| SUNDAY |
| 4:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CYTOSKELETAL ELEMENTS AND THEIR DYNAMICS |
| Discussion leader: James S. Clegg (UC Davis, CA, USA) |
| 19:25 | Coordinating cytoskeletal dynamics: interactions among microtubule, intermediate filament and actin cytoskeletons
Gregg G. Gundersen (Columbia University, New York, NY, USA) |
| 20:10 | Components and organization of the chloroplast division apparatus
Katherine W. Osteryoung (Michigan State University, East Lansing, MI, USA) |
| 20:55 | Actin organization and the coordination of cell signaling and actin dynamics
Laura M. Machesky (University of Birmingham, England, UK, EU) |
| General Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NEW IMPLICATIONS OF CLASSICAL COMPARTMENTATION |
| Discussion leader: John E. Wilson (Michigan State University, East Lansing, MI, USA) |
| 9:00 | Why do trypanosomes compartmentalize glycolysis? Answers from real and computer experimentation in cell biology
Barbara M. Bakker (BioCentrum Amsterdam [IMBS], NL, EU) |
| 9:45 | Rethinking mitochondrial structure
Carmen Mannella (Wadsworth Center, New York State Dept. of Health, Albany, NY, USA) |
| 10:30 | Coffee break |
| 10:55 | The mitochondrial permeability transition
Paolo Bernardi (U. Padova, Italy, EU) |
| 11:40 | Isoform sorting of microfilament components and the creation of intracellular compartments
Peter Gunning (University of Sydney, NSW, Australia) |
| 12:25 | General discussion |
| 12:45 pm | Group Photo / Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 8:10 pm | Paul A. Srere Memorial Session |
| Chair: Judit Ovadi (Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary) |
| 19:15 | Paul Srere: A life of metaboloney
G. Rickey Welch (University of Maryland, Baltimore County, MD, USA) |
| 19:25 | Paul Srere Memorial Lecture: What IS the cytosol?
James S. Clegg (University of California at Davis, CA, USA) |
| 8:10 pm - 9:30 pm | INTRACELLULAR ENVIRONMENT |
| Discussion leader: Judit Ovadi (Institute of Enzymology, Hungarian Academy of Sciences, Budapest, Hungary) |
| 20:10 | Effects of salts, solutes and hydration on biological processes
M. Thomas Record (University of Wisconsin, Madison, WI, USA) |
| 20:55 | Diffusion of solute and macromolecules in mammalian cell cytoplasm and organelles
Alan S. Verkman (University of California, San Francisco, CA, USA) |
| General Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | METHODS TO UNDERSTAND THE FUNCTIONING LIVING CELL |
| Discussion leader: Kevin M. Brindle (University of Cambridge, UK, EU) |
| 9:00 | The use of multi-photon methods to study macromolecular dynamics
Karsten König (Friedrich Schiller University, Jena, DE, EU) |
| 9:45 | Imaging biochemical reactions in cells
Philippe I.H. Bastiaens (EMBL, Heidelberg, DE, EU) |
| 10:30 | Coffee break |
| 10:55 | Native and designed fluorosensors as probes of protein interactions and gene expression
S.R. Adams (UC San Diego, CA, USA) |
| 11:40 | Detecting interactions and altered conformations of proteins in living cells
Nils Johnsson (Max-Delbrück-Laboratory, Köln, DE, EU) |
| 12:02 | Intracellular diffusion of low molecular weight solutes in muscle
Timothy S. Moerland (Florida State University, Tallahassee, FL, USA) |
| 12:24 | General Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROTEIN TRANSLATION AND DEGRADATION AND FOLDING |
| Discussion leader: Murray P. Deutscher (U Miami, FL, USA) |
| 19:15 | Mechanisms of chaperone-assisted protein folding: Effects of crowding agents
F. Ulrich Hartl (MPI Biochemie, Martinsried, DE, EU) |
