SUNDAY |
2:00 PM - 9:00 PM | Arrival & Reception |
5:00 PM - 6:00 PM | Welcome Reception |
6:00 PM | Dinner |
7:30 PM - 9:30 PM | Application of Genomics & Proteomics to Toxicology |
| Chair: Alan Buckpitt
Co-Chair/Discussion Leader: Hisham Hamadeh |
7:30 PM - 8:10 PM | Jeffrey F. Waring Developing a Gene Expression Compendium for Predicting and Defining Toxic Responses |
8:10 PM - 8:50 PM | Daniel Liebler Analysis of Protein Modifications and Proteomic Diversity by LC-MS |
8:50 PM - 9:30 PM | Mike Snyder Global Screening of Proteomes Using Protein Chips |
MONDAY |
7:30 AM - 8:30 AM | Breakfast |
9:00 AM - 12:30 PM | Role of the Extracellular Matrix in Mediating the Toxic Response |
| Chair: Lynn Allen-Hoffman
Co-Chair/Discussion Leader: Randall J. Ruch |
9:00 AM - 9:50 AM | Jeffrey W. Smith A Redox Site in the Extracellular Face of Integrin: A Link Between Oxidative Stress and Cell Adhesion |
9:50 AM - 10:40 AM | Alan Parrish Selective Loss of N and Ksp Cadherin in Mercuric Chloride-Induced Acute Renal Failure |
10:40 AM - 11:00 AM | Break |
11:00 AM - 11:50 AM | Nader Sheibani PECAM-1 and Endothelial Cell Adhesive Mechanisms: Potenial Targets for Toxicity |
11:50 AM - 12:30 PM | Late Breaking Research Presentations |
| Chairs: Hisham Hamadah and Randall J. Ruch |
11:50 AM - 12:10 PM | Robert Gerwien A predictive toxicogenomics screen (PTS) for the triage of potential therapeutics |
12:10 PM - 12:30 PM | Randall J. Ruch Positive transcriptional regulation of Connexin32 by Hepatocyte Nuclear Factor-1 |
12:30 PM - 1:30 PM | Lunch |
1:30 PM - 4:00 PM | Afternoon activities and Informal Gatherings (No Meetings) |
4:00 PM - 6:00 PM | Poster Session I
Chairs: Jerry Heindel and Colin Jefcoate |
6:00 PM | Dinner |
7:30 PM - 9:30 PM | Cell Cycle Control and Signaling in Toxicity |
| Chair: Serrine Lau
Co-Chair/Discussion Leader: Terry Monks |
7:30 PM - 8:10 PM | David Johnson E2F1 Signaling to p53 Via the ATM Kinase |
8:10 PM - 8:50 PM | Jennifer A. Pietenpol p53 Signaling and the Cellular Response to Stress |
8:50 PM - 9:30 PM | Adrian Senderowicz Preclincal and Clinical Development of Cyclin-Dependent Kinase Inhibitors for Cancer Therapy |
TUESDAY |
7:30 AM - 8:30 AM | Breakfast |
9:00 AM - 12:30 PM | Receptor-Mediated Toxicity |
| Chair: Cornelius Elferink
Co-Chair/Discussion Leader: Michael Gallo |
9:00 AM - 9:50 AM | Josef Abel Regulation of Ah-Receptor Expression and its Modulation by Cytokines |
9:50 AM - 10:40 AM | Edward Leof Coupled Endocytic and Signaling Activity of TGF-beta Receptor Complexes |
10:40 AM - 11:00 AM | Break |
11:00 AM - 11:50 AM | Anita Roberts New Twists on a Simple Signaling Pathway: TGF-beta and Smads |
11:50 AM - 12:30 PM | Late Breaking Research Presentations |
| Chairs: Terry Monks and Michael Gallo |
11:50 AM - 12:10 PM | Mary Beth Genter Genomic analysis of Alachlor-induced oncogenesis in rat olfactory mucosa |
12:10 PM - 12:30 PM | Harihara Mehendale Activation of PPARV: a protective mechanism against acetaminophen hepatotoxicity in diabetes |
12:30 PM - 1:30 PM | Lunch |
1:30 PM - 6:00 PM | Afternoon activities and Informal Gatherings (No Meetings) |
6:00 PM | Dinner |
7:30 PM - 9:30 PM | Redox-Regulated Transcriptional Control |
| Chair: Ken Ramos
Co-Chair/Discussion Leader: Anil Jaiswal |
