Sunday Night: STRUCTURE/MECHANISM CORRELATIONS (Judy Klinman)
(45 min. talk/15 min. discussion)

7:30 p.m. - Donald Hilvert (Scripps Research Institute)
"Selection strategies for generating and characterizing catalysts"

8:30 p.m. - Jack Kirsch (UC Berkeley)
"Schiffty bases: Subtle distinctions in PLP-dependent enzyme mechanisms"

Monday Morning: METAL IONS IN CATALYSIS (Al Mildvan?)
(35 min. talk/10 min. discussion)

9:00 a.m. - Stephen Ragsdale (Nebraska)
"Organometallic Catalysis by Enzymes: an Ancient Biological Strategy for Making and Breaking Carbon-carbon and Carbon-sulfur Bonds"

9:45 a.m. - William Tolman (Minnesota)
"Dioxygen O-O bond scission and generation in metalloenzymes: Insights from synthetic copper chemistry"

10:30 a.m. - BREAK

11:00 a.m. - Stephen Sligar (Illinois)
"Intrafacial Enzymology: Redox Transfer and Catalysis in the Mesoscale Domain"

11:45 a.m. - Mark Nelson (DuPont)
"Nitrile Hydratases - Novel Iron and Cobalt Enzymes"

Monday Night: COUPLED VECTORIAL PROCESSES (John Blanchard)
(35 min. talk/10 min. discussion)

7:30 p.m. - Peter Dimroth (Institute of Technology at Zurich)
"Coupling of the Chemical and Vectorial Reaction in the Oxaloacetate Decarboxylase Sodium Pump"

8:15 p.m. - Kenneth A. Johnson (Penn State)
"Alternating site mechanism of kinesin ATPase"

9:00 p.m. - Jeff Gelles (Brandeis University)
"Single-molecule kinetics of motor enzymes"

Tuesday Morning: INTERFACIAL CATALYSIS (Mahendra Jain)
(35 min. talk/10 min. discussion)

9:00 a.m. - Stuart McLaughlin (SUNY Stony Brook)
"Signal transduction, phospholipase C and the lateral organization of PIP₂ in membranes"

9:45 a.m. - Michael Glaser (Illinois)
"Regulation of signal transduction cascades by membrane domains"

10:30 a.m. - BREAK

11:00 a.m. - Otto Berg (Uppsala)
"Reduced dimensionality: Kinetic and thermodynamic consequences for enzyme activity"

11:45 a.m. - Robert Verger (Marseille)
"Interfacial activation of lipases: facts and artefacts"

Tuesday Night: ENZYMES IN DISEASE (Ruth Mayer)
(35 min. talk/10 min. discussion)

7:30 p.m. - Joan Valentine (UCLA)
"Copper Reactivity in ALS-causing Mutants of CuZnSOD"

8:15 p.m. - Nancy Thornberry (Merck)
"Caspases: Key mediators in apoptosis and inflammation"

9:00 p.m. - John Schloss (Kansas)
"From Enzymes to Receptors"

Wednesday Morning: NUCLEIC ACID ENZYMOLOGY (Dan Herschlag)
(35 min. talk/10 min. discussion)

9:00 a.m. - Anna Marie Pyle (Columbia)
"Formation of an RNA active-site: the folding and reaction mechanisms of group II intron ribozymes"

9:45 a.m. - Jennifer Doudna (Yale)
"A metal ion core at the heart of a group I ribozyme"

10:30 a.m. - BREAK

11:00 a.m. - Felix Althaus (Univ. Zurich)
"Poly ADP-ribosylation: a DNA damage signal mechanism"

11:45 a.m. - Lorena Beese (Duke)
"DNA replication in a crystal: A snapshot of a polymerase in action"

Wednesday Night: CLINICAL ENZYMOLOGY (Don Hupe)
(35 min. talk/10 min. discussion)

7:30 p.m. - Lawrence Marnett (Vanderbilt)
"Modulation of cyclooxygenase catalysis by nitric oxide and peroxynitrite"

8:15 p.m. - David Percival (Merck-Frosst)
"Selective Inhibitor of Cyclooxygenase-2"

9:00 p.m. - Julio Urbina (Venezuelan Institute for Scientific Research, Caracas)
"Rationally designed sterol biosynthesis inhibitors as chemotherapeutic agents against trypanosomatid parasites"

Thursday Morning: ENZYME MECHANISMS (Ron Kluger)
(35 min. talk/10 min. discussion)

9:00 a.m. - Liz Hedstrom (Brandeis)
"The mechanism of IMP dehydrogenase"

9:45 a.m. - John Richard (SUNY Buffalo)
"Structure-reactivity studies on the mechanism of glycosyl transfer reactions catalyzed by Beta-galactosidase"

10:30 a.m. - BREAK

Poster Talks
(15 min. talk/5 min. discussion)

Thursday Evening: BIOSYNTHETIC PATHWAYS (Rowena Matthews)
(35 min. talk/10 min. discussion or 15 min. talk/5 min. discussion)

7:45 p.m. - Rodney Croteau (Washington State)
"Plant terpene synthases: from menthol to taxol"

8:15 p.m. - David Christianson (U. Pennsylvania)
"Crystal structure of pentalenene synthase, a sesquiterpene cyclase" (15 min)

8:35 p.m. - Dennis Schwartz (Oridigm, Inc.)
"Evolution of biosynthetic pathways"