30 |
Coffee |
11:00 |
Charles L. Perrin, University of California, San Diego -- Symmetry of Hydrogen Bonds in Solution: Single and Double-Well Potentials? |
11:45 |
Albert S. Mildvan, Johns Hopkins University, Baltimore -- NMR Studies of LBHBs on Enzymes |
Session 3 |
Monday PM - January 10 |
Enzymatic Mechanisms Probed by Isotope Effects |
--discussion leader - Richard Schowen, University of Kansas, Lawrence |
7:30 |
John Blanchard, Albert Einstein College of Medicine, Bronx -- Isotopic
& Mechanistic Probes of Amino Acid Racemization |
8:10 |
James W. Whittaker, Oregon Graduate Institute, Portland -- Isotopic Analysis of Radical Copper Oxidases |
8:50 |
Amnon Kohen, University of Iowa, Iowa City -- Enzyme Dynamics and Hydrogen Tunneling in a Thermophilic Alcohol Dehydrogenase |
Session 4 |
Tuesday AM January 11 |
Computational Chemistry and Isotope Effects |
--discussion leader - Steven Schwartz, Albert Einstein College of Medicine, Bronx |
9:00 |
Thomas C. Bruice, University of California, Santa Barbara -- Ground State Near Approach Conformations and Transition State Structures in Enzymatic Reactions |
9:45 |
Jiali Gao, SUNY Buffalo, Buffalo -- Electrostatic Stress in Enzyme Catalysis: The Structure and Mechanism of Orotidine 5'-monophosphate Decarboxylase (ODCase) |
10:30 |
Coffee |
11:00 |
Paul J. Berti, McMaster University, Hamilton -- Determining transition states from KIEs: Structure interpolation, unified models, and quantum chemistry |
11:45 |
Selected short presentations from the Mon-Tue poster session |
Session 5 |
Tuesday PM - January 11 |
Isotopes in Chemistry |
--discussion leader - Poul Erik Hansen, Roskilde University, Denmark |
7:30 |
Atsuyoshi Ohno, Fukui University of Technology, Japan - Stereochemical Isotope Effects in Electron Transfer Complexes |
8:10 |
Olle Matsson, Uppsala, Sweden - Isotope Effects with Exotic Nuclei |
8:50 |
R. Stanley Brown, Queen's University, Ontario - Transition States in Halogen Transfer Reactions |
Session 6 |
Wednesday AM January 12 |
Methods in Isotopic Fractionations |
--discussion leader - Vernon Anderson, Case Western Reserve University, Cleveland |
9:00 |
Michael Toney, University of California, Davis -- Direct Determination of Kinetic Isotope Effects by Continuous-Flow Analysis |
9:45 |
Jane Dyson, Scripps Institute, La Jolla -- Protein Folding of Apomyoglobin by Solvent Deuterium Exchange and NMR |
10:30 |
Coffee |
11:00 |
Dexter Northrop, University of Wisconsin, Madison -- Pressure Dependence of Isotope Effects as a Means of Separating and Identifying Multiple Origins |
11:45 |
Alan G. Marshall, Florida State University, Tallahassee -- Isotopic Amplification and Exchange as MS probes of Biomacromolecular Structure and Mapping of Contact Surfaces |
Session 7 |
Wednesday PM - January 12 |
Theory for Isotope Effects |
--discussion leader - Judith Klinman, University of California, Berkeley |
7:30 |
Hans Heinrich Limbach, Freie Universität Berlin -- Isotope Effects and NMR Properties of Short Hydrogen Bonds |
8:10 |
Donald Truhlar, University of Minnesota, Minneapolis -- Dynamics Analysis for Predicting KIE in Chemistry and Enzymology |
8:50 |
James T. Hynes, University of Colorado at Boulder -- A Nontraditional Theory of Kinetic Isotope Effects for Proton Transfer Reactions in Polar Environments |
Session 8 |
Thursday AM - January 13 |
Transition States |
--discussion leader - Ildiko Kovach, Catholic University of America, Washington, D.C. |
9:00 |
Daniel Quinn, University of Iowa, Iowa City -- Transition State Structural Analysis for Acetylcholinesterase |
9:45 |
Andrew Bennet, Simon Fraser University, Burnaby -- Kinetic Isotope Effects as Probes of Sulfur and Oxygen-Stabilized Cations |
10:30 |
Coffee |
11:00 |
Phil Huskey, Rutgers University, Newark -- Transition States for Decarboxylations: Carbon Isotope Effects |
11:45 |
Selected short presentations from the Wed-Thur poster session |
Session 9 |
Thursday PM - January 13 |
Atmospheric and Extraterrestrial Chemistry |
--discussion leader - Takanobu Ishida, SUNY Stony Brook |
7:30 |
Edward C. Zipf, University of Pittsburgh, Pittsburgh -- Isotopes in the Precambrian Epoch and the Emergence of Life |
8:10 |
Juergen Guenther, Max Planck Institut fuer Kernphysik (MPIK) -- Ozone Isotopes in the Atmosphere: Implications from Laboratory Studies |
8:50 |
Martin Saunders, Yale University, New Haven -- Helium Isotope Ratios in Extraterrestrial Fullerenes |