Gordon Research Conferences
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Conference Program
 
Molecular Mechanisms of Microbial Adhesion
(This meeting is currently known as "Microbial Adhesion & Signal Transduction")
July 29 - August 3, 2001
Salve Regina University
Newport, RI

Contributors
We gratefully acknowledge and thank the following for financial support:

AMERICAN CYANAMID COMPANY
AMERSHAM PHARMACIA BIOTECH INC.
ASTRAZENECA
AVENTIS PASTEUR
BIONICHE LIFE SCIENCES, INC.
BRISTOL-MYERS SQUIBB COMPANY
ELI LILLY AND COMPANY
GLAXOSMITHKLINE BIOLOGICALS S.A.
LIST BIOLOGICAL LABORATORIES. INC.
MERCK & COMPANY, INC.

Sunday Evening
SESSION I
TYPE III SECRETION
Discussion Leader: Jorge Galan
  • Guy Cornelis, Universite Catholique de Louvan'Brussels, Belgium
    Interactions between Yersinia enterocolitica and phagocytes
  • Thorsten Nuernberger, Institute of Plant Biochemistry. Halle/Saale. Gemany
    HrpZ from phytopathogenic Pseudomonas syringae species serves dual functions in bacterial virulence and plant resistance
  • Joan Mecsas, Tufts University. Boston. USA
    A role for Yersinia pseudotuberculosis Yops in colonization of the gastrointestinal tract
  • Jorge Galan, Yale University School of Medicine. New Haven, USA
    Salmonella type III effectors in invasion
Monday Morning
SESSION 2
ADHERENCE MECHANISMS IN MICROBES
Discussion Leader: Robert Kolter
  • Bill Goldman, Washington University School of Medicine. St Louis. USA
    Intracellular survival strategies of Histoplasma capsulatum
  • Paula Sundstrom, Ohio State University, Columbus. USA
    Role of transglutaminase-mediated covalent cross-linking between host cells and Candida albicans in oroesophageal candidiasis
  • Caroline Genco, Boston University School of Medicine, Boston, USA
    Role for Porphyromonas gingivalis fimbriae and the lysine-specific cysteine proteivase Gingipain K in the expression of chemokines and cell adhesion molecules in endothelial cells
  • Robert Kolter, Harvard Medical School. Boston, USA
    Biofilm development
Monday Evening
SESSION 3
BIOPHYSICAL AND STRUCTURAL ASPECTS OF ADHERENCE
Discussion Leader: Jack Dixon
  • Natalie Strynadka, University of British Columbia, Vancouver, Canada
    Structural analysis and inhibition of protein secretion apparatus in bacteria
  • Partho Ghosh, University of California. San Diego, USA
    Structural biology of host-pathogen interactions
  • Bart Hazes, University of Alberta, Edmonton, Canada
    The crystal structure of a P. aeroginosa type IV pilin suggests a molecular mechanism for function-retaining immune evasion in the receptor-binding site
  • Jack Dixon, University of Michigan, Ann Arbor, USA
    Structure of type III effectors
Tuesday Morning
SESSION 4
ORGANELLE ASSEMBLY
Discussion Leader: Scott Hultgren
  • Laura Frost, University of Alberta, Edmonton, Canada
    Mating pair formation during bacterial conjugation: establishing the conjugative pore
  • Graham Walker, Massachusetts Institute of Technology. Cambridge, USA
    Getting inside and living there; Rhizobium symbiosis and Brucella pathogenesis
  • Alan Cowman, The Walter and Eliza Hall Institute of Medical Research. Melbourne, Australia
    Renovations, extensions and moving house: strategies of the malaria parasite to survive in the human erythrocyte
  • David Thanassi, SUNY Stony Brook, New York, USA
    Structural and functional analysis of the PapC usher required for P-pilus biogenesis by uropathogenic E. coli
  • Colette Cywes, Brigham and Women's Hospital and Harvard Medical School, Boston. USA
    CD44-mediated cell signalling in translocation of group A streptococci
  • Scott Hultgren, Washington University School of Medicine, St. Louis. USA
