| Sunday, July 11 |
| 4:00 - 6:00 |
Opening Reception |
| Sunday Evening |
Enzyme Mechanisms |
| Phil Cole, Chair |
| 7:30 - 7:45 |
Introductory Remarks |
| 7:45 - 8:35 |
Charles Craik (UCSF)
Combinatorial Methods for Defining the Role of Proteolytic Enzymes Involved in Complex Biological Processes |
| 8:35 - 9:25 |
Nicole Sampson (SUNY Stony Brook)
Enzyme Loops and Lids: The Interplay Between Structure and Catalysis in Cholesterol Oxidase |
| Monday, July 12 |
| Monday Morning |
Enzyme Inhibition and Disease Processes I |
| Ben Liu, Chair |
| 8:45 |
Conference Photograph |
| 9:00 - 9:50 |
Ned Porter (Vanderbilt U.)
Enzyme Photoactivation: Fishing for Proteases |
| 9:50 - 10:40 |
Rebecca Cowling (Wyeth-Ayerst)
Mechanistic Studies of TNF-α Converting Enzyme |
| 10:40 -11:00 |
Coffee Break |
| 11:00 -11:50 |
Pradip Rathod (Catholic U.)
Pyrimidine Synthesis and Inhibition in Malaria |
| 11:50 -12:40 |
Meg Phillips (UT Southwestern)
Ornithine Decarboxylase: Structure, Mechanism, and Drug Design |
| Monday Evening |
Metabolic Pathways in the Post-genome Era |
| J. Gerlt, Chair |
| 7:30 - 8:20 |
Jasper Rine (UC Berkeley)
Gene Expression Profiling at the Interface Between Chemistry and Biology |
| 8:20 - 9:10 |
Pat Brown (Stanford U.)
Whole Genome Approaches to Metabolism |
| 9:10 - 10:00 |
David Pompliano (DuPont Pharm.)
Mining the Mur Pathway for Novel Antibiotics |
| Tuesday, July 13 |
| Tuesday Morning |
Enzyme Inhibition and Disease Processes II |
| John Kozarich, Chair |
| 8:45 - 9:35 |
John Blanchard (Einstein U.)
The Structure and Chemical Mechanism of DAP (Diaminopimelate) E pimerase |
| 9:35 - 10:25 |
Ted Liou (U. of Utah)
You Can't Stop an Angry Neutrophil (Elastase) |
| 10:25 - 10:50 |
Coffee Break |
| 10:50 - 11:40 |
Blaine Knight (Glaxo-Wellcome)
Protein Kinases: Mechanism, Regulation, and Therapeutic Potential |
| 11:40 - 12:05 |
Poster Abstract Talk #1 |
| 12:05 - 12:30 |
Poster Abstract Talk #2 |
| Tuesday Evening |
Metals and Mechanism |
| Ruma Banerjee, Chair |
| 7:30 - 8:20 |
John Caradonna (Boston U.)
Phenylalanine Hydroxylase and the Role of the Cofactor in Understanding the Chemical Basis of PKU |
| 8:20 - 9:10 |
Wayne Frasch (Arizona State U.)
The Participation of Metals in F1 ATPase |
| 9:10 - 10:00 |
George Reed (U. Wisconsin)
Abstractions on Abstractions: Adenyosylcobalamin and Ethanolamine-ammonia Lyase" |
| Wednesday, July 14 |
| Wednesday Morning |
Nucleic Acid Enzymology |
| Peter Beal, Chair |
| 8:45 - 9:35 |
Carol Fierke (U. Michigan)
RNAse P: The Role of the Protein |
| 9:35 - 10:25 |
Tom Ellenberger (Harvard U.)
Structure and Mechanism of DNA Base Excision Glycosylases |
| 10:25 - 10:50 |
Coffee Break |
| 10:50 - 11:40 |
Janet Lindsey (U. Utah)
DNA Topoisomerase II: A Presteady-State Kinetic Analysis |
| 11:40 - 12:30 |
Paul Schimmel (Scripps)
RNA-Dependent Amino Acid Discrimination in Translational Editing |
| Wednesday Evening |
Mechanisms of Complex Systems |
| Chris Whitman, Chair |
| 7:30 - 8:20 |
Tim Lohman (Washington U.)
Helicase-Catalyzed DNA Unwinding |
| 8:20 - 9:10 |
Stephen Kowalczykowski (UC Davis)
Enzymology of genetic recombination: Helicase & DNA Strand Exchange
Mechanisms |
| 9:10 - 10:00 |
Arthur Horwich (Yale U.)
GroEL and GroES |
| Thursday, July 15 |
| Thursday Morning |
Enzyme Mechanisms and Techniques |
| Liz Hedstrom, Chair |
| 8:45 - 9:35 |
Norm Dovichi (Alberta)
Single Molecule Enzymology |
| 9:35 - 10:25 |
Karen Anderson (Yale U.)
Mechanistic Studies of PEP-Utilizing Enzymes |
| 10:25 - 10:50 |
Coffee Break |
| 10:50 - 11:40 |
Marilyn Jorns (Hahnemann U.)
Structure/Function Studies on Sarcosine Oxidase: A Bacterial Hybrid of Two Mammalian Enzymes |
| 11:40 - 12:05 |
Poster Abstract Talk #1 |
| 12:05 - 12:30 |
Poster Abstract Talk #2 |
| Thursday Evening |
Frontiers of Enzymology |
| Jack Kirsch, Chair |
| 8:00 - 9:00 |
Vern Schramm (Einstein U.)
Stereochemical Imperatives for Enzymatic Transition States. |
| 9:00 - 10:00 |
Greg Petsko (Brandeis U.)
Whither Enzymology or Wither Enzymology |