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Genetic Toxicology
June 22-27, 1997
Colby-Sawyer College
New London, NH
Chair:
Kenneth R. Tindall

Sunday Evening

Replication and DNA Damage

Special Lectures:

  • Tom Kunkel [NIEHS] - "Studies of DNA replication fidelity and mismatch repair"
  • Barry Glickman [University of Victoria] - "The Mystic and Reality of Mutation Research"

Monday Morning

DNA Repair

Session Chair: Leona Samson
  • Leona Samson: "Cellular responses to alkylating agents"
  • Isabel Mellon [University of Kentucky] - "Transcription-coupled repair"
  • John Essigmann [MIT]: "Mechanism based design of novel genotoxins"
Discussion Leader: Martin Marinus [University of Massachusetts]

Monday Evening

Damage-Induced Cell Cycle Effects

Session Chair: Al Fornace [NCI]
  • Al Fornace - "Genotoxic-stress response genes involved in growth arrest, Apoptosis, and DNA repair"
  • Nikki Holbrook [NIA-NIH] - "Acute and Adaptive Responses to Environmental Stress - MAPK signaling pathways, induced gene products, and functional consequences"
Discussion Leader: Bill Kaufmann [UNC]

Tuesday Morning

Transgenic Mutation Models

Session Chair: Nancy Gorelick [Proctor and Gamble, Co.]
  • Nancy Gorelick - "Learnings and affirmations from lacl mutational spectra"
  • Tom Skopek [Merck] - "Construction of transgenic mice carrying a lacl target gene with reduced CpG content"
  • Peter Glazer [Yale] - "Sources of genetic instability in cancer: Analysis using a transgenic reporter assay"
Discussion Leader: John Heddle [York University]

Tuesday Evening

Molecular Mechanisms of Skin Carcinogenesis

Session Chair: Fredika Robertson [The Ohio State University]
  • Fredika Robertson - "Functional significance of reactive intermediates produced during multi-stage carcinogenesis"
  • Ron Cannon [NIEHS] - "Understanding the molecular mechanisms of v-Ha-ras transgene activation in Tg.AC Mice"
Discussion Leader: John Mirsalis [SRI]

Wednesday Morning

Novel Approaches for Assessing DNA Damage

Session Chair: Mike Resnick [NIEHS]
  • Ben Van Houten [UTMB-Galveston] - "QPCR measurements of oxidative DNA damage: mitochondrial damage is more extensive and persists longer than nuclear damage"
  • Monica Justice [ORNL] - "Defining the molecular basis of genetic defects caused by environmental agents in the mouse"
  • Dmitry Gordenin [NIEHS] - "At-Risk motifs in the genome"
Discussion Leader: Richard Sinden [Institute of Biosciences and Technology, Texas A&M University]

Wednesday Evening

Environmental Genomics

Session Chair: Sam Wilson [NIEHS]
  • Harvey Mohrenweiser [LLNL] - "Genetic Variation in Genes of DNA Repair: Potential Cancer Risk Factors"
  • Bill Thilly [MIT] - "Gene scanning technology and strategy for population studies"
  • Steve Sommer [City of Hope National Medical Center] - "The molecular epidemiology of p53 gene mutations in human breast cancer"
Discussion Leader: Tom Cebula [FDA]

Thursday Morning

Molecular Epidemiology

Session Chair: Curt Harris [NCI]
  • Curt Harris: "Tumor suppresor genes: At the cross roads of molecular carcinogenesis and molecular epidemiology"
  • Fred Kadlubar [NCTR]: "Genetic polymorphisms, carcinogen-DNA adducts and human cancer susceptibility"
  • John Groopman [Johns Hopkins University] - "Validation of biomarker measurements for exposure assessment and clinical trial intervention"
Discussion Leader: Gerald Wogan [MIT]

Thursday Evening

Keynote Address

  • Miroslav Radman [Institut Jacques Monod, CNRS, Paris, FRANCE] - "Biological Clocks in Genetic Toxicology"
 
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