(Sunday PM) | Membrane Protein Folding and Structure |
Discussion Leader: Steve White, U. California at Irvine
- Don Engelman, Yale U. - Membrane protein folding and design.
- Werner Kühlbrandt, Max Plank Institute Biophysics (Frankfurt) -2D crystallisation and structure of the plasma membrane proton pump.
- Lukas Tamm, U. Virginia - Folding of a ß-barrel membrane protein.
(Monday AM) | Pores and Channels |
Discussion Leader: Bill Cramer, Purdue U.
- Andreas Engel, Biozentrum U. (Basel) - Water channels: ancient proteins with a highly conserved core and variable hydrophilic surfaces.
- Eduardo Perozo, U. Virginia - Proton-dependent gating in the Streptomyces potassium channel.
- Hagan Bayley, Texas A & M - Pore engineering: tinkering with Staphylococcal α-hemolysin.
- Esther Nachliel, Tel Aviv U. - The structural response of proton-driven membrane proteins to vectorial proton flux.
(Monday PM) | Physics and Chemistry of Proton Transport |
Discussion Leader: Colin Wraight, U. Illinois
- Regis Pomes, Los Alamos National Laboratory - Theoretical studies of the molecular mechanism of proton translocation in membrane proteins.
- Hemi Gutman, Tel Aviv U. - The effect of intra-channel electrostatic profile on the dynamics of ion flux: studies with PhoE.
- David Silverman, U. Florida - Proton transfer through hydrogen-bonded water in catalysis by carbonic anhydrase.
(Tuesday AM) | Proton- and Sodium-Motive Fo |
Discussion Leader: Terry Krulwich, Mount Sinai School of Medicine
- Mark Girvin, Albert Einstein U. - Conformational changes related to proton translocation in subunit c of the ATP synthase.
- Masamitsu Futai, Osaka U. - Direct observation of rotation of c-oligomer of ATP synthase.
- Masasuke Yoshida, Tokyo Inst. Tech. - Rotation and catalysis of proton ATP synthase.
- Peter Dimroth, ETH (Zurich)- The sodium Fo motor of the ATP synthase from Propionigenium modestum.
- John Walker, MRC (Cambridge) - Generation of rotation in Fo and coupling to F1.
(Tuesday PM) | Biophysics of Rotary Motors |
Discussion Leader: Karlheinz Altendorf, U. Osnabrück
- Wolfgange Junge, U. Osnabrück - Enzyme mechanics in rotary proton ATP synthase
- George Oster, U. California at Berkeley - Mechanochemistry of ATP synthase.
- David Blair, U. Utah - Mutational and structural studies of the flagellar motor: implications for the mechanism of proton-driven rotation.
- Howard Berg, Harvard U. - Protons and the flagellar rotary motor.
(Wednesday AM) | Proton Transporting Cytochrome Oxidase |
Discussion Leaders: Shelagh Ferguson-Miller, Michigan State U. and Bob Gennis, U. Illinois
- Shinya Yoshikawa, Himeiji Inst. Tech. - A possible proton pumping mechanism of bovine heart cytochrome c oxidase.
- Shelagh Ferguson-Miller, Michigan State U. - Where is "outside" in cytochrome oxidase and how do protons get there?
- Bob Gennis, U. Illinois - The proton-conducting channels in cytochrome oxidase.
- Mårten Wikström, U. Helsinki - The proton-translocating mechanism of the heme-copper oxidases.
(Wednesday PM) | Halobacterial Rhodopsins |
Discussion Leader: John Spudich, U. Texas Medical School (Houston)
- Janos Lanyi, U. California at Irvine - X-ray diffraction structure of bacteriorhodopsin and its changes during proton transport.
- Sriram Subramanian, National Cancer Inst. - Structural basis of proton transport by bacteriorhodopsin.
- Tom Ebrey, U. Illinois - Pertubation of the pK's of key groups involved in light-induced proton release in bacteriorhodopsin.
(Thursday AM) | Electron Coupled Proton Transfer |
Discussion Leader: Peter Brezinski, U. Stockholm
- Mark Paddock, U. California at San Diego - Proton transfer pathways in bacterial reaction centers from Rb. sphaeroides.
- Marilyn Gunner, City Univ. of New York - Calculating the role of the protein in proton and electron transfers: examples from reaction centers and cytochrome c oxidase.
- Dan Nocera, Massachusetts Inst. Tech. - Proton-coupled electron transfer reactions: applications to small molecule activation.
- Anthony Crofts, U. Illinois - Protons processing by the bc1 complex
(Thursday PM) | Secondary Transport Carriers |
Discussion Leader: Shimon Schuldiner, Hebrew U. of Jerusalem
- Wil Konings, U. Groningen - MDR in Lactococcus lactis: a Dutch treat.
- Ernest Wright, U. Calif. at Los Angeles - Changes in symporter conformation cause coupling of sodium and sugar transport.
- Ron Kaback, U. Calif. at Los Angeles - Non-crystallographic approaches to membrane protein structure and function.
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