    Host-pathogen interactions in the urinary tract: structure and consequences
Tuesday Evening
SESSION 5
TYPE IV EFFECTORS AND INVASION
Discussion Leader: Howard Shuman
  • Nick Talbot, University of Exeter. UK
    Molecular genetics of infection cell development by the rice blast fungus Magnaporthae grisea
  • Antonello Covacci, IRIS-Chiron SpA, Siena, Italy
    Cag-mediated host responses during infection by Helicobacter pylori
  • Samantha Gruenheid, University of British Columbia, Vancouver. Canada
    Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation
  • Howard Shuman, Columbia University. New York, USA
    The lcm/Dot system of Legionella promotes phagocytosis
Wednesday Morning
SESSION 6
TYPE III EFFECTORS
Discussion Leader: Jeff Miller
  • David Holden, Imperial College School of Medicine. London, UK
    Intracellular activities of the Salmonella SPI-2 type III secretion system
  • Jeff Dangl, University of North Carolina, Chapel Hill, USA
    Proteins at the inner plasma membrane regulate a specific plant disease resistance response
  • Cesare Montecucco, Universita de Padova, Italy
    Cellular and molecular mode of action of the vacuolating toxin VacA and of the neutrophil activating protein HP-NAP of Helicobacter pylori
  • Samuel Miller, University of Washington, Seattle, USA
    The S. typhimurium SPI-2 translocated effectors SspH2 and SseI localize to actin condensations by interaction with the actin binding protein filamin
  • Robin Delahay, Imperial College, London, UK
    Functional domains of CesT that mediate homo- and hetero-oligomeric interactions
  • Jeff Miller, University of California, Los Angeles. USA
    Parasite adaptation to dynamic hosts. Bordetella and their phage
Wednesday Evening
SESSION 7
SIGNALING IN HOST CELLS
  • Pascale Cossart, Institut Pasteur, Paris. France
    Invasion of mammalian cells by Listeria monocytogenes: from in vitro data to in vivo models
  • Alan Aderem, Institute for Systems Biology, Seattle, USA
    Army analysis of macrophages
  • John Brumell, University of British Columbia, Vancouver. Canada
    Characterization of Salmonella-induced filaments (Sifs) reveals a delayed interaction between Salmonella-containing vacuoles and late endocytic compartments
  • Mumtaz Virji, University or Bristol, UK
    Cell adhesion events and virulence of Neisseria meningiditis
Thursday Morning
SESSION 8
NEW MODELS AND TECHNIQUES
Discussion Leader: David Relman
  • Paul Schulze-Lefert, Max-Planck-Institut. Koln. Germany
    Signalling in response to cell wall penetration of powdery mildew fungi
  • Fred Ausubel, Harvard Medical School. Boston. USA
    Use of the nematode C. elegans to study gram positive human pathogens
  • Norma Andrews, Yale University School of Medicine, New Haven, USA
    Lysosornes and trypanosomes: from cell invasion to plasma membrane repair
  • Matthew Mulvey, University of Utah, Salt Lake City, USA
    Interplay between uropathogenic E. coli and the bladder mucosa
  • Jean Greenberg, University of Chicago, USA
    Towards a comprehensive identification of type III effectors from Pseudomonas syringae
  • David Relman, Stanford University, Palto Alto, USA
    Genome-wide transcriptional profiles as a tool for understanding host-microbe interactions
Thursday Evening
SESSION 9
ADHERENCE, SIGNALING, AND INFECTION
Discussion Leader: Philippe Sansonetti
  • Philippe Sansonetti, Institut Pasteur, Paris. France
    Shigella and epithelial cells: from Arp to Nod
  • Keynote Address - Dr. Stanley Falkow, Stanford University, Palo Alto, USA
    Reflections on my 50th reunion

 
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