SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
5:30 pm | Welcome Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 8:45 pm | KEYNOTE ADDRESS: CELL SIGNALLING NETWORKS |
| Discussion Leader: Chris Marshall (Institute of Cancer Research, London) |
7:40 pm - 8:30 pm | Douglas Lauffenburger (Massachusetts Institute of Technology, Cambridge) "Integrative Systems Analysis of Cell Signaling Networks: from Relationships to Logic to Mechanism" |
8:30 pm - 8:45 pm | Discussion |
MONDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | ACTIVATION OF SMALL GTPASES |
| Discussion Leader: Erik Sahai (Cancer Research UK London Research Institute) |
9:00 am - 9:25 am | Michiyuki Matsuda (Kyoto University) "Roles of a scaffold protein Shoc2/Sur8 in the regulation of Ras-Raf signaling" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | John Sondek (University of North Carolina at Chapel Hill) "Unconventional RhoGEFs: smgGDS and Dock/Elmo" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break / Group Photo |
10:40 am - 11:05 am | Georgio Scita (IFOM Foundation, Institute FIRC of Molecular Oncology, Milan) "Spatial-restriction of signaling in the control of migratory protrusions and motility programs" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Keith Burridge (University of North Carolina School of Medicine) "RhoGDI and the regulation of Rho protein activity" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Short Talk: Matthias Buck (Case Western Reserve University. Ohio) "Mechanistic insights from the interaction of the cytoplasmic region of the plexin B1 transmembrane receptor with Ras and Rho GTPases" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Short Talk: Heidi Welch (Babraham Institute Cambridge, UK) "New functional roles and mechansims of regulation for P-Rex" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CELL POLARITY |
| Discussion Leader: Martin Schwartz (University of Virginia, Charlottesville) |
7:30 pm - 7:55 pm | Alan Hall (Memorial Sloan-Kettering Cancer Center, New York) "Rho GTPases and epithelial morphogenesis" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Shuh Narymiya (Kyoto University Faculty of Medicine) "Functions of the Rho-mDia pathway in the body; lessons from knockout mice" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Ian Macara (University of Virginia School of Medicine, Charlottesville) "Signaling through polarity proteins in mammary gland morphogenesis" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Kozo Kaibuchi (Nagoya University Graduate School of Medicine) "Roles of Rho family GTPases and Par proteins in directional migration" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | SIGNALLING AT THE NETWORK LEVEL |
| Discussion Leader: Douglas Lauffenburger (Massachusetts Institute of Technology, Cambridge) |
9:00 am - 9:25 am | Forest White (Massachusetts Institute of Technology, Cambridge) "Biological insights from quantitative analysis of tyrosine kinase signaling networks" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Matthias Mann (Max-Planck Institute for Biochemistry, Martinsried) "High resolution phosphoproteomics and proteomics measurements of signal induced changes" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:55 am | Rune Linding (The Institute of Cancer Research, London) "Molecular Logic Gates and Network Medicine" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | John Hancock (University of Texas Health Science Center at Houston) "Ras signaling: space, time and orientation" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Short Talk: Ernest Fraenkel (MIT) "Discovering Signaling Networks by Integrating Proteomic and Transcriptional Data" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:05 pm | Short Talk: Ed Manser (IMCB, Singapore) "Serine/threonine kinase signaling and the global identification of 14-3-3 binding sites" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Short Talk: Erica Golemis (Fox Chase Cancer Centre) "Synthetic lethal screen of an EGFR-centered signaling network defines clusters of proteins contributing to drug resistance" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SENSING THE PHYSICAL ENVIRONMENT |
| Discussion Leader: Linda van Aelst (Cold Spring Harbor Laboratory) |
