Gordon Research Conferences
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Conference Program
 
Angiotensin
March 11-16, 2001
Ventura Beach Marriott
Ventura, CA

Sunday Afternoon: Arrival and Registration

Sunday, March 11
Session 1:
Proteomics/Genomics and the renin angiotensin system
Discussion leader: Victor Dzau, Harvard Medical School, Brigham and Women's Hospital, Boston, MA USA
  • C.C. Liew, Brigham and Women's Hospital
    "Overview - From EST to Quantitative Genomics: Current Perspectives in Cardiovascular Medicine"
  • Richard Lawn, CV Therapeutics, Palo Alto, CA USA
    "Discovery of cardiovascular targets using microarray technology: Macrophoge & HDL pathways"
  • Bruce Conklin, Gladstone Institute, San Francisco, CA USA
    "Genomic responses to signaling of engineered receptors and G protein in vivo"
  • Richard Pratt, Brigham and Women's Hospital, Boston, MA
    "Signaling and physiological effect of AT2 receptor"
  • Panel discussion on Techniques and Bioinformatics
Monday, March 12
Session 2:
AT1R signal transduction: Intracellular pathways
Discussion leader: R. Wayne Alexander, Emory University School of Medicine, Atlanta, GA USA
"Overview"
  • Jojo Haendeler, Germany
    "Git-1: A molecular switch that control angiotensin II signal transduction"
  • Peter Sayeski, University of Florida, Gainesville, FL
    "JAK STAT in AngII Signaling"
  • Tadeshi Inagami, University of Vanderbilt, Nashville, TN
    "SHP-2 in AngII signaling"
  • Pam Lucchesi, University of Alabama at Birmingham, Birmingham, AL
    "PYKing your way from the AT1 receptor to vascular smooth muscle cell growth"
Monday, March 12
Session 3:
AT1R signal transduction: Oxidative stress
Discussion leader: Kathy Griendling, Emory University, Atlanta, GA USA
"Introduction/Update"
  • Darren Richard, Centre de Recherche, CHUQA, Quebec, Canada,
    "Vasoactive hormones and hypoxia in the control of vascular endothelial growth factor"
  • Masuko Ushio-Fukai, Emory University, Atlanta, GA
    "Mechanisms of angiotensin II-induced angiogenesis: role of oxidant stress"
  • Christopher Wilcox, Georgetown University Medical Center, Washington, DC
    "Angiotensin II-induced oxidative stress and nephron hypoxia in hypertensive kidney"
  • Ernesto Schiffrin, Institut de recherches cliniques de Montreal, Quebec CANADA
    "Superoxide generation in resistance vessels from normotensive and hypertensive patients"
Monday, March 12
Session 4:
Vascular remodeling and the renin angiotensin system
Discussion leader: Ernesto Schiffrin, Institut de recherches cliniques de Montreal, Quebec CANADA
  • Volkhard Lindner, Maine Medical Center Research Institute, South Portland, ME
    "Genetic aspects of vascular remodeling in mice"
  • Andrew Greene, Medical College of Wisconsin, Milwaukee, WI
    "Microvascular angiogenesis - an essential role for the renin-angiotensin system"
  • Joseph deMey, Maastricht, Holland
    "Interactions of angiotensin and cytoskeleton in vascular remodeling"
  • W. Robert Taylor, Emory University, Atlanta, GA
    "Angiotensin II and atherosclerosis, mechanistic insights"
Tuesday, March 13
Session 5:
Type 2 Angiotensin II receptor (AT2R) signal transduction and biology
Discussion leader: Mohan Raizada, University of Florida, Gainesville, FL USA
  • Colin Sumners, University of Florida, Gainesville, FL
    "AT2-AS Gene transfer"
  • Robert Carey, University of Virginia Health Sciences Center, Charlottesville, VA
    "Expression and functional significance of AT2 receptor in the periphery"
  • Helmy Siragy, University of Virginia Health Sciences Center, Charlottesville, VA
    "AT2 receptor and renal function"
  • Sadashiva Karnik, The Cleveland Clinic Foundation, Cleveland, OH
    "Ligand independent signaling from AT2 receptor"
Tuesday, March 13
Session 6:
Lessons regarding the renin angiotensin system from transgenic experiments
Discussion leader: Kenneth Bernstein, Emory University, Atlanta, GA USA
  • Kirk Thomas, Howard Hughes Medical Institute, Salt Lake City, Utah
    "New strategies in genetic targeting: designing knockout mice in the 21st century"
  • Curt Sigmund, University of Iowa, Iowa City, IA
    "Organ specific knockout of the renin-angiotensin system"
  • Tom Coffmann, Duke University Medical Center, Durham, NC
    "The biology of the AT1 receptor explored using knockout mice"
