| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 4:30 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Signal transduction and cytoskeletal dynamics |
| Discussion leader: David Pellman |
| David Pellman (Harvard Medical School, U.S.A.)
Cell Cycle Regulation of Rho GTPases and Formins |
| Mike Rosen (University of Texas Southwestern Medical Center, U.S.A.)
Molecular Mechanisms of Actin Regulation by Formins |
| Fred Wittinghofer (Max Plank Institute, Germany)
Regulation of Formin Function by Rho Proteins |
| Tadaomi Takenawa (University of Tokyo, Japan)
Activation mechanism of WAVE family proteins |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Polarity and migration - I |
| Discussion leader: Alan Hall |
| Rick Firtel (University of California San Diego, U.S.A.)
Feedback loops mediated by Ras and Rac control leading edge formation |
| Alan Hall (University College London, England)
Rho GTPases and Cell Polarity |
| Alexander van Oudenaarde (Massachusetts Institute of Technology, U.S.A.)
Organization of travelling activity waves of the GTPase Cdc42 underlies dynamic cell polarization |
| 10:30 am - 11:00 am | Coffee Break / Photo (10:45 am) |
| Klaus Hahn (UNC Chapel Hill Medical School, U.S.A.)
Sensitive imaging of endogenous Rho family activity using novel fluorescent dyes-induction of motility |
| Zhenbiao Yang (University of California Riverside, U.S.A.)
Rho GTPase signaling to cytoskeletal dynamics in Arabidopsis |
| Short Talk: Stephen Lam (University of Illinois at Chicago. U.S.A.)
Role of Talin in Integrin Signaling |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session / Refreshments |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cell adhesion |
| Discussion leader: Yoshimi Takai |
| Johannes L. Bos (Unirsity Medical Center Utrecht, The Netherlands)
Epac and Rap1 in the control of cell adhesion and cell junction formation |
| Yoshimi Takai (Osaka University, Japan)
Signaling by nectins and nectin-like molecules in cell adhesion, migration and proliferation |
| Martin Schwartz (University of Virginia, U.S.A.)
Integrin signaling and Rho GTPases |
| Tony Hyman (Max Planck Institute for Molecular Cell Biology and Genetics, Germany)
Oganization of the cytoskeleton in C.elegans embryos |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell Polarity and migration - II |
| Discussion leader: Greg Gundersen |
| Greg Gundersen (Columbia University, U.S.A.)
Rho GTPases, Microtubules and Cell Polarity |
| Fred Chang (Columbia University College of Physicians and Surgeons, U.S.A.)
Regulating the site of actin assembly by microtubule plus end factors |
| 10:00 am - 10:30 am | Coffee Break |
| Tetsu Akiyama (University of Tokyo, Japan)
Functions of the tumor suppressor APC and Asef |
| Atsuko Kodama (Rockefeller University, U.S.A.)
ACF7: a coordinator of cytoskeletal tracks in directed cell migration |
| Didier Job (Commissariat a l'Energie Atomique, de Grenoble, France)
Pleiotropic functions of the tubulin tyrosination cycle:from cancer progression to brain development |
| Short Talk: Norikazu Yamana (Kyoto University, Japan)
mDia1 regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session / Refreshments |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Axon guidance and synaptic plasticity |
| Discussion leader: Linda van Aelst |
| Yukiko Goda (University College London, England)
Modulating actin dynamics and plasticity at the synapse |
| Mu-Ming Poo (University of California Berkeley, U.S.A.)
Calcium signaling in axon guidance and neuronal migration |
| Linda van Aelst (Cold Spring Harbor Laboratory, U.S.A.)
Role of Rho regulators in neurological disorders |
| Short Talk: Kazuhiro Aoki (Res. Inst. Microbial Diseases, Osaka Univ.)
Local PIP3 Accumulation Recruits Vav2 and Vav3 to Activate Rac1/Cdc42 and Initiate Neurite Outgrowth in Nerve Growth Factor-Stimulated PC12 cells |
| Short Talk: Chuntao Zhao (Institute of Neuroscience, CAS)
Role of PKC-delta in radial migration of rat neocortex |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell proliferation and malignant transformation - I |
| Discussion leader: Dafna Bar-Sagi |
| Dafna Bar-Sagi (State University of New York, U.S.A.)
Ras signaling in cancer initiation and progression |
| Richard Marais (The Institute of Cancer Research, England)
Mechanisms of B-RAF mediated oncogenesis |
| 10:00 am - 10:30 am | Coffee Break |
| David Tuveson (University of Pennsylvania, U.S.A.)
Oncogenic K-Ras induces pancreatic cancer |
| Fuyuhiko Tamanoi (University of California, Los Angeles)
The Rheb GTPase and the control of growth, cell cycle and actin cytoskeleton |
| Valerie Weaver (University of Pennsylvania, U.S.A.)
Tensional homeostasis, integrins and malignant transformation |
| Short Talk: Eric Chang (Baylor College of Medicine)
Regulation of Ras signaling selectivity by Ras GEFs and compartmentalization |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session / Refreshments |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cell proliferation and malignant transformation - II |
| Discussion leader: Chris Marshall |
| Chris Marshall (Cancer Research UK, England)
Interplay between small GTPases in malignant transformation |
| Yukihiko Kabuyama (University of Colorado, U.S.A.)
Identification of Rho GTPase signaling targets by functional proteomics |
| John Blenis (Harvard Medical School, U.S.A.)
Coordination of Ras, PI-3-kinase and nutrient signaling pathways in normal and transformed cells |
| Jonathan Chernoff (Fox Chase Cancer Center, U.S.A.)
A search for allosteric Pak inhibitors |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mitosis and cytokinesis |
| Discussion leader: Shuh Narumiya |
| Ed Manser (Institute of Molecular and Cell Biology, Singapore)
PAK during the cell cycle |
| Bruno Goud (Institut Curie, France)
Role of Rab GTPases in mitosis and cytokinesis |
| 10:00 am - 10:30 am | Coffee Break |
| Robert Rottapel (University of Toronto, Canada)
The Rho GEF Lfc Regulates Spindle Assembly in Early Mitosis |
| Short Talk: Shingo Yasuda (Kyoto University, Japan)
Rho GTPases and mDia isoforms in cell division |
| Short Talk: Hongquan Zhang (Karolinska institutet. Sweden)
Integrins are Potential Cargoes of Unconventional Myosin-X |
| Short Talk: Michelle Knaus (Swiss Federal Institute of Technology Zurich, Switzerland)
The Bud14p-Glc7p protein complex regulates microtubule-cortex interactions in yeast |
| Short Talk: Antje Gohla (Heinrich-Heine-Universitaet Duesseldorf, Germany)
Chronophin, a novel had-type serine protein phosphatase, regulates cofilin-dependent actin dynamics |
| Short Talk: Yi Wang (Baylor College of Medicine)
A mitotic function of the Bloom syndrome protein |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm | Business Meeting |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GTPases in the immune system |
| Discussion leader: Victor L.J. Tybulewicz |
| Nagahiro Minato (Kyoto University, Japan)
Roles of Rap1 GTPase in the functional homeostasis of immune and hematopoietic systems as revealed by the gene-engineered mice |
| Victor L.J. Tybulewicz (National Institute for Medical Research, U.K.)
Role of Rac GTPases and thier exchange factors in lymphocyte development and activation |
| Short Talk: Stephen Smith (Ludwig Institute for Cancer Research)
Characterising the role of PAK1 in bone marrow derived macrophage function |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
