SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | KEYNOTE ADDRESS |
| Martin Schwartz (University of Virginia) "Integrins and small GTPases: a two-way street" |
MONDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | SUBCELLULAR LOCALIZATION OF SMALL GTPASES |
| Discussion Leader: Adrienne Cox (University of North Carolina) |
9:00 am - 9:25 am | Adrienne Cox (University of North Carolina) "A new Rho tail (tale): a story with an unconventional end" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Mark Philips (New York University) "Compartmentalized Ras Signaling: Where is Ras when you really need it?" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break / Group Photo |
10:40 am - 11:05 am | Michiyuki Matsuda (Kyoto U.) "GTPase sensors" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Klaus Hahn (University of North Carolina) "New directions in biosensors" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Yoel Kloog (Tel Aviv University) "Dynamics of Ras mobilization and signaling" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Melissa Greeve (Ontario Cancer Institute) "Dynein light chain, Tctex-1, regulates actin stress fiber assembly by targeting the guanine nucleotide exchange factor, Lfc" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 1 / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | THE BIG PICTURE: INTEGRATING SIGNALING PATHWAYS |
| Discussion Leader: Doug Lauffenberger (Massachusetts Institute of Technology) |
7:30 pm - 7:55 pm | Doug Lauffenberger (Massachusetts Institute of Technology) "Quantitative Integration of Multiple Signaling Pathways for Governance of Cell Behavioral Responses" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Peter Nollau (University Medical Center Hamburg-Eppendorf) "Global characterization of tyrosine phosphorylation by SH2-domains" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Jason Haugh (North Carolina State University) "Quantitative analysis and modeling of signal transduction networks" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Julian Downward (Cancer Research UK, London Research Institute) "Investigation of Ras oncogene signaling networks using functional genomics" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | GTPASES AND THE REGULATION OF CELL DIVISION |
| Discussion Leader: Alan Hall (Memorial Sloan-Kettering Cancer Center) |
9:00 am - 9:25 am | Alan Hall (Memorial Sloan-Kettering Cancer Center) "Rho GTPase signal transduction pathways involved in morphogenesis and migration" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Shuh Narumiya (Kyoto University School of Medicine) "mDia-catalyzed actin-microtubule interaction in interphase and dividing cells" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Tatsuo Kinashi (Kansai Medical University) "The Rap1-RAPL-Mst1 cascade" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Ian Macara (University of Virginia) "An unexpected signaling connection between Septins and NCK" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Channing Der (University of North Carolina) "Aberrant Ras and Rho signaling and oncogenesis" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 2 / Refreshments |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CELL POLARITY AND DIFFERENTIATION |
| Discussion Leader: Valerie Weaver (University of California San Francisco) |
7:30 pm - 7:55 pm | Valerie Weaver (University of California San Francisco) "Forcing form in the third dimension" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Kodi Ravichandran (University of Virginia) "Signaling to engulfment of apoptotic cells: the beginnings of a good meal" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Cayetano Gonzalez (Institut de Recerca Biomedica, Barcelona) "The role of centrosomes in establishing stem cell polarity" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Deborah Yablonski (Technion, Israel Institute of Technology) "Unraveling the role of Pak kinases in T cell migration and polarity" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | CELL ADHESION AND MIGRATION |
| Discussion Leader: Chris Marshall (The Institute for Cancer Research UK) |
9:00 am - 9:25 am | Chris Marshall (The Institute for Cancer Research UK) "TBA" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Hans Bos (UMC Utrecht) "The Rap1 signaling network: Spatial and temporal control of cell adhesion and cell-cell junction formation" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | John Sondek (University of North Carolina) "Connecting Gbeta5/RGS9 to GPCRs" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | John Collard (Nederlands Kanker Instituut) "Tiam1-Rac signaling in cell migration and cell polarity" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Peter Hordijk (University of Amsterdam) "Mechanisms of localized Rac1 signaling in cell migration" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Eric Sahai (Cancer Research UK) "Collective invasion of carcinoma cells is led by fibroblasts: distinct roles for integrins and Rho GTPases in leading and following cells" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session 3 / Refreshments |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | ORGANISMAL BIOLOGY AND DEVELOPMENT |
| Discussion Leader: Jeffrey Settleman (Harvard) |
7:30 pm - 7:55 pm | Georg Halder (MD Anderson) "New tumor suppressor signal transduction pathways in Drosophila" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Linda van Aelst (Cold Spring Harbor Laboratories) "Role of Rho regulators in neuronal development" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Andre Bernards (Massachusetts General Hospital Cancer Center) "Neurofibromatosis-1: Genetic modifiers and beyond" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Jean-Francois Cote (Institut de Recherches Cliniques de Montréal) "The atypical Rac activator Dock180 regulates myoblast fusion in mice" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | SMALL GTPASES, SIGNALING, AND CANCER |
| Discussion Leader: Dafna Bar Sagi (New York University School of Medicine) |
9:00 am - 9:25 am | Dafna Bar Sagi (New York University School of Medicine) "Ras Signaling: The Devil Is In The Details" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | David Tuveson (Cambridge Research Institute, U.K.) "Oncogenic Kras models and medicine" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Ed Manser (Centre for Molecular Medicine, Singapore) "Regulating the localization of Cdc42 effectors" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Frank Slack (Yale University) "Regulation of Ras by miRNA" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Sunil Hingorani (Fred Hutchinson Cancer Research Center) "TBA" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Eric O’Neill (University of Oxford) "RASSF1A elicits apoptosis via the p73 tumour suppressor protein" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:30 pm | Free Time |
5:30 pm | Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | GTPASES AND SIGNALLING-BASED THERAPEUTICS |
| Discussion Leader: Jay Gibbons (Wyeth Pharmaceuticals) |
7:30 pm - 7:55 pm | Jay Gibbons (Wyeth Pharmaceuticals) "Rapalogs and the RheB-mTOR signaling axis" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Lisa Henske (Fox Chase Cancer Center) "Role of the Rheb/B-Raf/mTOR pathway in TSC tumorigenesis" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Yi Zheng (University of Cincinnati School of Medicine) "Inhibitors of small GTPases" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Jeffrey Peterson (Fox Chase Cancer Center) "Exploiting autoregulatory mechanisms to achieve kinase inhibitor specificity: a ‘PAKed’ talk" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am | Departure |