| Discussion Leader: |
Kathryn Sandberg, Depts. of Medicine & Physiology, Georgetown University Medical, Washington, USA |
| Speakers: |
Lee E. Limbird, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
"Location, location, location!!! The key to prompt and sensitive response through
G protein coupled receptors" |
|
Rory Mitchell, MRC Brain Metabolism Unit, Edinburgh, UK
"Extra signals from G protein-coupled receptors" |
|
Terry B. Rogers, Department of Biochemistry, University of Maryland, School
of Medicine, Baltimore, USA
"Intracellular signaling and the regulation of Ca2+ and excitation-contraction
coupling in cardiac myocytes" |
|
Michel Bouvier, Department of Biochemistry, University de Montréal, Montréal, Canada
"Dimerization in G protein-coupled receptor signaling" |
| Discussants: |
Mohammed Showkat Ali, Department of Pathology, Emory University, Atlanta, GA, USA
"Jak2 Regulates the Activation of STAT1 by the Angiotensin II |
| Nicole Gallo-Payet, Department of Medicine, University of Sherbrooke, Québec, Canada
"Neuronal differentiation and human fetal adrenal glands, two targets of the AT2 receptor during development. Why and how?" |
| Anthony J. Balmforth, Institute for Cardiovascular Research, University of Leeds, Leeds, UK
"Is AT1 receptor internalization a prerequisite for Src-mediated activation of ERK1/2" |
| Discussion Leader: |
Tadashi Inagami, Vanderbilt University School of Medicine, Nashville, TN, USA |
| Speakers: |
Jack A. Bikker, Parke-Davis Neuroscience Research Centre, Ann Arbor, MI, USA
"Occum's nightmare, understanding the binding of ligand to GPCR" |
|
Brian K. Kobilka, Stanford University, Stanford, CA, USA
"Ang II and adrenergic receptors". |
|
Marc G. Caron, Duke University Medical Center, Stanford, CA, USA
"Roles of GRKs and Arrestins in the Signaling and the Regulation of the GPCRs" |
| Discussants: |
Sadashiva S. Karnik, Department of Molecular Cardiology, TheCleveland Foundation, Cleveland, OH, USA
"Angiotensin II independent signaling by AT2 receptor" |
|
Walter G. Thomas, Baker Medical Research Institute, Melbourne, Australia
"A novel mechanism for angiotensin II receptor regulation" |
| Antonio C. Paiva, Universidade de Saõ Paolo, Departmento de Biofisica, Saõ Paolo, Brazil
"Interaction of the AT1 receptor with G proteins" |
| Georges Vauquelin, Department of Molecular and Biochemical Pharmacology, Institute of Molecular Biology and Biotechnology, Free University of Brussels, Belgium
"Distinction between surmountable and insurmountable AT1-receptor antagonists" |
| Terry S. Elton, Department of Chemistry and Biochemistry, Brigham Young University, Utah, USA
"Functional significance of alternatively spliced human angiotensin II type 1 receptor mRNAs" |
| Laszlo Hunyady, Department of Physiology, Semmelweis University of Medicine, Budapest, Hungary
"Internalization of the AT1 receptor" |
| Discussion Leader: | Hiroko Nishimura, Dept. of Physiology, University of Tennessee, Memphis, TN, USA |
| Speakers: | Sean Palecek, Center for Molecular Oncology, University of Chicago, Chicago, IL, USA
"The role of extracellular matrix-integrin-cytoskeleton linkages in regulating cell adhesion and cell migration" |
| Jean E. Schwarzbauer, Deptment of Molecular Biology, Princeton University, Princeton, NJ, USA
"Functions follows form: Cell phenotype is specified by extracellular
matrix structure" |
| Harry A.J. Struijker Boudier, Department of Pharmacology and Cardiovascular Center, University of Maastricht, Maastricht, The Netherlands
"Role of angiotensin in matrix deposition and vascular development". |
| Discussants: | Hiroko Nishimura, Department of Physiology, University of Tennessee, Memphis, TN, USA
"Role of osteopontin in neointima formation". |
| Hans Peter Gerber, Genentech Inc., San Francisco, CA, USA
"Vascular endothelial growth factor and angiogenesis". |
| Discussion Leader: |
Martin Paul, Institut für Toxikologie, Freie Universität, Berlin, Germany |
| Speakers: |
Hermann Bujard, Department of Molecular Biology, Heidelberg, Germany
"Tetracyclin-mediated quantitative and tissue-specific control of gene
expression in transgenic animals" |
| Curt Sigmund, University of Iowa College of Medicine, Iowa City, USA
"Tissue specific gene targeting for studying the RAS" |
| Kazuo Murakami, Institute of Applied Biochemistry, University of Tsukuba, Japan
"Blood-brain barrier function in angiotensinogen deficient mice" |
| Lutz Hein, Institut für Pharmakologie und Toxikologie, Universität Würzburg, Germany
"Evaluation of cardiovascular phenotypes in angiotensin receptor knock-out mice" |
| Discussants: | Mat Daemen, Department of Pathology, Universiteit Maastricht, Maastricht, The Netherlands
"Myocardial infarction in AT2 transgenic mice" |
| Mona Nemer, Clinical Research Institute of Montreal, Montreal, Canada
"Cardiovascular phenotype of AT1 receptor transgenic mice" |
| Yigal Pinto, Department of Clinical Pharmacology, Groningen, The Netherlands
