Sunday, June 17
Evening | Protein Electostatics |
R. Lancaster, Chair; C. Wraight - A. Mulkidjanian, Discussion Leaders
- R. Lancaster, Introduction to protein electostatics
- L. Krishtalik, Specific features of proteins as the media for charge transfer reactions
- M. Gunner, Structure-based calculation of proton and electron transfer in proteins.
- J. Bolin, Crystal structure of the Rieske ferredoxin from biphenyl dioxygenase and determinants of the redox properties of Rieske Fe-S proteins.
Monday, June 18
Morning | Intraprotein Charge Transfer |
P. L. Dutton, Chair; J. Onuchic - F. Millett, Discussion Leaders
- P. L. Dutton, What matters when in biological electron transfer?
- A. Stuchebrukhov, Electron transport in proteins
- P. Fromme, High resolution structure of photosystem I: rate-distance relations for electron transfer
- F. Armstrong, Applying dynamic electrochemistry to bioenergetics: revelations on electron/proton transfer and catalytic electron transport
- P. Brzezinski, Charge translocation by cytochrome oxidases
Monday, June 18
Evening | Selective ion transfer mechanisms and signal transduction: Structure-function of bacteriorhodopsin, halorhodopsin, and rhodopsin |
R. Glaeser, Chair; J. Herzfeld, Discussion Leader
- R. Glaeser, Light and life: the rhodopsins
- J. Lanyi, Crystallographic structure of bacteriorhodopsin and its changes during the proton transport cycle
- D. Oesterhelt, Structure-function of halorhodopsin
- D. Teller, Stucture-function of a G-protein receptor, rhodopsin
- J. Spudich, Structure of sensory rhodopsin (short talk)
Tuesday, June 19
Morning | Intramembrane charge transfer: comparison of cytochrome bc1, cytochrome oxidase, and bacterial reaction center complexes (dedicated to Jerry Babcock) |
R. Gennis, Chair; P. Rich, S. Ferguson-Miller, Discussion Leaders
- R. Gennis, Principles of intramembrane charge transfer
- C. Hunte, 2.3 Å structure of yeast cytochrome bc1 complex: pathways of charge transfer.
- A. R. Crofts, Proton-coupled charge transfer in the cytochrome bc1 complex
- S. Iwata, Proton and electron transfer in respiratory complexes.
- M. Paddock, Proton transfer in bacterial reaction centers.
- E. Berry, Comparison of bc structures from mitochondria and bacteria (short talk)
Tuesday, June 19
Evening | Biogenesis of electron transport complexes: how to get it all together |
S. Merchant, Chair; F. Daldal, Discussion Leader
- S. Merchant, Assembly of electron transfer complexes
- F. Wollman, Translational regulation of the assembly of photosynthetic proteins
- L. Thoeny-Meyer, Heme-polypeptide interactions during maturation of cytochrome c
- R. Stuart, Assembly of the mitochondrial respiratory chain complexes in yeast
Wednesday, June 20
Morning | ATPase Nanomotor: Design and evolution of the Gear and Drive Train |
M. Amzel, Chair; R. Capaldi, Discussion Leader
- M. Amzel, Overview of structure-function of ATPases
- J. Walker, The rotary mechanism of ATP synthase
- A. Engel, Imaging membrane protein surfaces with the atomic force microscope
- R. Fillingame, Structural organization and subunit interactions in the Fo rotary motor
- S. D. Dunn, Stalk Structure and Function in ATP Synthase
Wednesday, June 20
Evening | Coupling of FoF1-ATPase to Rotation and Catalysis |
R. Cross, Chair; B. Cain, Discussion Leader
- R. Cross, Overview of rotational coupling
- M. Yoshida, Stepped rotation of F1-ATPase
- W. Junge, Mechanics of rotary ATP synthase
- W. Allison, The Molecular Mechanism of ATP Hydrolysis Catalyzed by F1-ATPases
Thursday, June 21
Morning | Stucture-Function of Transporters (dedicated to Matti Saraste) |
T. Krulwich, Chair; Discussion Leader J. Walker
- T. Krulwich, Pathways towards understanding molecular mechanisms of transport
- A. Senior, Interdomain communication in the P-glycoprotein multidrug resistance protein.
- H. R. Kaback, Kamikaze approach to lac permease structure-function
- W. Kuehlbrandt, Projection structure of NhaA, a secondary transporter from E. coli
- R. M. Stroud, Structure of a glycerol-conducting channel and the basis for its selectivity.
Thursday, June 21
Evening | Global Cellular Bioenergetics |
P. Pedersen, Chair
- P. Pedersen, Mitochondrial Events in the Life and Death of Animal Cells.
- C. Mannella, Folding of the inner mitochondrial membrane: Dynamics and bioenergetic implications
- R. Capaldi, Mitochondrial dynamics and cell control.
- V.Skulachev, Programmed death of mitochondria (mitoptosis), apoptosis, and cytochrome c
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