  • Justin Cole, Emory University, Atlanta GA
    "Selective knockout of angiotensin converting enzyme"
Tuesday, March 13
Session 7:
Cardiac renin angiotensin system
Discussion leader: Kenneth M. Baker, Texas A&M University Health Science Center, Temple, TX USA
"Session Overview"
  • Mona Nemer, University of Montreal, IRCM
    "Targeted overexpression of AT1 in mouse heart"
  • Walter Thomas, Baker Medical Research Institute, Melbourne, Australia
    "Adenoviral mediated overexpression of AT1 in rat cardiac myocytes and fibroblasts"
  • Keichi Fukada, Keio University School of Medicine, Tokyo, Japan
    "Role of AT1 JAK/STAT interactions in stretch mediated cardiomyocyte growth"
  • Hiroaki Matsubara, Kansai Medical University, Osaka, Japan
    "Cardiac AT2 function unmasked by cardiomyocyte or SMC targeted overexpression in mice"
Wednesday, March 14
Session 8:
Vascular renin angiotensin system
Discussion leader: Douglas E. Vaughan, Vanderbilt University Medical Center, Nashville, TN USA
"Angiotensin and PAI-1"
  • Alan Daugherty, University of Kentucky, Lexington, KY
    "Angiotensin and Atherosclerosis"
  • Nancy J. Brown, Vanderbilt University School of Medicine, Nashville, TN
    "Bradykinin metabolism and mechanisms of t-PA release"
  • J.L. Mehta, University of Arkansas for Medical Sciences, Little Rock, AR
    "Angiotensin and the LOX receptor"
Wednesday, March 14
Session 9:
Intrarenal angiotensin: generation, regulation and action
Discussion leader: Willa A. Hsueh, Division of Endocrinology, Diabetes and Hypertension, University of California, Los Angeles, CA USA
  • Wayne Border, University of Utah, Salt Lake City, UT
    "TGF-beta: a critical factor in tissue fibrosis"
  • Susanne Nicholas, University of California, LA
    "Angiotensin II, PPAR-gamma and PAI-1 the mesangium in diabetes"
  • Agnes Fogo, Vanderbilt University, Nashville, TN
    "Angiotensin and PAI-1 potential targets for regression of sclerosis"
  • Christine Maric, University of Melbourne, Australia
    "Osmotic regulation of angiotensin receptors in the renal medulla"
Wednesday, March 14
Session 10:
Angiotensin II & aldosterone: adrenal gland and heart
Discussion leader: Alessandro M. Capponi, Division of Endocrinology and Diabetology, University Hospital, Geneva SWITZERLAND
"Angiotensin II modulates StAR protein and HDL-receptor (SR-BI) expression in ardenal cortex and heart"
  • Claude DelCayre, INSERM, Hopital Lariboisiere, Paris France
    "Interactions of cardiac tissular aldosterone and angiotensin II and their role in cardiac remodeling"
  • Kathleen Kayes-Wandover, University of Texas Southwestern Medical Center, Dallas, TX
    "Aldosterone and the human heart"
  • Annette Fiebeler, Franz Volhard Clinic, Berlin, Germany
    "Role of the mineralocorticoid receptor in the mediation of Ang II-induced vascular injury"
Thursday, March 15
Session 11:
The role of sex in the renin angiotensin system
Discussion leader: Kathryn Sandberg, Departments of Medicine & Physiology, Georgetown University Medical Center, Washington, DC, USA
  • Darren Roesch, Georgetown University, Washington, DC
    "Could an ovarian influence rejuvenate a troubled kidney? New thoughts on estrogens and adrenal and renal responsiveness to angiotensin"
  • Steven Fluharty, University of Pennsylvania, Philadelphia, PA
    "Estrogen regulation of the central actions of Ang II"
  • Bridget Brosnihan, Wake Forest
    "Bidirectional actions of estrogen on the renin angiotensin system"
Thursday, March 15
Session 12:
Inhibitors of the RAS and Cardiovascular Disease Progression
Discussion leader: Jay N. Cohn, University of Minnesota, Cardiovascular Division, Minneapolis, MN USA
"Val-HeFT"
  • Suzanne Oparil, University of Alabama, Birmingham, AL
    "Human RAS"
  • Bertram Pitt, University of Michigan Health Sytem, Ann Arbor, MI
    "ELITE I & II"
  • Bjorn Dahlof, Ostra Hospital, University of Goteborg, Goteborg, Sweden
    "LIFE"
  • Peter Sleight, Cardiovascular Medicine Department, John Radcliffe Hospital, Oxford, UK
    "HOPE"
Thursday, March 15
Session 13:
Keynote lecture: renin angiotensin system and genomics
Discussion Leader: Bradford C. Berk, University of Rochester, Rochester, NY USA
  • Pierre Corvol, College de France, Paris, France
    "Vasoactive peptides and angiogenesis"

 
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