"Cardiac effects of overexpression of renin, ACE or AT1 receptors in transgenic rats" |
| Discussion Leader: |
Colin Sumners, Dept. of Physiology, Univ. of Florida, Gainesville, FL, USA |
| Speakers: |
Catherine Llorens-Cortes, Collège de France, Paris, France
"Brain angiotensin peptides and receptors: Neuroanatomical and functional aspects" |
|
Meredith Hay, Dalton CV Research Center, University of Missouri, Columbia, MO, USA
"Angiotensin II reflex function and circulating estrogens" |
|
Craig H. Gelband, Department of Physiology, University of Florida, Gainesville, FL, USA
"Neuronal AT1 receptor signaling pathways: from receptor to channel" |
|
Alistair Ferguson, Queen´s University, Ontario, Canada
"Angiotensin and central autonomic pathways" |
| Discussants: |
Juraj Culman, Institute of Pharmacology, University of Kiel, Kiel, Germany
"Effect of AT1 receptor antagonists on inducible transcription factors and outcome of stroke in the rat" |
| Doris Albrecht, Institut für Physiologie, Humboldt Universität zu Berlin, Germany
"Effects of angiotensin II on discharge rate of amygdaloid neurons" |
| Discussion Leader: |
Kenneth M. Baker, Weis Center for Research, Danville, PA, USA |
| Speakers: | Richard Pratt, Brigham and Women's Hospital, Harvard University, Boston, MA, USA
"Renin-angiotensin system and control of cardiovascular growth" |
|
MAQ Siddiqui, Suny Health Science Center at Brooklyn, State University of New York at Brooklyn, NY, USA
"Regulation of the Angiotensinogen gene by the STAT pathway". |
|
Piero Anversa, New York Medical College, New York, NY, USA
"Myocyte renin-angiotensin system and apoptosis" |
|
Jürg Nussberger, University of Lausanne Medical School, Lausanne, Switzerland
"Biventricular hypertrophy and targeted overexpression of Angiotensinogen in the heart" |
| Discussants: |
Hiroaki Matsubara, Kansai Medical School, University of Osaka, Osaka, Japan
"Differential regulation of AT1 and AT2 receptors" |
|
Dave Dostal, Penn State University, Danville, PA, USA
"Intracardiac RAS regulation" |
|
Timothy L. Reudelhuber, Laboratory of Molecular Biochemistry of Hypertension, IRCM, Montréal, Canada
"Transgenic strategies for the intracardiac renin-angiotensin system" |
| Discussion Leader: |
Alessandro M. Capponi, Division of Endocrinology and Diabetology, University Hospital, Geneva, Switzerland |
| Speakers: |
Peter Hornsby, Baylor College of Medicine, Houston, TX, USA
"Adrenal cell transplantation" |
|
Gavin Vinson, St. Bartholomew´s and Royal London School of Medicine,
London, UK
"The renin-angiotensin-system and adrenocortical zonation" |
|
Janice Douglas, Case Western Reserve University, Cleveland, OH, USA
"Epithelial angiotensin receptors of the kidney" |
| Discussants: |
Daine Alcorn, University of Melbourne, Melbourne, Australia
"Angiotensin in kidney development" |
| Tamas Balla, National Institutes of Health, Bethesda, MD, USA
"Inositol phospholipid dynamics imaged at the single cell level" |
|
Michel Rossier, University Hospital, Geneva, Switzerland
"The coupling between angiotensin receptors and voltage-gated channels in adrenal cells" |
|
William Rainey, University of Texas SW Medical Center, Dallas, TX, USA
"Control of adrenal steroidogenic enzyme expression by angiotensin II" |
| Discussion Leader: |
Bradford Berk, Cardiovascular Research Center, University of Rochester, Rochester, NY, USA |
| Speakers: |
Margaret M. Tarpey, University of Alabama at Birmingham, AL, USA
"Oxidants and vascular disease: in search of the holy grail" |
|
Kathy Griendling, Emory University, Atlanta, GA, USA
"Reactive oxygen species and angiotensin II signaling events" |
| Stephanie Dimmeler, University of Frankfurt, Frankfurt, Germany
"Reactive oxygen species and vascular apoptosis" |
|
Pasal Goldschmidt, Ohio State University, Columbia, OH, USA
"Reactive oxygen species as second messengers" |
| Discussion Leader: |
Bernward Schölkens, Hoechst Marion Russel, Frankfurt, Germany |
| Speakers: |
Philippe Crine, Départment de Biochimie, Université de Montréal, Montréal, Canada
"Neprilysin: New lessons from an old enzyme" |
|
Nick C. Trippodo, Bristol-Myers Squibb Pharmaceutical Research Institute,
Princeton, NJ, USA
"Vasopeptidase inhibition and novel treatment of cardiovascular diseases" |
|
Nancy Brown, Vanderbilt University Medical Center, Nashville, TN, USA
"The role of ACE in the regulation of fibrinolysis." |
| Discussants: |
Folker Franke, Department of Pathology, Universität Giessen, Giessen, Germany
"ACE distribution in health and diseases" |
|
Wolfgang Linz, Hoechst Marion Roussel, Frankfurt, Germany
"Long-term ACE inhibition and ANG AT1 receptor blockade increases lifespan of hypertensive rats - Unifying hypothesis" |
| Tetsuji Miura, Second Department of Internal Medicine, Sapporo Medical College, Sapporo, Japan
"Contribution of NEP 24.11 to bradykinin metabolism during ischemic preconditioning" |