7:30 pm - 7:55 pm | Alexander Bershadsky (Weizmann Institute of Science, Rehovot) "Force generation and sensing in the interplay between adhesion receptors and the cytoskeleton" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Michael Eck (Dana-Farber Cancer Institute, Harvard Medical School) "Understanding and overcoming drug resistance conferred by the T790M ‘gatekeeper’ mutation in the EGFR kinase" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Martin Schwartz (University of Virginia, Charlottesville) "Integrin regulation of lipid raft trafficking" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Short Talk: Julia Sero (Harvard Medical School) "Spatial Control of Lamellipodia Formation is Regulated by Paxillin" |
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | UBIQUITIN NETWORKS |
| Discussion Leader: Dafna Bar-Sagi (NYU School of Medicine) |
9:00 am - 9:25 am | Ivan Dikic (Goethe University School of Medicine, Frankfurt) "Targeting Ubiquitin networks" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Ron Hay (Wellcome Trust Centre for Gene Regulation and Expression, Dundee) "Arsenic-induced degradation of the Promyelocytic Leukaemia protein" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Stefano Piccolo (University of Padua) "TGFβ signaling in development and cancer" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Matthias Peter (Institute for Biochemistry, ETH Zurich) "Regulation of MAPK signaling by RING-H2 E3 ubiquitin ligases" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Short Talk: Arun Seth (University of Toronto) "BCA2: A Novel RING E3 Ligase Associated With Breast Cancer" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Short Talk: Peter Hordijk (University of Amsterdam, NL) "Caveolin-1 regulates degradation of the small GTPase Rac1" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | SIGNALLING AND CANCER |
| Discussion Leader: Margaret Frame (Institute of Genetics and Molecular Medicine, Edinburgh) |
7:30 pm - 7:55 pm | Dafna Bar-Sagi (NYU School of Medicine) "Ras signaling in health and disease" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Channing Der (University of North Carolina at Chapel Hill) "Searching for the elusive anti-Ras inhibitors for cancer treatment" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Richard Marais (The Institute of Cancer Research, London) "The biology and therapeutic potential of BRAF signaling in melanoma" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Julian Downward (Cancer Research UK London Research Institute) "Investigation of signaling networks involved in transformation by Ras oncogenes" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am - 12:30 pm | CELL ADHESION AND MIGRATION |
| Discussion Leader: Alan Hall (Memorial Sloan-Kettering Cancer Center, New York) |
9:00 am - 9:25 am | Jonathan Chernoff (Fox Chase Cancer Center, Philadelphia) "Pak1 in sickness and in health" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Michael Sixt (Max-Planck Institute for Biochemistry, Martinsried) "Regulation of cytoskeletal dynamics in chemotactic leukocytes" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:55 am | Erik Sahai (Cancer Research UK London Research Institute) "Cancer cell invasion in complex environments" |
10:55 am - 11:00 am | Discussion |
11:00 am - 11:25 am | Margaret Frame (Institute of Genetics and Molecular Medicine, Edinburgh) "Novel tyrosine kinase signaling responses in cancer cells" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Anne Ridley (King's College London) "Signaling by Rho GTPases in cell migration" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Short Talk: Andrew Campbell (Beatson Institute, Glasgow) "Involvement of the Rac exchange factor P-REX1 in melanoma invasion and metastasis" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Short Talk: Klaus Hoeflich (Genentech) "Pak kinases as therapeutic targets" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm | Reception on the Cloisters Lawn |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | ORGANISMAL BIOLOGY AND DEVELOPMENT |
| Discussion Leader: Richard Marais (The Institute of Cancer Research, London) |
7:30 pm - 7:55 pm | Luis Parada (UT Southwestern Medical Center, Dallas) "Modeling neural tumors in the mouse" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Linda van Aelst (Cold Spring Harbor Laboratory) "Regulators of Rho GTPases in neuronal development and disease" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Benny Shilo (Weizmann Institute of Science, Rehovot) "Apical secretion in epithelial tubes of the Drosophila embryo is directed by the Formin- family protein Diaphanous" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Jean-Francois Côté (Institut de Recherches Cliniques de Montréal) "DOCK180 GEFs in signaling and development" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
8:00 am - 9:00 am | Breakfast |
9:00 am | Departure |