|
| 4:00-6:00 | Opening Reception |
Sunday Evening
(Greg Petsko, Chair) | Enzymes, Coenzymes, and Metabolic Pathways |
|
| 7:30 - 7:45 | Introductory Remarks |
| 7:45 - 8:35 | Judith Klinman (UC Berkeley)
Quinoproteins: How Does a Single Enzyme Make its Own Cofactor |
| 8:35 - 9:25 | Craig Townsend (Johns Hopkins)
Evolution of Enzyme Function and Cofactor Usage in b-Lactam Antibiotic Biosynthesis |
Monday Morning
(Patsy Babbitt, Chair) | Evolution of Enzymes |
|
| 8:45 | Conference Photograph |
| 9:00 - 9:50 | John Gerlt (Illinois)
Catalytic Promiscuity and Diversity in the Enolase Superfamily |
| 9:50 - 10:40 | Richard Armstrong (Vanderbilt)
Mechanism and Evolution of a Metalloenzyme Superfamily |
| 10:40 - 11:00 | Coffee Break |
| 11:00 - 11:50 | JoAnne Stubbe (MIT)
Evolution of a Biosynthetic Pathway: The Purine Pathway as a Paradigm |
| 11:50 - 12:40 | Shelley Copley (Colorado)
Maleylacetoacetate Isomerase to Tetrachlorohydroquinone Dehalogenase: Evolution in Action |
Monday Evening
(Chuck Grissom, Chair) | Techniques in Enzymology |
|
| 7:30 - 8:20 | Ann McDermott (Columbia)
Solid State NMR Studies of Enzymatic Function |
| 8:20 - 9:10 | Dagmar Ringe (Brandeis)
Structure Based Analysis of
the Regulation of a Pathogen Stress Response |
| 9:10 - 10:00 | Peter Schultz (Scripps)
The Generation of Molecular Function: A Lesson from Nature |
Tuesday Morning
(Olivier Ploux, Chair) | Biosynthesis of Coenzymes |
|
| 8:45 - 9:35 | Andree Marquet (University of Paris VI)
Biotin Synthase Mechanism: A New Role or an Iron-Sulfur Cluster? |
| 9:35 - 10:25 | Tadhg Begley (Cornell)
Mechanistic Studies on Thiamine Biosynthetic Enzymes |
| 10:25 - 10:50 | Coffee Break |
| 10:50 - 11:40 | David Cane (Brown)
The Enzymology of Vitamin B6 Biosynthesis |
| 11:40 - 12:30 | Adelbert Bacher (Munich)
Studies on Enzymes Involved in Riboflavin and Pteridine Biosynthesis |
Tuesday Evening
(Peter Tipton, Chair) | Metals in Enzymatic Reactions |
|
| 7:30 - 8:20 | Brian Fox (Wisconsin)
Iron and desaturase: Correlations and Surprise |
| 8:20 - 9:10 | Anne-Frances Miller (Kentucky)
Elucidating the Elements of Redox Catalysis in Superoxide Dismutase |
| 9:10 - 10:00 | Dehua Pei (Ohio State)
Peptide Deformylase: Mechanism and Antibacterial Drug Design |
Wednesday Morning
(Ruma Banerjee, Chair) | Enzyme Mechanisms I |
|
| 8:45 - 9:35 | John Kozarich (Merck)
Pyruvate Formate Lyase |
| 9:35 - 10:25 | Tim Bugg (Warwick)
Catalytic Mechanisms of the Catechol Dioxygenases |
| 10:25 - 10:50 | Coffee Break |
| 10:50 - 11:15 | Eugene Mueller (Delaware)
Getting Sulfur into RNA |
| 11:15 - 11:40 | Ted Holman (UCSC)
Allosteric Inhibition of Soybean and Human 15-Lipoxygenase |
| 11:40 - 12:05 | Suzanne Walker (Princeton)
The structure of E. coli MurG: A Paradigm for NRD1b glycosyltransferases |
| 12:05 - 12:30 | Frank Jordan (Rutgers)
Thiamin Diphosphate-dependent Pyruvate Decarboxylase Active Centers from Yeast and the E. coli Multienzyme Complex |
Wednesday Evening
(Kevin Dalby, Chair) | Enzyme Mechanisms II |
|
| 7:30 - 8:20 | Martin Tanner (Univ of British Columbia) Enzymatic Eliminations Involving Non-Acidic Protons |
| 8:20 - 9:10 | Karen Allen (Boston Univ)
Conserved Chemistry and Active Site Plasticity in the HAD Superfamily |
| 9:10 - 10:00 | Michael Toney (UC Davis) Control of Reaction Specificity in Pyridoxal Phosphate Enzymes |
Thursday Morning
(Don Hupe, Chair) | Enzymes in Action |
|
| 8:45 - 9:35 | Dave Matthews (Agouron)
Structure-assisted Design of Mechanism-based Irreversible Inhibitors of Human Rhinovirus 3C Protease with Potent Antiviral Activity Against Multiple Rhinovirus Serotype |
| 9:35 - 10:25 | Robert A. Copeland (Dupont)
Orotate dehydrogenase |
| 10:25 - 10:50 | Coffee Break |
| 10:50 - 11:40 | Bernard Badet (ICSN, France) Glucosamine-6P from Fructose-6P and Glutamine: the Heyns reaction revisited by Glucosamine-6P Synthase |
| 11:40 - 12:30 | Shahriar Mobashery (Wayne State)
Cross-linking of the Bacterial Cell Wall by Penicillin-binding Proteins, and How this Activity has Given Rise to Antibiotic Resistant Determinants |
Thursday Evening
(Karen Anderson, Chair) |
|
| 8:00 - 9:00 | Dan Herschlag (Stanford)
Energetics of Enzymatic Catalysis: The Limits to
Site-directed Mutagenesis |
| 9:00 - 10:00 | Perry Frey (Wisconsin)
Radicals in Enzymology |