7:30 PM - 8:10 PM | Monica Montano Regulation of Quinone Reductase by the Estrogen Receptor: Molecular Mechanism and Functional Relevance to Breast Cancer |
8:10 PM - 8:50 PM | Bharat Aggarwal Nuclear Transcription Factor NF-kB as a Target for Oxidative Stress and Inflammation |
8:50 PM - 9:30 PM | Nancy Colburn Molecular Targets for Cancer Prevention: AP-1 and Pdcd4 |
WEDNESDAY |
7:30 AM - 8:30 AM | Breakfast |
9:00 AM - 12:30 PM | Session VI: Molecular Mechanisms of Developmental Toxicity |
| Chair: Richard Finnell
Co-Chair/Discussion Leader: Ed Lammer |
9:00 AM - 9:50 AM | Erik Meyers FGF Signaling and Neural Tube Closure |
9:50 AM - 10:40 AM | William Skarnes Gene Trap Mutagenesis: Functional Analysis of Genes Required for Normal Mouse Development |
10:40 AM - 11:00 AM | Break |
11:00 AM - 11:50 AM | Gary Shaw Interactions Between Host Susceptibilities and Exogenous Exposures in Birth Defects Research: An Epidemiologic Perspective |
11:50 AM - 12:30 PM | Late Breaking Research Presentations |
| Chairs: Anil Jaiswal and Ed Lammer |
11:50 AM - 12:10 PM | Huimin Jiang Zinc fingers 1, 5 and 6 of Mtf-1 are essential for its metalloregulatory function on chromatin templates in vivo |
12:10 PM - 12:30 PM | Mary K. Walker 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) inhibition of coronary vasculogenesis is rescued by exogenous vascular endothelial growth factor (VEGF) or CoCl2 |
12:30 PM - 1:30 PM | Lunch |
1:30 PM - 4:00 PM | Afternoon activities and Informal Gatherings (No Meetings) |
4:00 PM - 6:00 PM | Poster Session II
Chairs: Colin Jefcoate and Jerry Heindel |
6:00 PM | Dinner |
7:30 PM - 9:30 PM | Apoptosis as a Mechanism of Toxicity |
| Chair: Barbara Hales
Co-Chair/Discussion Leader: Philip Mirkes |
7:30 PM - 8:10 PM | Michael Hengartner Apoptotic Pathways in the Nematode C. elegans |
8:10 PM - 8:50 PM | Eric H. Baehrecke Steroid Regulation of Programmed Cell Death During Drosophila Development |
8:50 PM - 9:30 PM | Zhengui Xia Mechanisms of Toxicant-Induced Apoptosis in CNS Neurons |
THURSDAY |
7:30 AM - 8:30 AM | Breakfast |
9:00 AM - 12:30 PM | Genetic Susceptibility to Toxicants |
| Chair: Gail McCarver
Co-Chair/Discussion Leader: Steven Leeder |
9:00 AM - 9:50 AM | Xifeng Wu Genetic Modifiers of Risk for Tobacco-Related Cancers |
9:50 AM - 10:40 AM | Clement E. Furlong The most appropriate approaches for evaluating paraoxonase (PON1) status in case/control or risk assessment studies |
10:40 AM - 11:00 AM | Break |
11:00 AM - 11:50 AM | Charlene McQueen Expression of N-Acetyltransferases: Risks and Benefits |
11:50 AM - 12:30 PM | Late Breaking Research Presentations |
| Chairs: Philip Mirkes and Steven Leeder |
11:50 AM - 12:10 PM | Rebecca Persinger Rotenone and/or chlorpyrifos exposure of human dopaminergic neroblastoma cells (SH-SY5Y) and cortical neurons induces activation of c-jun N-terminal kinase (jnk) and p38 MapK, mitochondrial translocation of Bax, and apoptosis |
12:10 PM - 12:30 PM | Wei Wang Role of Sp1 elements and promoter polymorphism in regulation of gene encoding human NRH:quinone oxidoreductase 2 |
12:30 PM - 1:30 PM | Lunch |
1:30 PM - 6:00 PM | Afternoon activities and Informal Gatherings (No Meetings) |
6:00 PM | Dinner |
7:30 PM - 8:30 PM | Keynote Address |
| Chair: Ronald N. Hines |
7:30 PM | Bruce Hammock From Butterflies to Blood Pressure: Epoxide Hydrolase as a Possible Therapeutic Target |
8:30 PM | Closing Evening Social |