| 20:00 | Quality control of membrane proteins by AAA proteases
Thomas Langer (Institut für Physiologische Chemie, München, DE, EU) |
| 20:45 | RNA/protein interactions in the signal recognition particle
Robert T. Batey (Yale University, New Haven, CT, USA) |
| General Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | SCAFFOLDING PROTEINS, SPATIAL AND TEMPORAL ASPECTS OF SIGNAL TRANSDUCTION |
| Discussion leader: Dennis Bray (U. Cambridge, UK, EU) |
| 9:00 | Multiprotein complexes in the regulation of signaling pathways in Arabidopsis
Daniel A. Chamovitz (Tel Aviv University, Tel Aviv, Israel) |
| 9:45 | Calcium waves and channels
Michael J. Berridge (The Babraham Institute, Cambridge, UK, EU) |
| 10:30 | Coffee break |
| 10:55 | Complex networks of signaling pathways
Ravi Iyengar (Mount Sinai School of Medicine, New York, NY, USA) |
| 11:40 | DISCUSSION FORUM on ULTRASENSITIVITY AND MACROMOLECULAR ORGANIZATION |
| María-Luz Cárdenas (Centre National de la Recherche Scientifique, Marseille, FR, EU), James Ferrell (Stanford University School of Medicine, Palo Alto, CA, USA) , Martin J. Kushmerick (University Washington Medical Center, Seattle, WA, USA) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ORGANIZATION OF GENE EXPRESSION |
| Discussion leader: Roel van Driel (BioCentrum Amsterdam [SILS], NL, EU) |
| 19:15 | The Assembly and Function of the Transcription Complex of E. coli depends on the Local Concentrations of Regulatory Proteins, which are Controlled (in part) by RNA Looping and Macromolecular Crowding
Peter H. von Hippel (University of Oregon, Eugene, OR, USA) |
| 20:00 | Chromatin Remodeling Machines
Bradley R. Cairns (Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA) |
| 20:45 | High resolution mapping of signaling components in the Fce RI pathway
Bridget S. Wilson (University of New Mexico School of Medicine, Albuquerque, NM, USA) |
| 21:07 | General discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHANNELING IN METABOLIC PATHWAYS |
| Discussion leader: Brenda Winkel-Shirley (Virginia Tech, Blacksburg, VA, USA) |
| 9:00 | The mechanism of substrate channeling in the bifunctional thymidylate synthase-dihydrofolate reductase
Karen S. Anderson (Yale University School of Medicine, New Haven, CT, USA) |
| 9:45 | Substrate channeling in the pyrimidine and arginine pathways in an archeon
Guy Hervé (Université Pierre et Marie Curie, Paris, FR, EU) |
| 10:30 | Coffee break |
| 10:55 | Metabolite channeling in the purine pathway
Joanne Stubbe (MIT, Cambridge, MA,USA) |
| 11:40 | Intracellular energetic units in muscle cells - a new look at old metabolic problems
Valdur Saks (National Institute of Chemical and Biological Physics, Tallinn, Estonia and Joseph Fourier University, Grenoble, FR, EU) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | FUNCTIONAL GENOMICS, PROTEOMICS |
| Discussion leader: Stephen G. Oliver (University of Manchester, UK, EU) |
| 19:30 | Functional genomics via the metabolome
Douglas B. Kell (University of Wales, Aberystwyth, Dyfed, UK, EU) |
| 20:15 | The use of mass spectrometry for the characterization of multiprotein complexes
Gitte Neubauer (EMBL, Heidelberg, DE, EU) |
| 21:00 | Learning protein function from structure, interactions, sequences and computer analyses
Antoine Danchin (Institut Pasteur, Paris, FR, EU) |
| 21:45 | General Discussion |
| 21:55 | Conference Closing remarks
Natalie S. Cohen (University of Southern California School of Pharmacy, Los Angeles, CA, USA) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
