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Enzymes, Coenzymes & Metabolic Pathways
July 12-17, 1998
Kimball Union Academy
Meriden, NH
Chairs:
Donald J. Hupe & John S. Blanchard

Vice Chairs:
Dan Herschlag & Charles B. Grissom
Sunday Evening:
Bacterial Lipid and Lipopolysaccharide Biosynthesis
Session Chair: Vern Anderson
  • Chris Raetz (Duke University) - Enzymatic Synthesis of Lipid A
  • Charles Rock (St. Judes Childrens Hospital) - Enzymes and Coenzymes that Regulate Bacterial Fatty Acid Biosynthesis
Monday Morning:
Protein Prenylation
Session Chair: Jeff Scholten
  • Michael Gelb (University of Washington) - A Decade of Protein Prenylation Research: From Structures to Enzymes to Medicinal Impact
  • Pat Casey (Duke University) - Mechanisms of Protein Prenylation
  • Judy Sebolt-Leopold (Parke-Davis) - Farnesyltransferase Targeted Anticancer Drug Design: A Mechanism-Based Approach to Molecular Oncology
  • Dale Poulter (University of Utah) - Mechanistic Studies with Farnesyltransferase
Monday Evening:
The Many Faces of Flavins
Session Chair: Charles Williams, Jr.
  • Susan Miller (University of California-San Francisco) - Mercuric Ion Reductase, New Insights Into Nature's Design
  • David Ballou (University of Michigan) - The Wavin' Flavin of para-Hydroxybenzoate Hydroxylase
  • Leslie Poole (Wake Forest University) - Flavin- and cysteine-based redox chemistry of alkyl hydroperoxide reductases
Tuesday Morning:
Enzymes: Structure, Mechanism & Mutagenesis I
Session Chair: Hazel Holden
  • Frank Raushel (Texas A&M University) - Carbamoyl Phosphate Synthetase: A Tunnel Runs Through It
  • Debra Dunaway-Mariano (University of New Mexico) - Enzymology of the P-C bond: A tale of three enzymes
  • Charles Grubmayer (Temple University) - Nucleotide synthases and the catalysis of phosphoribosyl group transfer
  • Joanne Stubbe (Mass. Inst. Of Technology) - Plastics and Peppers: biodegradable polymers with properties of thermoplastics
Tuesday Evening:
Bacterial and Fungal Antibiotic Synthesis
Session Chair: Dan Santi
  • Heinz Floss (University of Washington) - Biosynthesis of Rifamycin and Other Antibiotics
  • Dave Cane (Brown University) - Erythromycin Biosynthesis: Reading the Program
  • Chaitin Khosla (Stanford University) - Specificity and Tolerance in Multifunctional Polyketide Synthases
Wednesday Morning:
Matrix Metalloproteinases
Session Chair: Qizhuang Ye
  • William Stetler-Stevenson (National Cancer Institute) - Matrix Metalloproteinases and Inhibitors in Cancer Progression: Emerging Roles
  • Judith Bond (UPenn-Hershey) - The Metzincin Meprin
  • Marcia Moss (Glaxo-Wellcome) - New Insights into the Structure-Function of TNFalpha Converting Enzyme
  • Gillian Murphy (Norwich University, UK) - A Molecular Approach to the Analysis of Matrix Metalloproteinase Regulation
Wednesday Evening:
Ubiquitin-Dependent Proteolysis
Session Chair: Laura Moen
  • Cecile Pickart (Johns Hopkins) - Proteolytic signaling by polyubiquitin chains
  • Keith Wilkinson (Emory) - Structure and Function of Deubiquitinating Enzymes
  • Ross Stein (Cubist) - Enzymes of the Ubiquitin-Proteasome Pathway as Targets for Therapeutic Intervention in Human Disease
Thursday Morning:
Enzymes II
Session Chair: Chuck Grissom
  • Smita Patel (Ohio State) - Structure and Mechanism of Bacteriophage T7 DNA Helicase
  • David Merkler (Duquesne University) - Peptidylglycine alpha-Amidating Monooxygenase: A Copper and Zinc-Dependent Enzyme and its Metabolic Role in Amidated Hormone Biosynthesis
  • Christopher Walsh (Harvard Med. School) - Posttranslational Priming to Initiate Polyketide and Nonribosomal Polypeptide Biosynthesis
  • Michael Marletta (University of Michigan) - Catalysis by Nitric Oxide Synthase: Will it ever make sense?
Thursday Evening:
Session I: Rose Symposium
Session Chair: Albert Mildvan
  • Irwin A. Rose (Fox Chase Cancer Center) - Behind the scenes of the Fumarase Reaction
  • David Silverman (Florida) - Proton Transfer in Catalysis by Carbonic Anhydrase
Friday Morning:
Session II: Rose Symposium
Session Chair: J. Klinman
  • Albert Mildvan (Johns Hopkins) - Enzyme Structure & Mechanism
  • Mildred Cohn (Univ. Penn.) - The impact of the Stereochemistry of the Enolase Reaction
  • Avram Hershko (Weitzman) - Ernie Rose and the Discovery of the Ubiquitin System
  • Harvey Fisher (VA-Kansas City) - Approaches to Enzyme Mechanism
  • Judith Klinman (Berkeley) - Isotope Effects: Then and Now
 
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