SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
5:00 pm | Reception (Poster Room) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Opening of the Conference |
| Nancy Ryan Gray, Director, Gordon Research Conferences
Opening Comments |
| Jacob Bigeleisen (Chair, First GRC on Isotopes, 1954)
Introduction to the 50th Anniversary Session |
7:40 pm - 9:30 pm | Isotopic Information in Atmospheric Chemistry |
| Discussion Leader: Max Wolfsberg (University of California, Irvine) |
7:40 pm - 8:15 pm | F. Sherwood Rowland (University of California, Irvine)
"Some Isotopic Applications in Atmospheric Chemistry" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 9:00 pm | Jeffrey Severinghaus (Scripps Institution of Oceanography)
"History of climate from gas isotope fractionation by thermal diffusion in air bubbles trapped in glacial ice" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Kristie Boering (University of California, Berkeley) "Unusual Kinetic Isotope Effects, Greenhouse Gases, and Climate: From the Molecular to the Global State" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Elucidation of Organic Reaction Mechanisms by Kinetic Isotope Effects |
| Discussion Leader: Jerry Kresge (University of Toronto) |
9:00 am - 9:35 am | John Richard (SUNY at Buffalo)
"Primary Kinetic Isotope Effects and Intrinsic Reaction Barriers for Proton Transfer at Carbon" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:25 am | Group Photo and Coffee Break |
10:25 am - 11:00 am | Dan Singleton (Texas A&M)
"Dynamic Selectivity and Isotope Effects in Ordinary Organic Reactions in Solution" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:50 am | Vernon Parker (Utah State University)
"Consecutive Transition States on the Reaction Coordinates for C-H Proton and Hydride Transfer Reactions. Apparent and Real Deuterium Kinetic Isotope Effects" |
11:50 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | John Thoburn (Randolph-Macon College) "Quantum Dynamics of [1,7] Hydrogen Shift in 1,3,5-Heptatrienes: Implications for Kinetic Isotope Effects and Swain-Schaad Exponents" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Hydrogen-Bonding: Advances in Structure and Dynamics |
| Discussion Leader: Charles L. Perrin (University of California San Diego) |
7:30 pm - 8:05 pm | Dan O'Leary (Pomona College)
"Deuterium and Tritium NMR Equilibrium Isotope Effects Involving OH/OH and CH/N Hydrogen Bonds: Applications in Conformational and Configurational Analysis" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:55 pm | Hans Heinrich Limbach (Free University Berlin)
"Hydrogen Bond Isotope Effects studied by NMR" |
8:55 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Sosale Chandrasekhar (Indian Institute of Science) "Isotope Effects on Hydrogen Bonding: Implications for the Theory of Primary Kinetic Isotope Effects" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Probing Inorganic Reactions with Kinetic Isotope Effects |
| Discussion Leader: James Mayer (University of Washington) |
9:00 am - 9:35 am | Michael Heinekey (University of Washington)
"Structural Isotope Effects in Transition Metal Dihydrogen Complexes" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Klaus Theopold (University of Delaware) "Hydrogen Atom Tunneling in C-H Activation by Metal Oxo Complexes" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:20 am | William D. Jones (University of Rochester)
"Isotope Effects in C-H Bond Activation Reactions by Transition Metals" |
11:20 am - 11:35 am | Discussion |
11:35 am - 12:10 pm | David M. Kramer (Washington State University)
"Proton-coupled electron transfer during hydroquinone oxidation at
cytochrome bc1 and b6f complexes and in biomimetic systems" |
12:10 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Thermodynamics of Isotope Effects in Solutions, including Polymer Solutions |
| Discussion Leader: Alexander Van Hook (University of Tennessee)
|
7:30 pm - 8:05 pm | Luis Rebelo (New University of Lisbon)
"Esoteric isotope effects on the thermodynamics of 'simple' and 'not-so-simple' systems. A view from the shore." |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Johannes Messinger (Max Planck Institute for Bioinorganic Chemistry) "Analyzing the Mechanism of Photosynthetic Water Oxidation Using Time-Resolved Isotope Ratio Mass Spectrometry" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:30 pm | Jacob Bigeleisen (SUNY Stony Brook)
Jack Shiner (Indiana University)
Max Wolfsberg (University of California Irvine)
"Origins of the Gordon Conference on Isotopes" Panel Discussion |
9:30 pm - | Discussion and Refreshments |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Advances in Enzyme Catalyzed Reactions |
| Discussion Leader: Piotr Paneth (Technical University of Lodz) |
9:00 am - 9:35 am | Justine Roth (Johns Hopkins)
"Oxygen-18 kinetic isotope effects on O2 activation reactions" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Patrick Frantom (Texas A&M University) "Uncoupled Mutant Forms of Tyrosine Hydroxylase Unmask Deuterium Secondary and Solvent Isotope Effects" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:20 am | W. Wallace Cleland (University of Wisconsin)
"The Use of Isotope Effects to Determine Enzyme Mechanisms" |
11:20 am - 10:35 am | Discussion |
11:35 am - 12:10 pm | Wilfred van der Donk (University of Illinois)
"An unusual isotope effect on substrate inhibition in lipoxygenase" |
12:10 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Theoretical Approaches to the Interpretation of Isotope Effects |
| Discussion Leader: Zorka Smedarchina (NRC of Canada) |
7:30 pm - 8:05 pm | Don Truhlar (University of Minnesota)
"Variational transition state theory with multidimensional tunneling calculations for the calculation of kinetic isotope effects" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:55 pm | Willem Siebrand (NRC of Canada)
"Enzymatic CH-bond cleavage: An isotopic perspective" |
8:55 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Sonja Braun-Sand (University of Southern California) "Validation of Simplified Models for Studies of Proton Translocations in Biological Systems" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Hydrogen Tunneling: Linking Catalysis to Motion and Dynamics |
| Discussion Leader: Judith Klinman (University of California Berkeley) |
9:00 am - 9:35 am | Steve Schwartz (A. Einstein College of Medicine)
"Kinetic Isotope Effects in Coupled Electron Proton Transfer Reactions - what can we learn from models?" |
9:35 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Amnon Kohen (University of Iowa) "Environmentally Coupled Tunneling in Enzymatic Hydride Transfer Reactions" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:20 am | Richard G. Finke (Colorado State University)
"A New, Coenzyme B12 Experimental Test of the Enzyme-Enhanced H-Tunneling Hypothesis" |
11:20 am - 11:35 am | Discussion |
11:35 am - 12:10 pm | Sharon Hammes-Schiffer (Pennsylvania State University)
"Hydrogen Tunneling and Protein Motion in Enzyme Reactions" |
12:10 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Advances in Protein Dynamics using Isotopic Probes |
| Discussion Leader: Al Mildvan (Johns Hopkins University) |
7:30 pm - 8:05 pm | Dorothee Kern (Brandeis University)
"Enzymes in Action - Protein Dynamics During Catalysis and Signaling" |
8:05 pm - 8:20 pm | Discussion |
8:20 pm - 8:55 pm | Richard Armstrong (Vanderbilt)
"Evaluation of Enzyme Structure and Dynamics with Amide H/D Exchange Mass Spectrometry" |
8:55 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | William Bachovchin (Tufts University) "Active Site H-Bonds, Histidine Ring Dynamics and the Catalytic Mechanism of Serine Proteases" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |