Gordon Research Conferences
Meeting Details

Marine Natural Products
Gordon Research Conference


February 27 - March 3, 2000


Ventura Beach Marriott
Ventura, CA


Valerie J. Paul

Vice Chair:
Alison Butler

Meeting Description

While the central theme of this conference is marine natural products, the conference has evolved in the past decade to be an interdisciplinary forum for discussion of a broad range of issues and aspects of marine natural products. For the 2000 conference, these topics will include: marine toxins, peptides, chemical ecology, biosynthesis, the roles of symbionts in the production of bioactive natural products, marine microorganisms, lead drug discovery and development, synthesis of combinatorial libraries based on marine natural products, new techniques for isolation and structure elucidation, and collection, aquaculture, and conservation of marine invertebrates.

Meeting Program

SUNDAY, February 27 Afternoon
2:00-6:00 pm Registration and Check-In
6:00-7:00 pm Dinner
7:00-9:00 pm Registration and Check-In
SUNDAY, February 27 Evening Session 7:30-9:30 pm
7:30-7:40 Welcome and Conference Policies
Valerie Paul
Marine Toxins and Cytotoxic Natural Products
Discussion Leaders: Alison Butler and Chris Ireland
7:40-8:20 "Challenges to the minuteness of marine toxins"
Takeshi Yasumoto
8:20-8:30 Discussion
8:30-8:50 "Unsuspected biological activities of marine pyridoacridines"
Louis Barrows
8:50-9:00 Discussion
9:00-9:20 "Recent developments in using molecular approaches to discover sponge-derived anticancer leads"
Phil Crews
9:20-9:30 Discussion
9:30-11:30 Chair's Welcoming Reception
MONDAY, February 28 Morning Session 9:00 am-12:30 pm
Marine Toxins
Discussion Leaders: John Cardellina and Tawnya McKee
9:00-9:45 "Generating molecular diversity in Conus peptides: evolutionary, physiological and pharmacological strategies"
Baldomero Olivera
9:45-9:55 Discussion
9:55-10:15 "NMR and molecular modeling studies on the psi?conotoxins: non?competitive antagonists of the nicotinic acetylcholine receptor"
Ryan Van Wagoner
10:15-10:20 Discussion
10:20-10:40 "Topics on tetrodotoxin, saxitoxin, and their binding proteins"
Mari Yotsu-Yamashita
10:40-10:45 Discussion
10:45-11:00 Coffee
11:00-11:20 Photograph
Natural Products from Marine Microorganisms
Discussion Leader: Fritz Schmitz
11:20-12:00 "Bioactive metabolites from marine-derived microorganisms: the utility of LC/MS and LC/MSn"
Leonard McDonald
12:00-12:05 Discussion
12:05-12:25 "Scytonemin- marine natural product inhibitor of inflammation and cell proliferation"
Christopher Stevenson
12:25-12:30 Discussion
12:30 Lunch
1:30 Free Time
Monday Afternoon
4:30-6:00 pm Poster Session #1
6:00 pm Dinner
Monday Evening Session 7:30-9:30 pm
Marine Chemical Ecology
Discussion Leaders: Dale Nagle and Julia Kubanek
7:30-8:15 "Chemical mediation of biological interactions at surfaces"
Peter Steinberg
8:15-8:30 Discussion
8:30-8:50 "Why are marine sponges immune to cytotoxins which they accommodate?"
Kazuo Tachibana
8:50-9:00 Discussion
9:00-9:20 "Metal binding selectivity and possible ecological roles of Lissoclinum patella metabolites"
Marcel Jaspars
9:20-9:30 Discussion
9:30-11:00 Poster Session #1 continued
TUESDAY, February 29 Morning Session 9:00 am-12:30 pm
Synthesis of Combinatorial Libraries of Marine Natural Products
Discussion Leader: Dick Moore
9:00-9:40 "Solid-phase total synthesis of complex natural products: setting the stage for combinatorial synthesis of analogs"
Paul Grothaus
9:40-9:50 Discussion
9:50-10:30 "Synthesis and biological evaluation of a targeted library of curacin A analogs"
Peter Wipf
10:30-10:40 Discussion
10:40-11:00 Coffee
Marine Natural Products: Biological Activities and Applications
Discussion Leader: Fred Valeriote
11:00-11:30 "Exploiting new bioassays to discover anticancer drug leads in marine natural product extract libraries"
Raymond Andersen
11:30-11:40 Discussion
11:40-12:00 "Targeting natural product cytotoxins to tumor vasculature"
Helene Vervoort
12:00-12:05 Discussion
12:05-12:25 "Development of the Pseudopterosins, a commercial skin care additive from the Caribbean gorgonian Pseudopterogorgia elisabethae"
William Fenical
12:25-12:30 Discussion
12:30 Lunch
1:30 Free Time
Tuesday Afternoon
4:30-6:00 pm Poster Session #2
6:00 pm Dinner
Tuesday Evening Session 7:30-9:30 pm
Collection, Conservation, and Aquaculture of Marine Invertebrates
Discussion Leaders: Linda Kupfer and David Newman
7:30-7:50 "Population biology of Pseudopterogorgia elisabethae: ecology of a sustainable (?) coral reef resource"
Howard Lasker
7:50-8:00 Discussion
8:00-8:20 "Sustainable methods for collection and aquaculture of marine invertebrates for natural product production"
Dominick Mendola
8:20-8:30 Discussion
8:30-8:50 "Development of sponge cell culture models for in vitro production"
Shirley Pomponi
8:50-9:00 Discussion
9:00-9:20 "From bioprospecting to new marine reserves- marine natural products researchers and conservationists, an invaluable, obvious, and soon to be commonplace alliance"
Chris Battershill
9:20-9:30 Discussion
9:30-11:00 Poster Session #2 continued
WEDNESDAY, March 1 Morning Session 9:00 am-12:30 pm
Discussion Leaders: William Gerwick and Michelle Prinsep
9:00-9:45 "Combinatorial biosynthetic potential from marine microorganisms"
David Sherman
9:45-9:55 Discussion
9:55-10:15 "Biosynthesis of cyclic peptides and depsipeptides from Nostoc spp. GSV224 and ATCC53789"
Dietmar Hoffmann
10:15-10:20 Discussion
10:20-10:40 "Biosynthesis of brevetoxin revisited: confirmation of previous results and new thinking"
Yuzuru Shimizu
10:40-10:45 Discussion
10:45-11:10 Coffee
Discussion Leader: Roy Okuda
11:10-11:40 "Chemical signals from micro- and macroalgae: biosynthesis and ecology"
Wilhelm Boland and Georg Pohnert
11:40-11:50 Discussion
11:50-12:20 "Cyanide and thiocyanate-based biosynthesis in tropical marine sponges"
Mary Garson
12:20-12:30 Discussion
12:30 Lunch
1:30 Free Time
Wednesday Afternoon
4:30-6:00 pm Poster Session #3
6:00 pm Dinner
Wednesday Evening Session 7:30-9:30 pm
Advances in Instrumentation
Discussion Leaders: Steve Bobzin and Carole Bewley
7:30-7:50 "Mining HPLC-MS data from large natural product extract libraries"
Richard Higgs
7:50-8:00 Discussion
8:00-8:20 "SMIDG-NMR: Doing more NMR quickly and with less stuff"
Gary Martin
8:20-8:30 Discussion
8:30-8:50 "Enhanced measurement and utilization of heteronuclear coupling constants in the structure elucidation of marine natural products"
Thomas Williamson
8:50-9:00 Discussion
9:00-9:20 "Constitutional assignment of marine natural products using ADEQUATE and COCON"
Matthias Köck
9:20-9:30 Discussion
9:30-11:00 Poster Session #3 continued
THURSDAY, March 2 Morning Session 9:00 am-12:30 pm
Discussion Leader: Amy Wright
9:00-9:45 "Bacterial symbionts and marine invertebrate natural products"
Margo Haygood
9:45-9:55 Discussion
9:55-10:15 "Accessing microbial diversity from marine invertebrates: prospects for drug discovery"
Brad Moore
10:15-10:25 Discussion
10:25-10:45 Coffee
Marine Natural Products and their Biological Activities
Discussion Leaders: Yoel Kashman and Tatsuo Higa
10:45-11:05 "New calyculin derivatives: the structure-activity relationships for calyculins"
Toshiyuki Wakimoto
11:05-11:10 Discussion
11:10-11:30 "Recent findings on the mechanism(s) of action of discodermolide"
Ross Longley
11:30-11:35 Discussion
11:35-11:55 "Cell-permeant marine natural products that modulate ion-channels: an electrostatic model for IP3-sensitive Ca2+ channel blockade"
Tadeusz Molinski
11:55-12:00 Discussion
12:00-12:20 "The latest- and perhaps last- kulolides"
Paul Scheuer
12:20-12:30 Discussion
12:30 Lunch
1:30 Free Time
Thursday Afternoon
4:30-6:00 pm Poster Session #4
6:00 pm Dinner
Thursday Evening Session 7:30-9:40 pm
7:30-8:30 Business Meeting
Valerie Paul and Alison Butler
Paul J. Scheuer Award Presentation and Lecture
8:30-8:40 Introductory Remarks
Paul J. Scheuer
8:40-8:45 Award Presentation
Robin Kinnel
Discussion Leader: Robin Kinnel
8:45-9:30 Paul J. Scheuer Award Lecture: "Location, location, location"
D. John Faulkner
9:30-9:40 Discussion
9:40-?? Paul J. Scheuer Award Reception
9:40-11:00 Poster Session #4 continued
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