SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
4:30 pm - 6:00 pm | Reception |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote address |
| Henry Bourne (University of California, San Francisco) "Neutrophil Chemotaxis: Polarity and the Compass" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | G Proteins Regulators and Effectors I |
| Deborah Morrison (NCI/Frederick Cancer Research Center) "Regulation of The KSR MAPK Scaffold" |
| Michael Rosen* (University of Texas Southwestern Medical Center) "Contingent Phosphorylation/Dephosphorylation Provides a Mechanism of Molecular Memory in WASP" |
| Coffee Break and Group Photo |
| John Sondek (University of North Carolina at Chapel Hill)
"Activation of Rho GTPases by Dbl Family GEFs" |
| John Scott (Vollum Institute, Oregon)
"The Molecular Architecture of Signal Transduction Complexes" |
12:30 pm | Lunch |
4:00 pm - 6:00 pm | Posters / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | G Proteins Regulators and Effectors II |
| Jorge Galan (Yale University, School of Medicine)
"Actin, Ruffles, Vesicles and Salmonella" |
| Ed Manser* (Glaxo - Institute of Molecular and Cell Biology, Singapore)
"PAK Function and Regulation" |
| Wendell Lim (University of California, San Francisco)
"Scaffold Assembly Mechanisms" |
| Silvio Gutkind (National Institutes of Health)
"Crosstalk Between Rho GTPases and Heterotrimeric G Proteins" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Growth Control and Cell Cycle |
| Rick Assoian (University of Pennsylvania School of Medicine)
"Rho GTPases and G1 Phase Control" |
| Takeharu Nishimoto (Kyushu University, Japan)
"Ran and Cell-Cycle Check Point Control" |
| Michael White* (University of Texas Southwestern Medical Center)
"Molecular Linchpins in the Tumorigenic Platform" |
| Short talks |
12:30 pm | Lunch |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Oncogenesis |
| Channing Der (University of North Carolina at Chapel Hill)
"Contribution of Ras and Rho GTPases to Oncogenesis" |
| John Collard (The Netherlands Cancer Institute)
"Rho Proteins and Tumorigenicity" |
| Richard Marais (The Institute of Cancer Research, London)
"The Role of BRAF in Human Cancer" |
| A. Cox* (University of North Carolina at Chapel Hill)
"Targeting Rho Proteins For Anti Cancer Treatment" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Development |
| Linda Van Aelst* (Cold Spring Harbor Laboratory)
"Rap Signaling and Morphogensis" |
| Audrey Minden (Columbia University)
"The Rho GTPase Target PAK4; Roles in Cell Growth and Development" |
| Jonathan Chernoff (Fox Chase Cancer Center)
"Genetic Analysis of PAK Function" |
| Short talks |
12:30 pm | Lunch |
4:00 pm - 6:00 pm | Posters / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cell Adhesion |
| Benny Geiger (Weizmann Institute of Science, Israel)
"Molecular Dynamics of Extracellular Matrix-Cytoskeleton Interactions" |
| Martin Schwartz (University of Virginia)
"Regulation of Rac Membrane Targeting by Integrins" |
| Chris Marshall* (The Institute of Cancer Research, London)
"Interactions Between Small GTPases Signaling Pathways in Tumor Cell Invasion and Motility" |
| Crislyn D'Souza-Schorey (University of Notre Dame)
"Role of Membrane Traffic During Epithelial to Mesenchymal Transition" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell Migration |
| Richard Firtel (University of California, San Diego)
"Directional Sensing to Chemoattractants" |
| Victor Small (Austrian Academy of Sciences)
"Microtubules and cell Motility; Choosing Your Contacts" |
| Keith Burridge* (University of North Carolina at Chapel Hill)
"Reciprocal Signaling Between Cell Adhesion Molecules and Rho GTPases" |
| Keith Mostov (University of California, San Francisco)
"Morphogenesis of Multicellular Epithelial Structures" |
12:30 pm | Lunch |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cell Polarity |
| Anthony Bretscher (Cornell University)
"Microfilament Assembly and Cell Polarity" |
| Ian Macara (University of Virginia)
"Pars, Pals, Pins and Polarity" |
| Rong Li (Harvard Medical School)
"Signaling Through The Cytoskeleton: How Actin Synergizes With Cdc42 to Induce Cell Polarization in Yeast " |
| Shuh Narumiya* (Kyoto University School of Medicine, Japan)
"Rho Effectors in Cell Polarity; Function of Cdc42-mDia in Spindle Formation" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |