SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff and Conference Chair |
7:40 pm - 9:30 pm | ION CHANNELS |
| Session Chair: Tom DeCoursey (Rush University Medical Center) |
7:40 pm - 7:50 pm | Session Chair's remarks |
7:50 pm - 8:20 pm | Keynote Lecture: Chris Miller (Brandeis University) "Protons, chloride ions, channels, and antiporters - all mixed up" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Scott Ramsey (Virginia Commonwealth University) "H+ permeation in the voltage-gated proton channel Hv1" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Isaiah Arkin (Hebrew University, Israel) "Na+/H+ antiporters and viral ion channels: Experiment and simulations of H+-triggered devices" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | MEMBRANE-PROTEIN INTERACTIONS |
| Session Chair: Steve White (UC Irvine) |
| Discussion Leader: Tom Haines (Rockefeller University) |
9:00 am - 9:20 am | Session Chair's remarks |
9:20 am - 9:45 am | Janet Wood (University of Guelph, Canada) "Escherichia coli modulates the osmoregulatory response by placing transporter ProP in the cardiolipin-rich environment at the cell poles" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Bert Poolman (University of Groningen, The Netherlands) "Beyond bottlenecks in membrane protein production" |
10:15 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:45 am - 11:10 am | Antoinette Killian (Utrecht University, The Netherlands) "Membrane protein mimics: from single-span peptides to self-assembling oligomeric membrane proteins" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Short Presentation: Susanna Seppälä (Stockholm University, Sweden) "Dual topology membrane proteins" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Short Presentation: Dragan Popovic (City College, New York) "Proton pumping mechanism of cytochrome c oxidase: Electron-coupled proton transfer reactions" |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ACTIVE TRANSPORT ACROSS MEMBRANES |
| Session Chair: Roy Lancaster (Saarland University, Germany) |
| Discussion Leader: Qiang Cui (University of Wisconsin) |
7:30 pm - 7:40 pm | Session Chair's remarks |
7:40 pm - 8:05 pm | Uli Brandt (Frankfurt University, Germany) "Insights into the proton pumping machinery of mitochondrial complex I" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Sergei Balashov (UC Irvine) "Energy and proton transfer in xanthorhodopsin" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Ron Kaback (UC Los Angeles) "Lac Permease: how to stop worrying and learn to love anti-matter" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | CONTROL OF PROTON TRANSFER ACROSS MEMBRANES |
| Session Chair: Armen Mulkidjanian (University of Osnabrueck, Germany) |
| Discussion Leader: Alexei Stuchebrukhov (UC Davis) |
9:00 am - 9:10 am | Session Chair's remarks |
9:10 am - 9:35 am | Yasushi Okamura (Osaka University, Japan) "Does the fourth transmembrane segment (S4) contribute to proton permeation in voltage-gated proton channel?" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Joachim Heberle (Bielefeld University, Germany) "Voltage-controlled proton transfer in a membrane photoreceptor monitored by surface-enhanced IR difference spectroscopy" |
10:05 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:55 am | Bob Stroud (UC San Francisco) "Regulating water, glycerol and ammonia across membranes: QED" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Larry Pinto (Northwestern University) "How to inhibit the influenza A M2 proton channel" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Short presentation: TBA |
11:40 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MECHANISMS OF PROTON TRANSFER |
| Session Chair: Wolfgang Junge (University of Osnabrueck, Germany) |
| Discussion Leader: Simon de Vries (Delft University of Technology, The Netherlands) |
7:30 pm - 7:40 pm | Session Chair's remarks |
7:40 pm - 8:05 pm | Bertrand Garcia-Moreno (Johns Hopkins University) "Determinants of pKa values of internal ionizable groups in proteins" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Arieh Warshel (University of Southern California) "On the nature of proton transport in cytochrome c oxidase and other biological systems - what can be learned from consistent simulation studies" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Gerhard Hummer (NIH) "Gating mechanisms in proton pumping by cytochrome c oxidase" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | TRANSPORT THROUGH MEMBRANE PROTEINS |
| Session Chair: Norbert Dencher (Technische Universität Darmstadt, Germany) |
| Discussion Leader: Petra Hellwig (Universite Louis Pasteur, France) |
9:00 am - 9:10 am | Session Chair's remarks |
9:10 am - 9:35 am | Mark Sansom (University of Oxford, UK) "Coarse-grained simulations for membrane proteins: Applications to influenza M2 and related proteins" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Carola Hunte (University of Leeds, UK) "Tuning cytochrome bc1 complex activity" |
10:05 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:00 am | Bob Gennis (University of Illinois at Urbana-Champaign) "Lessons from the non-canonical heme-copper oxidases" |
11:00 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Michael Palmgren (University of Copenhagen, Denmark) "How protons are transported by the plasma membrane proton pump" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Short Presentation: Nicoleta Bondar (UC Irvine) "Opening the translocon: The role of hydrogen bonding" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | ELECTRON-PROTON COUPLING |
| Session Chair: Jon Hosler (University of Mississippi Medical Center) |
| Discussion Leader: Regis Pomes (Hospital for Sick Children, Toronto, Canada) |
7:30 pm - 7:40 pm | Session Chair's remarks |
7:40 pm - 8:05 pm | Shelagh Ferguson-Miller (Michigan State University) "Crystallographic evidence of structural changes in cytochrome oxidase induced by redox state and mutations in D and K proton channels" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Mårten Wikström (University of Helsinki, Finland) "Redox state-dependent control of proton transfer in cytochrome oxidase" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Sharon Hammes-Schiffer (Pennsylvania State University) "Proton-coupled electron transfer in enzymes: Hydrogen tunneling and protein motion" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ATP-COUPLED TRANSMEMBRANE TRANSPORT |
| Session Chair: Bob Fillingame (University of Wisconsin Medical School) |
| Discussion Leader: Jan Rydström (Göteborg University, Sweden) |
9:00 am - 9:10 am | Session Chair's remarks |
9:10 am - 9:35 am | John Walker (MRC Dunn Human Nutrition Unit, UK) "Mechanism of coupling and uncoupling the ATP synthase from proton-motive force" |
9:35 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Terry Krulwich (Mount Sinai School of Medicine) "Alkaliphile ATP synthase: Adaptations for both proton capture and retention" |
10:05 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Thomas Meier (Max-Planck-Institute of Biophysics, Frankfurt, Germany) "Switching gears in the Fo rotor ring from ATP synthases" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:20 am | Short presentation: TBA |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Short presentation: TBA |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PROTONS IN PROTEINS: SESSION IN MEMORY OF GEORG ZUNDEL |
| Session Chair: Colin Wraight (University of Illinois at Urbana-Champaign) |
| Discussion Leader: Ehud Pines (Ben-Gurion Univ. Negev) |
7:30 pm - 7:45 pm | Session Chair's remarks |
7:45 pm - 8:10 pm | Greg Voth (University of Utah) "The excess proton in aqueous and biomolecular systems: What have we learned since Eigen and Zundel" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Klaus Gerwert (Ruhr-Universität Bochum, Germany) "Proton transfer via protein bound water" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:10 pm | Hemi Gutman (Tel Aviv University, Israel) "The proton collecting antenna of bio-structures" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |