| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | METABOLISM/REGULATION |
| Discussion Leader: Eugene Gerner (University of Arizona) |
| 7:30 pm - 8:10 pm | Tony Pegg (Pennsylvania State University)
"Overview of polyamine metabolism" |
| 8:10 pm - 8:50 pm | Emanuele Giordano (University of Bologna)
"Coordinate biochemical cross-talk among arginine-dependent enzymatic pathways in the hypertrophic heart" |
| 8:50 pm - 9:30 pm | Colin Hanfrey (Institute of Food Research, Norwich)
"Polyamines and translation initiation" |
| 9:30 pm | RECEPTION |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HOMEOSTASIS I (OXIDASES/TRANSPORT) |
| Discussion Leaders: Heather Wallace (University of Aberdeen) &
John Mitchell (Northern Illinois University) |
| 9:00 am - 9:40 am | Carl Porter (Roswell Park Cancer Institute)
"New insights into polyamine catabolism based on SMO and PAO" |
| 9:40 am - 10:20 am | Robert Casero (John Hopkins University School of Medicine)
"Polyamine catabolism, a matter of life and death" |
| 10:20 am | Coffee Break |
| 10:35 am - 11:15 am | Keiko Kashiwagi (Chiba University)
"Polyamine transport in eukaryotic and prokaryotic cells" |
| 11:15 am - 11:55 am | Flavio Flamigni (University of Bologna)
"Polyamine and signaling pathways in mammalian cells" |
| 12:15 pm | Group Photograph |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HOMEOSTASIS II (ANTIZYME) |
| Discussion Leader: John Atkins (University of Utah) |
| 7:30 pm - 8:10 pm | Tongwen Wang (Virginia Mason Research Institute)
"Antizyme-dependent degradation in BMP-mediated signaling pathways" |
| 8:10 pm - 8:50 pm | Senya Matsufuji (Jikei University School of Medicine)
"An upstream element for the antizyme frameshift signal" |
| 8:50 pm - 9:30 pm | Philip Coffino (University of California, San Francisco)
"ODC not busy being born is busy dying" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHROMATIN/GENE ACTIVATION |
| Discussion Leader: Olle Heby (Umea University) |
| 9:00 am - 9:40 am | Subhash Minocha (University of New Hampshire)
"Regulation of gene expression in relation to polyamine metabolism" |
| 9:40 am - 10:20 am | Andrew Maniotis (University of Illinois at Chicago)
"Unexpected differences among normal versus malignant cell DNA sequestration or exposure: targeting oncogene deregulation with polyamines" |
| 10:20 am - 10:35 am | Coffee Break |
| 10:35 am | Poster Session I Presentations |
| Discussion Leaders: Eugene Gerner (University of Arizona Health Science Center) & Tony Michael (Institute of Food Research, Norwich) |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session I (continued) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PARASITES |
| Discussion Leader: Nigel Yarlett (Pace University) |
| 7:30 pm - 8:10 pm | Sigrid Roberts (Oregon Health Sciences University)
"Polyamines in leishmania: elucidation of a pathway" |
| 8:10 pm - 8:50 pm | Marcos Vannier dos Santos (Electron Microscopy, Centro de Pesquisas Goncalo Moniz-FIOCRUZ, Bahia)
"Protozoal polyamines: cell organization and antioxidative protection" |
| 8:50 pm - 9:30 pm | Salim Merali (New York University School of Medicine)
"S-Adenosylmethionine, polyamines and Pneumocystis carinii" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | TRANSGENICS/CANCER |
| Discussion Leaders: Lisa Shantz (Pennsylvania State University) & Frank Berger (University of South Carolina) |
| 9:00 am - 9:40 am | Juhani Janne (University of Kuopio)
"Genetic engineering of polyamine catabolism in transgenic rats and mice" |
| 9:40 am - 10:20 am | John Cleveland (St. Jude Children's Research Hospital)
"Regulation and role of ODC in MYC-induced tumorigenesis" |
| 10:20 am - 10:35 am | Coffee Break |
| 10:35 am - 11:15 am | Debora Kramer (Roswell Park Cancer Institute)
"Activated polyamine catabolism and cancer prevention" |
| 11:15 am - 11:55 am | Tom O'Brien (Lankenau Medical Research Center)
"Anti-polyamine therapy of squamous cell carcinoma" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ENZYME STRUCTURE |
| Discussion Leader: Margaret Phillips (University of Texas Southwestern Medical Center) |
| 7:30 pm - 8:10 pm | Maria Bewley (Brookhaven National Laboratory)
"The role of protein turnover in the control of SSAT: a tale of two lysines" |
| 8:10 pm - 8:50 pm | Steve Ealick (Cornell University)
"Structural studies on polyamine biosynthetic enzymes" |
| 8:50 pm - 9:30 pm | Poster II Presentations |
| Discussion Leaders: E. Gerner, T. Michael |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NEW LEADS/CLINICAL ASPECTS |
| Discussion Leaders: Stina Oredsson (University of Lund) & Lawrence Marton (SLIL Biomedical) |
| 9:00 am - 9:40 am | Ben Frydman (SLIL Biomedical)
"Novel synthetic polyamine analogs which inhibit growth of cancer tumor xenografts in nude mice" |
| 9:40 am - 10:20 am | Elena Martinez (University of Arizona)
"Genetic variant in the ornithine decarboxylase gene and aspirin use suppress polyamine levels to reduce risk of colorectal neoplasia" |
| 10:20 am - 10:35 am | Coffee Break |
| 10:35 am - 11:15 am | Victor Levin (M.D. Anderson Cancer Center)
"Efficacy of DFMO with PVC in randomized phase III study of patients with anaplastic gliomas" |
| 11:15 am | Vote and Elections |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster II (continued) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | KEYNOTE ADDRESS |
| 7:30 pm | Seymour Cohen
"Some views on the past and present status of polyamine research" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
